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Effectiveness of monovalent 2009 pandemic influenza A virus subtype H1N1 and 2010-2011 trivalent inactivated influenza vaccines in Wisconsin during the 2010-2011 influenza season.
J Infect Dis. 2013 Apr 15; 207(8):1262-9.JI

Abstract

BACKGROUND

The 2009 influenza A virus subtype H1N1 (A[H1N1]pdm09) did not exhibit antigenic drift during the 2010-2011 influenza season, providing an opportunity to investigate the duration of protection after vaccination. We estimated the independent effects of 2010-2011 seasonal trivalent inactivated influenza vaccine (TIV) and A(H1N1)pdm09 vaccine for preventing medically attended influenza A virus infection during the 2010-2011 season.

METHODS

Individuals were tested for influenza A virus by real-time reverse transcription polymerase chain reaction (rRT-PCR) after a clinical encounter for acute respiratory illness. Case-control analyses compared participants with rRT-PCR-confirmed influenza A virus infection and test-negative controls. Vaccine effectiveness was estimated separately for monovalent pandemic vaccine and TIV and was calculated as 100 × [1 - adjusted odds ratio], where the odds ratio was adjusted for potential confounders.

RESULTS

The effectiveness of TIV against influenza A virus infection was 63% (95% confidence interval [CI], 37%-78%). The effectiveness of TIV against A(H1N1)pdm09 infection was 77% (95% CI, 44%-90%). Monovalent vaccine administered between October 2009 and April 2010 was not protective during the 2010-2011 season, with an effectiveness of -1% (95% CI, -146% to 59%) against A(H1N1)pdm09 infection.

CONCLUSIONS

Monovalent vaccine provided no sustained protection against A(H1N1)pdm09 infection during the 2010-2011 season. This waning effectiveness supports the need for annual revaccination, even in the absence of antigenic drift in A(H1N1)pdm09.

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Authors+Show Affiliations

Bateman AC
Epidemiology Research Center(ML2), Marshfield Clinic Research Foundation, 1000 N Oak Ave, Marshfield, WI 54449, USA.
Kieke BA
No affiliation info available
Irving SA
No affiliation info available
Meece JK
No affiliation info available
Shay DK
No affiliation info available
Belongia EA
No affiliation info available

MeSH

AdolescentAdultCase-Control StudiesChildFemaleHumansInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesInfluenza, HumanMaleMiddle AgedPandemicsSeasonsWisconsinYoung Adult

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

23341536

Citation

Bateman, Allen C., et al. "Effectiveness of Monovalent 2009 Pandemic Influenza a Virus Subtype H1N1 and 2010-2011 Trivalent Inactivated Influenza Vaccines in Wisconsin During the 2010-2011 Influenza Season." The Journal of Infectious Diseases, vol. 207, no. 8, 2013, pp. 1262-9.
Bateman AC, Kieke BA, Irving SA, et al. Effectiveness of monovalent 2009 pandemic influenza A virus subtype H1N1 and 2010-2011 trivalent inactivated influenza vaccines in Wisconsin during the 2010-2011 influenza season. J Infect Dis. 2013;207(8):1262-9.
Bateman, A. C., Kieke, B. A., Irving, S. A., Meece, J. K., Shay, D. K., & Belongia, E. A. (2013). Effectiveness of monovalent 2009 pandemic influenza A virus subtype H1N1 and 2010-2011 trivalent inactivated influenza vaccines in Wisconsin during the 2010-2011 influenza season. The Journal of Infectious Diseases, 207(8), 1262-9. https://doi.org/10.1093/infdis/jit020
Bateman AC, et al. Effectiveness of Monovalent 2009 Pandemic Influenza a Virus Subtype H1N1 and 2010-2011 Trivalent Inactivated Influenza Vaccines in Wisconsin During the 2010-2011 Influenza Season. J Infect Dis. 2013 Apr 15;207(8):1262-9. PubMed PMID: 23341536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of monovalent 2009 pandemic influenza A virus subtype H1N1 and 2010-2011 trivalent inactivated influenza vaccines in Wisconsin during the 2010-2011 influenza season. AU - Bateman,Allen C, AU - Kieke,Burney A, AU - Irving,Stephanie A, AU - Meece,Jennifer K, AU - Shay,David K, AU - Belongia,Edward A, Y1 - 2013/01/22/ PY - 2013/1/24/entrez PY - 2013/1/24/pubmed PY - 2013/5/7/medline SP - 1262 EP - 9 JF - The Journal of infectious diseases JO - J Infect Dis VL - 207 IS - 8 N2 - BACKGROUND: The 2009 influenza A virus subtype H1N1 (A[H1N1]pdm09) did not exhibit antigenic drift during the 2010-2011 influenza season, providing an opportunity to investigate the duration of protection after vaccination. We estimated the independent effects of 2010-2011 seasonal trivalent inactivated influenza vaccine (TIV) and A(H1N1)pdm09 vaccine for preventing medically attended influenza A virus infection during the 2010-2011 season. METHODS: Individuals were tested for influenza A virus by real-time reverse transcription polymerase chain reaction (rRT-PCR) after a clinical encounter for acute respiratory illness. Case-control analyses compared participants with rRT-PCR-confirmed influenza A virus infection and test-negative controls. Vaccine effectiveness was estimated separately for monovalent pandemic vaccine and TIV and was calculated as 100 × [1 - adjusted odds ratio], where the odds ratio was adjusted for potential confounders. RESULTS: The effectiveness of TIV against influenza A virus infection was 63% (95% confidence interval [CI], 37%-78%). The effectiveness of TIV against A(H1N1)pdm09 infection was 77% (95% CI, 44%-90%). Monovalent vaccine administered between October 2009 and April 2010 was not protective during the 2010-2011 season, with an effectiveness of -1% (95% CI, -146% to 59%) against A(H1N1)pdm09 infection. CONCLUSIONS: Monovalent vaccine provided no sustained protection against A(H1N1)pdm09 infection during the 2010-2011 season. This waning effectiveness supports the need for annual revaccination, even in the absence of antigenic drift in A(H1N1)pdm09. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/23341536/Effectiveness_of_monovalent_2009_pandemic_influenza_A_virus_subtype_H1N1_and_2010_2011_trivalent_inactivated_influenza_vaccines_in_Wisconsin_during_the_2010_2011_influenza_season_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jit020 DB - PRIME DP - Unbound Medicine ER -