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Serial impedance plethysmography in pregnant patients with clinically suspected deep-vein thrombosis. Clinical validity of negative findings.
Ann Intern Med. 1990 May 01; 112(9):663-7.AIM

Abstract

STUDY OBJECTIVE

To determine the safety of withholding anticoagulant therapy in pregnant patients with clinically suspected deep-vein thrombosis who have negative results by serial impedance plethysmography.

DESIGN

Prospective study evaluating prognosis by long-term follow-up to 3 months postpartum in all patients.

SETTING

University-affiliated community hospital and referral center.

PATIENTS

One hundred fifty-two consecutive pregnant patients referred with clinically suspected deep-vein thrombosis. All patients completed the study.

INTERVENTIONS

Anticoagulant therapy was withheld in 139 patients negative by serial impedance plethysmography, and the patients were followed long term.

MEASUREMENTS AND MAIN RESULTS

None of 139 patients (0%; 95% CI, 0% to 2.6%) had symptomatic pulmonary embolism or recurrent venous thrombosis.

CONCLUSIONS

The findings establish the safety of withholding anticoagulant therapy in pregnant patients who have negative results after serial impedance plethysmography. Sufficient patients were entered to provide narrow confidence intervals on the outcomes observed in patients with negative findings by impedance plethysmography. These findings are similar to those seen after venography in symptomatic patients. These data extend the role of non-invasive testing in patients with clinically suspected deep-vein thrombosis to the pregnant symptomatic patient.

Authors+Show Affiliations

Chedoke-McMaster Hospitals, Hamilton, Ontario, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2334080

Citation

Hull, R D., et al. "Serial Impedance Plethysmography in Pregnant Patients With Clinically Suspected Deep-vein Thrombosis. Clinical Validity of Negative Findings." Annals of Internal Medicine, vol. 112, no. 9, 1990, pp. 663-7.
Hull RD, Raskob GE, Carter CJ. Serial impedance plethysmography in pregnant patients with clinically suspected deep-vein thrombosis. Clinical validity of negative findings. Ann Intern Med. 1990;112(9):663-7.
Hull, R. D., Raskob, G. E., & Carter, C. J. (1990). Serial impedance plethysmography in pregnant patients with clinically suspected deep-vein thrombosis. Clinical validity of negative findings. Annals of Internal Medicine, 112(9), 663-7.
Hull RD, Raskob GE, Carter CJ. Serial Impedance Plethysmography in Pregnant Patients With Clinically Suspected Deep-vein Thrombosis. Clinical Validity of Negative Findings. Ann Intern Med. 1990 May 1;112(9):663-7. PubMed PMID: 2334080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serial impedance plethysmography in pregnant patients with clinically suspected deep-vein thrombosis. Clinical validity of negative findings. AU - Hull,R D, AU - Raskob,G E, AU - Carter,C J, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - 663 EP - 7 JF - Annals of internal medicine JO - Ann Intern Med VL - 112 IS - 9 N2 - STUDY OBJECTIVE: To determine the safety of withholding anticoagulant therapy in pregnant patients with clinically suspected deep-vein thrombosis who have negative results by serial impedance plethysmography. DESIGN: Prospective study evaluating prognosis by long-term follow-up to 3 months postpartum in all patients. SETTING: University-affiliated community hospital and referral center. PATIENTS: One hundred fifty-two consecutive pregnant patients referred with clinically suspected deep-vein thrombosis. All patients completed the study. INTERVENTIONS: Anticoagulant therapy was withheld in 139 patients negative by serial impedance plethysmography, and the patients were followed long term. MEASUREMENTS AND MAIN RESULTS: None of 139 patients (0%; 95% CI, 0% to 2.6%) had symptomatic pulmonary embolism or recurrent venous thrombosis. CONCLUSIONS: The findings establish the safety of withholding anticoagulant therapy in pregnant patients who have negative results after serial impedance plethysmography. Sufficient patients were entered to provide narrow confidence intervals on the outcomes observed in patients with negative findings by impedance plethysmography. These findings are similar to those seen after venography in symptomatic patients. These data extend the role of non-invasive testing in patients with clinically suspected deep-vein thrombosis to the pregnant symptomatic patient. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/2334080/Serial_impedance_plethysmography_in_pregnant_patients_with_clinically_suspected_deep_vein_thrombosis__Clinical_validity_of_negative_findings_ DB - PRIME DP - Unbound Medicine ER -