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Contact sensitivity to Pityrosporum ovale in patients with atopic dermatitis.
Arch Dermatol. 1990 May; 126(5):627-32.AD

Abstract

Contact sensitivity and immediate hypersensitivity to extracts from Pityrosporum ovale were studied in patients with atopic dermatitis (AD). In a chamber-scarification patch test, 75 (64%) of 118 patients with AD responded positively, compared with 1 (3%) of 35 healthy volunteers. However, no significant statistical correlations were found between contact sensitivity to P ovale in patients with AD and any of the following factors: age, sex, distribution of skin lesions, presence of pruriginous papules, history of infantile seborrheic dermatitis, or concomitance of other atopic diseases. Lymphocyte transformation test with P ovale antigen confirmed that those with positive patch test reactions showed significantly high stimulation indexes. The antigenic substances divided by gel filtration high-performance liquid chromatography were found in a fraction of components with molecular weights above 60 kd. In addition, 25 (71%) of 35 patients with AD showed a positive immediate response to P ovale extract in a prick test, whereas none of 11 healthy volunteers showed any response. Although the incidence of the positive immediate responses was similar to that in contact sensitivity, there was no clear correlation between the delayed and immediate hypersensitivity reactions. Based on these results, we think that P ovale plays a role as an allergen derived from the host environment in the exacerbation of the skin lesions of AD.

Authors+Show Affiliations

Rokugo M
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Tagami H
No affiliation info available
Usuba Y
No affiliation info available
Tomita Y
No affiliation info available

MeSH

AdolescentAdultChildDermatitis, AtopicFemaleHumansHypersensitivity, ImmediateLymphocyte ActivationMalasseziaMaleMiddle AgedPatch Tests

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2334183

Citation

Rokugo, M, et al. "Contact Sensitivity to Pityrosporum Ovale in Patients With Atopic Dermatitis." Archives of Dermatology, vol. 126, no. 5, 1990, pp. 627-32.
Rokugo M, Tagami H, Usuba Y, et al. Contact sensitivity to Pityrosporum ovale in patients with atopic dermatitis. Arch Dermatol. 1990;126(5):627-32.
Rokugo, M., Tagami, H., Usuba, Y., & Tomita, Y. (1990). Contact sensitivity to Pityrosporum ovale in patients with atopic dermatitis. Archives of Dermatology, 126(5), 627-32.
Rokugo M, et al. Contact Sensitivity to Pityrosporum Ovale in Patients With Atopic Dermatitis. Arch Dermatol. 1990;126(5):627-32. PubMed PMID: 2334183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contact sensitivity to Pityrosporum ovale in patients with atopic dermatitis. AU - Rokugo,M, AU - Tagami,H, AU - Usuba,Y, AU - Tomita,Y, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - 627 EP - 32 JF - Archives of dermatology JO - Arch Dermatol VL - 126 IS - 5 N2 - Contact sensitivity and immediate hypersensitivity to extracts from Pityrosporum ovale were studied in patients with atopic dermatitis (AD). In a chamber-scarification patch test, 75 (64%) of 118 patients with AD responded positively, compared with 1 (3%) of 35 healthy volunteers. However, no significant statistical correlations were found between contact sensitivity to P ovale in patients with AD and any of the following factors: age, sex, distribution of skin lesions, presence of pruriginous papules, history of infantile seborrheic dermatitis, or concomitance of other atopic diseases. Lymphocyte transformation test with P ovale antigen confirmed that those with positive patch test reactions showed significantly high stimulation indexes. The antigenic substances divided by gel filtration high-performance liquid chromatography were found in a fraction of components with molecular weights above 60 kd. In addition, 25 (71%) of 35 patients with AD showed a positive immediate response to P ovale extract in a prick test, whereas none of 11 healthy volunteers showed any response. Although the incidence of the positive immediate responses was similar to that in contact sensitivity, there was no clear correlation between the delayed and immediate hypersensitivity reactions. Based on these results, we think that P ovale plays a role as an allergen derived from the host environment in the exacerbation of the skin lesions of AD. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/2334183/Contact_sensitivity_to_Pityrosporum_ovale_in_patients_with_atopic_dermatitis_ DB - PRIME DP - Unbound Medicine ER -