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Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment.
Protoplasma. 2013 Oct; 250(5):1067-78.P

Abstract

Oxidative stress is a critical contributing factor to age-related neurodegenerative disorders. Therefore, the inhibition of oxidative damage, responsible for chronic detrimental neurodegeneration, is an important strategy for neuroprotective therapy. Withania somnifera (WS) extract has been reported to have potent antioxidant and free radical quenching properties in various disease conditions. The present study evaluated the hypothesis that WS extract would reduce oxidative stress-associated neurodegeneration after intracerebroventricular injection of streptozotocin (ICV-STZ) in rats. To test this hypothesis, male Wistar rats were pretreated with WS extract at doses of 100, 200, and 300 mg/kg body weight once daily for 3 weeks. On day 22nd, the rats were infused bilaterally with ICV-STZ injection (3 mg/kg body weight) in normal saline while sham group received only saline. Two weeks after the lesioning, STZ-infused rats showed cognitive impairment in the Morris water maze test. The rats were sacrificed after 3 weeks of the lesioning for the estimation of the contents of lipid peroxidation, reduced glutathione, and activities of glutathione reductase, glutathione peroxidase, and catalase. Pretreatment with WS extract attenuated behavioral, biochemical, and histological alterations significantly in dose-dependent manner in the hippocampus and cerebral cortex of ICV-STZ-infused rats. These results suggest that WS affords a beneficial effect on cognitive deficit by ameliorating oxidative damage induced by streptozotocin in a model of cognitive impairment.

Authors+Show Affiliations

Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23340606

Citation

Ahmed, Md Ejaz, et al. "Attenuation of Oxidative Damage-associated Cognitive Decline By Withania Somnifera in Rat Model of Streptozotocin-induced Cognitive Impairment." Protoplasma, vol. 250, no. 5, 2013, pp. 1067-78.
Ahmed ME, Javed H, Khan MM, et al. Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment. Protoplasma. 2013;250(5):1067-78.
Ahmed, M. E., Javed, H., Khan, M. M., Vaibhav, K., Ahmad, A., Khan, A., Tabassum, R., Islam, F., Safhi, M. M., & Islam, F. (2013). Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment. Protoplasma, 250(5), 1067-78. https://doi.org/10.1007/s00709-013-0482-2
Ahmed ME, et al. Attenuation of Oxidative Damage-associated Cognitive Decline By Withania Somnifera in Rat Model of Streptozotocin-induced Cognitive Impairment. Protoplasma. 2013;250(5):1067-78. PubMed PMID: 23340606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment. AU - Ahmed,Md Ejaz, AU - Javed,Hayate, AU - Khan,Mohd Moshahid, AU - Vaibhav,Kumar, AU - Ahmad,Ajmal, AU - Khan,Andleeb, AU - Tabassum,Rizwana, AU - Islam,Farah, AU - Safhi,Mohammed M, AU - Islam,Fakhrul, Y1 - 2013/01/23/ PY - 2012/07/19/received PY - 2013/01/07/accepted PY - 2013/1/24/entrez PY - 2013/1/24/pubmed PY - 2014/8/26/medline SP - 1067 EP - 78 JF - Protoplasma JO - Protoplasma VL - 250 IS - 5 N2 - Oxidative stress is a critical contributing factor to age-related neurodegenerative disorders. Therefore, the inhibition of oxidative damage, responsible for chronic detrimental neurodegeneration, is an important strategy for neuroprotective therapy. Withania somnifera (WS) extract has been reported to have potent antioxidant and free radical quenching properties in various disease conditions. The present study evaluated the hypothesis that WS extract would reduce oxidative stress-associated neurodegeneration after intracerebroventricular injection of streptozotocin (ICV-STZ) in rats. To test this hypothesis, male Wistar rats were pretreated with WS extract at doses of 100, 200, and 300 mg/kg body weight once daily for 3 weeks. On day 22nd, the rats were infused bilaterally with ICV-STZ injection (3 mg/kg body weight) in normal saline while sham group received only saline. Two weeks after the lesioning, STZ-infused rats showed cognitive impairment in the Morris water maze test. The rats were sacrificed after 3 weeks of the lesioning for the estimation of the contents of lipid peroxidation, reduced glutathione, and activities of glutathione reductase, glutathione peroxidase, and catalase. Pretreatment with WS extract attenuated behavioral, biochemical, and histological alterations significantly in dose-dependent manner in the hippocampus and cerebral cortex of ICV-STZ-infused rats. These results suggest that WS affords a beneficial effect on cognitive deficit by ameliorating oxidative damage induced by streptozotocin in a model of cognitive impairment. SN - 1615-6102 UR - https://www.unboundmedicine.com/medline/citation/23340606/Attenuation_of_oxidative_damage_associated_cognitive_decline_by_Withania_somnifera_in_rat_model_of_streptozotocin_induced_cognitive_impairment_ L2 - https://dx.doi.org/10.1007/s00709-013-0482-2 DB - PRIME DP - Unbound Medicine ER -