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Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging.
Age (Dordr). 2013 Dec; 35(6):2183-92.A

Abstract

The complex mixture of phytochemicals in fruits and vegetables provides protective health benefits, mainly through additive and/or synergistic effects. The presence of several bioactive compounds, such as polyphenols and caffeine, implicates coffee as a potential nutritional therapeutic in aging. Moderate (three to five cups a day) coffee consumption in humans is associated with a significant decrease in the risk of developing certain chronic diseases. However, the ability of coffee supplementation to improve cognitive function in aged individuals and the effect of the individual components in coffee, such as caffeine, have not been fully evaluated. We fed aged rats (19 months) one of five coffee-supplemented diets (0, 0.165, 0.275, 0.55, and 0.825% of the diet) for 8 weeks prior to motor and cognitive behavior assessment. Aged rats supplemented with a 0.55% coffee diet, equivalent to ten cups of coffee, performed better in psychomotor testing (rotarod) and in a working memory task (Morris water maze) compared to aged rats fed a control diet. A diet with 0.55% coffee appeared to be optimal. The 0.165% coffee-supplemented group (three cups) showed some improvement in reference memory performance in the Morris water maze. In a subsequent study, the effects of caffeine alone did not account for the performance improvements, showing that the neuroprotective benefits of coffee are not due to caffeine alone, but rather to other bioactive compounds in coffee. Therefore, coffee, in achievable amounts, may reduce both motor and cognitive deficits in aging.

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Authors+Show Affiliations

Shukitt-Hale B
United States Department of Agriculture-ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA, barbara.shukitthale@ars.usda.gov.
Miller MG
No affiliation info available
Chu YF
No affiliation info available
Lyle BJ
No affiliation info available
Joseph JA
No affiliation info available

MeSH

AgingAnimalsBehavior, AnimalBeveragesCaffeineCentral Nervous System StimulantsCoffeeCognitionCognition DisordersDisease Models, AnimalMalePsychomotor PerformanceRatsRats, Inbred F344

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23344884

Clinical Trial Links

Whole Coffee Cherry Study

Citation

Shukitt-Hale, Barbara, et al. "Coffee, but Not Caffeine, Has Positive Effects On Cognition and Psychomotor Behavior in Aging." Age (Dordrecht, Netherlands), vol. 35, no. 6, 2013, pp. 2183-92.
Shukitt-Hale B, Miller MG, Chu YF, et al. Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. Age (Dordr). 2013;35(6):2183-92.
Shukitt-Hale, B., Miller, M. G., Chu, Y. F., Lyle, B. J., & Joseph, J. A. (2013). Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. Age (Dordrecht, Netherlands), 35(6), 2183-92. https://doi.org/10.1007/s11357-012-9509-4
Shukitt-Hale B, et al. Coffee, but Not Caffeine, Has Positive Effects On Cognition and Psychomotor Behavior in Aging. Age (Dordr). 2013;35(6):2183-92. PubMed PMID: 23344884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. AU - Shukitt-Hale,Barbara, AU - Miller,Marshall G, AU - Chu,Yi-Fang, AU - Lyle,Barbara J, AU - Joseph,James A, Y1 - 2013/01/24/ PY - 2011/08/19/received PY - 2012/12/28/accepted PY - 2013/1/25/entrez PY - 2013/1/25/pubmed PY - 2014/6/20/medline SP - 2183 EP - 92 JF - Age (Dordrecht, Netherlands) JO - Age (Dordr) VL - 35 IS - 6 N2 - The complex mixture of phytochemicals in fruits and vegetables provides protective health benefits, mainly through additive and/or synergistic effects. The presence of several bioactive compounds, such as polyphenols and caffeine, implicates coffee as a potential nutritional therapeutic in aging. Moderate (three to five cups a day) coffee consumption in humans is associated with a significant decrease in the risk of developing certain chronic diseases. However, the ability of coffee supplementation to improve cognitive function in aged individuals and the effect of the individual components in coffee, such as caffeine, have not been fully evaluated. We fed aged rats (19 months) one of five coffee-supplemented diets (0, 0.165, 0.275, 0.55, and 0.825% of the diet) for 8 weeks prior to motor and cognitive behavior assessment. Aged rats supplemented with a 0.55% coffee diet, equivalent to ten cups of coffee, performed better in psychomotor testing (rotarod) and in a working memory task (Morris water maze) compared to aged rats fed a control diet. A diet with 0.55% coffee appeared to be optimal. The 0.165% coffee-supplemented group (three cups) showed some improvement in reference memory performance in the Morris water maze. In a subsequent study, the effects of caffeine alone did not account for the performance improvements, showing that the neuroprotective benefits of coffee are not due to caffeine alone, but rather to other bioactive compounds in coffee. Therefore, coffee, in achievable amounts, may reduce both motor and cognitive deficits in aging. SN - 1574-4647 UR - https://www.unboundmedicine.com/medline/citation/23344884/Coffee_but_not_caffeine_has_positive_effects_on_cognition_and_psychomotor_behavior_in_aging_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23344884/ DB - PRIME DP - Unbound Medicine ER -