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Effect of subthalamic nucleus or globus pallidus interna stimulation on oculomotor function in patients with Parkinson's disease.
Stereotact Funct Neurosurg. 2013; 91(2):113-21.SF

Abstract

BACKGROUND

Deep brain stimulation (DBS) of either the globus pallidus interna (GPi) or subthalamic nucleus (STN) is similarly effective for treating somatomotor manifestations of Parkinson's disease (PD), but differences in how stimulation of each target affects oculomotor function are poorly understood.

OBJECTIVE

We sought to determine if stimulation of the STN, but not the GPi, affects oculomotor function in PD patients.

METHODS

Nineteen PD patients with DBS implants (8 bilateral GPi, 9 bilateral STN and 2 unilateral STN) were studied. Testing was performed with stimulation on, then off. Somatomotor function was tested using the Unified Parkinson's Disease Rating Scale (UPDRS) motor exam. For oculomotor testing, patients performed pro- and antisaccade tasks while monitored with an infrared eye tracker. Saccadic latency, saccadic intrusions, and square-wave jerks (SWJs) were measured for each trial.

RESULTS

As expected, UPDRS motor scores improved with both GPi and STN stimulation. With GPi stimulation, there was no significant difference in oculomotor function with stimulation on or off. However, with STN stimulation on, there was a significant increase in the mean number of SWJs/s, as well as a significant decrease in latency for both pro- and antisaccade tasks.

CONCLUSION

Stimulation of either GPi or STN had similar effects on somatomotor function, but only STN stimulation significantly altered oculomotor function.

Authors+Show Affiliations

Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23343617

Citation

Fridley, Jared, et al. "Effect of Subthalamic Nucleus or Globus Pallidus Interna Stimulation On Oculomotor Function in Patients With Parkinson's Disease." Stereotactic and Functional Neurosurgery, vol. 91, no. 2, 2013, pp. 113-21.
Fridley J, Adams G, Sun P, et al. Effect of subthalamic nucleus or globus pallidus interna stimulation on oculomotor function in patients with Parkinson's disease. Stereotact Funct Neurosurg. 2013;91(2):113-21.
Fridley, J., Adams, G., Sun, P., York, M., Atassi, F., Lai, E., Simpson, R., Viswanathan, A., & Yoshor, D. (2013). Effect of subthalamic nucleus or globus pallidus interna stimulation on oculomotor function in patients with Parkinson's disease. Stereotactic and Functional Neurosurgery, 91(2), 113-21. https://doi.org/10.1159/000343200
Fridley J, et al. Effect of Subthalamic Nucleus or Globus Pallidus Interna Stimulation On Oculomotor Function in Patients With Parkinson's Disease. Stereotact Funct Neurosurg. 2013;91(2):113-21. PubMed PMID: 23343617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of subthalamic nucleus or globus pallidus interna stimulation on oculomotor function in patients with Parkinson's disease. AU - Fridley,Jared, AU - Adams,Gareth, AU - Sun,Ping, AU - York,Michelle, AU - Atassi,Farah, AU - Lai,Eugene, AU - Simpson,Richard, AU - Viswanathan,Ashwin, AU - Yoshor,Daniel, Y1 - 2013/01/22/ PY - 2012/07/05/received PY - 2012/09/01/accepted PY - 2013/1/25/entrez PY - 2013/1/25/pubmed PY - 2014/1/10/medline SP - 113 EP - 21 JF - Stereotactic and functional neurosurgery JO - Stereotact Funct Neurosurg VL - 91 IS - 2 N2 - BACKGROUND: Deep brain stimulation (DBS) of either the globus pallidus interna (GPi) or subthalamic nucleus (STN) is similarly effective for treating somatomotor manifestations of Parkinson's disease (PD), but differences in how stimulation of each target affects oculomotor function are poorly understood. OBJECTIVE: We sought to determine if stimulation of the STN, but not the GPi, affects oculomotor function in PD patients. METHODS: Nineteen PD patients with DBS implants (8 bilateral GPi, 9 bilateral STN and 2 unilateral STN) were studied. Testing was performed with stimulation on, then off. Somatomotor function was tested using the Unified Parkinson's Disease Rating Scale (UPDRS) motor exam. For oculomotor testing, patients performed pro- and antisaccade tasks while monitored with an infrared eye tracker. Saccadic latency, saccadic intrusions, and square-wave jerks (SWJs) were measured for each trial. RESULTS: As expected, UPDRS motor scores improved with both GPi and STN stimulation. With GPi stimulation, there was no significant difference in oculomotor function with stimulation on or off. However, with STN stimulation on, there was a significant increase in the mean number of SWJs/s, as well as a significant decrease in latency for both pro- and antisaccade tasks. CONCLUSION: Stimulation of either GPi or STN had similar effects on somatomotor function, but only STN stimulation significantly altered oculomotor function. SN - 1423-0372 UR - https://www.unboundmedicine.com/medline/citation/23343617/Effect_of_subthalamic_nucleus_or_globus_pallidus_interna_stimulation_on_oculomotor_function_in_patients_with_Parkinson's_disease_ L2 - https://www.karger.com?DOI=10.1159/000343200 DB - PRIME DP - Unbound Medicine ER -