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Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats.
J Psychopharmacol 2013; 27(3):312-6JP

Abstract

Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle.

OBJECTIVE

The objective of this paper is to assess the effects on sleep of acute systemic administration of CBD.

METHOD

Adult male Wistar rats were randomly distributed into four groups that received intraperitoneal injections of CBD 2.5 mg/kg, CBD 10 mg/kg, CBD 40 mg/kg or vehicle (n=seven animals/group). Sleep recordings were made during light and dark periods for four days: two days of baseline recording, one day of drug administration (test), and one day after drug (post-test).

RESULTS

During the light period of the test day, the total percentage of sleep significantly increased in the groups treated with 10 and 40 mg/kg of CBD compared to placebo. REM sleep latency increased in the group injected with CBD 40 mg/kg and was significantly decreased with the dose of 10 mg/kg on the post-test day. There was an increase in the time of SWS in the group treated with CBD 40 mg/kg, although this result did not reach statistical significance.

CONCLUSION

The systemic acute administration of CBD appears to increase total sleep time, in addition to increasing sleep latency in the light period of the day of administration.

Authors+Show Affiliations

Department of Neuroscience and Behavior of the Ribeirão Preto Medical School, University of São Paulo, INCT Translational Medicine (CNPq), São Paulo, Brazil. mchagas@fmrp.usp.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23343597

Citation

Chagas, Marcos Hortes N., et al. "Effects of Acute Systemic Administration of Cannabidiol On Sleep-wake Cycle in Rats." Journal of Psychopharmacology (Oxford, England), vol. 27, no. 3, 2013, pp. 312-6.
Chagas MH, Crippa JA, Zuardi AW, et al. Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats. J Psychopharmacol (Oxford). 2013;27(3):312-6.
Chagas, M. H., Crippa, J. A., Zuardi, A. W., Hallak, J. E., Machado-de-Sousa, J. P., Hirotsu, C., ... Andersen, M. L. (2013). Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats. Journal of Psychopharmacology (Oxford, England), 27(3), pp. 312-6. doi:10.1177/0269881112474524.
Chagas MH, et al. Effects of Acute Systemic Administration of Cannabidiol On Sleep-wake Cycle in Rats. J Psychopharmacol (Oxford). 2013;27(3):312-6. PubMed PMID: 23343597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats. AU - Chagas,Marcos Hortes N, AU - Crippa,José Alexandre S, AU - Zuardi,Antonio Waldo, AU - Hallak,Jaime E C, AU - Machado-de-Sousa,João Paulo, AU - Hirotsu,Camila, AU - Maia,Lucas, AU - Tufik,Sergio, AU - Andersen,Monica Levy, Y1 - 2013/01/23/ PY - 2013/1/25/entrez PY - 2013/1/25/pubmed PY - 2013/8/21/medline SP - 312 EP - 6 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 27 IS - 3 N2 - UNLABELLED: Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle. OBJECTIVE: The objective of this paper is to assess the effects on sleep of acute systemic administration of CBD. METHOD: Adult male Wistar rats were randomly distributed into four groups that received intraperitoneal injections of CBD 2.5 mg/kg, CBD 10 mg/kg, CBD 40 mg/kg or vehicle (n=seven animals/group). Sleep recordings were made during light and dark periods for four days: two days of baseline recording, one day of drug administration (test), and one day after drug (post-test). RESULTS: During the light period of the test day, the total percentage of sleep significantly increased in the groups treated with 10 and 40 mg/kg of CBD compared to placebo. REM sleep latency increased in the group injected with CBD 40 mg/kg and was significantly decreased with the dose of 10 mg/kg on the post-test day. There was an increase in the time of SWS in the group treated with CBD 40 mg/kg, although this result did not reach statistical significance. CONCLUSION: The systemic acute administration of CBD appears to increase total sleep time, in addition to increasing sleep latency in the light period of the day of administration. SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/23343597/Effects_of_acute_systemic_administration_of_cannabidiol_on_sleep_wake_cycle_in_rats_ L2 - http://journals.sagepub.com/doi/full/10.1177/0269881112474524?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -