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Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies.
J Nutr 2013; 143(3):345-53JN

Abstract

Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [β = -0.009 mmol/L (95% CI: -0.013, -0.005), P < 0.0001] and insulin [-0.020 ln-pmol/L (95% CI: -0.024, -0.017), P < 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted.

Authors+Show Affiliations

Tufts University Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23343670

Citation

Hruby, Adela, et al. "Higher Magnesium Intake Is Associated With Lower Fasting Glucose and Insulin, With No Evidence of Interaction With Select Genetic Loci, in a Meta-analysis of 15 CHARGE Consortium Studies." The Journal of Nutrition, vol. 143, no. 3, 2013, pp. 345-53.
Hruby A, Ngwa JS, Renström F, et al. Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. J Nutr. 2013;143(3):345-53.
Hruby, A., Ngwa, J. S., Renström, F., Wojczynski, M. K., Ganna, A., Hallmans, G., ... Nettleton, J. A. (2013). Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. The Journal of Nutrition, 143(3), pp. 345-53. doi:10.3945/jn.112.172049.
Hruby A, et al. Higher Magnesium Intake Is Associated With Lower Fasting Glucose and Insulin, With No Evidence of Interaction With Select Genetic Loci, in a Meta-analysis of 15 CHARGE Consortium Studies. J Nutr. 2013;143(3):345-53. PubMed PMID: 23343670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. AU - Hruby,Adela, AU - Ngwa,Julius S, AU - Renström,Frida, AU - Wojczynski,Mary K, AU - Ganna,Andrea, AU - Hallmans,Göran, AU - Houston,Denise K, AU - Jacques,Paul F, AU - Kanoni,Stavroula, AU - Lehtimäki,Terho, AU - Lemaitre,Rozenn N, AU - Manichaikul,Ani, AU - North,Kari E, AU - Ntalla,Ioanna, AU - Sonestedt,Emily, AU - Tanaka,Toshiko, AU - van Rooij,Frank J A, AU - Bandinelli,Stefania, AU - Djoussé,Luc, AU - Grigoriou,Efi, AU - Johansson,Ingegerd, AU - Lohman,Kurt K, AU - Pankow,James S, AU - Raitakari,Olli T, AU - Riserus,Ulf, AU - Yannakoulia,Mary, AU - Zillikens,M Carola, AU - Hassanali,Neelam, AU - Liu,Yongmei, AU - Mozaffarian,Dariush, AU - Papoutsakis,Constantina, AU - Syvänen,Ann-Christine, AU - Uitterlinden,André G, AU - Viikari,Jorma, AU - Groves,Christopher J, AU - Hofman,Albert, AU - Lind,Lars, AU - McCarthy,Mark I, AU - Mikkilä,Vera, AU - Mukamal,Kenneth, AU - Franco,Oscar H, AU - Borecki,Ingrid B, AU - Cupples,L Adrienne, AU - Dedoussis,George V, AU - Ferrucci,Luigi, AU - Hu,Frank B, AU - Ingelsson,Erik, AU - Kähönen,Mika, AU - Kao,W H Linda, AU - Kritchevsky,Stephen B, AU - Orho-Melander,Marju, AU - Prokopenko,Inga, AU - Rotter,Jerome I, AU - Siscovick,David S, AU - Witteman,Jacqueline C M, AU - Franks,Paul W, AU - Meigs,James B, AU - McKeown,Nicola M, AU - Nettleton,Jennifer A, Y1 - 2013/01/23/ PY - 2013/1/25/entrez PY - 2013/1/25/pubmed PY - 2013/4/10/medline SP - 345 EP - 53 JF - The Journal of nutrition JO - J. Nutr. VL - 143 IS - 3 N2 - Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [β = -0.009 mmol/L (95% CI: -0.013, -0.005), P < 0.0001] and insulin [-0.020 ln-pmol/L (95% CI: -0.024, -0.017), P < 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/23343670/Higher_magnesium_intake_is_associated_with_lower_fasting_glucose_and_insulin_with_no_evidence_of_interaction_with_select_genetic_loci_in_a_meta_analysis_of_15_CHARGE_Consortium_Studies_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.112.172049 DB - PRIME DP - Unbound Medicine ER -