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Effect of coenzyme-q10 on Doxorubicin-induced nephrotoxicity in rats.
Adv Pharmacol Sci. 2012; 2012:981461.AP

Abstract

Nephrotoxicity is one of the limiting factors for using doxorubicin (Dox) as an anticancer chemotherapeutic. Here, we investigated possible protective effect of coenzyme-Q10 (CoQ10) on Dox-induced nephrotoxicity and the mechanisms involved. Two doses (10 and 100 mg/kg) of CoQ10 were administered orally to rats for 8 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of Dox (15 mg/kg) at day 4 of the experiment. Our results showed that the low dose of CoQ10 succeeded in reversing Dox-induced nephrotoxicity to control levels (e.g., levels of blood urea nitrogen and serum creatinine, concentrations of renal reduced glutathione (GSH) and malondialdehyde, catalase activity and caspase 3 expression, and renal histopathology). Alternatively, the high dose of CoQ10 showed no superior nephroprotection over the low dose, as there were no significant improvements in renal histopathology, catalase activity, or caspase 3 expression compared to the Dox-treated group. Interestingly, the high dose of CoQ10 alone significantly decreased renal GSH level as well as catalase activity and caused a mild induction of caspase 3 expression compared to control, probably due to a prooxidant effect at this dose of CoQ10. We conclude that CoQ10 protects from Dox-induced nephrotoxicity with a precaution to dosage adjustment.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine, Minia University, 61511 El-Minia, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23346106

Citation

El-Sheikh, Azza A K., et al. "Effect of Coenzyme-q10 On Doxorubicin-induced Nephrotoxicity in Rats." Advances in Pharmacological Sciences, vol. 2012, 2012, p. 981461.
El-Sheikh AA, Morsy MA, Mahmoud MM, et al. Effect of coenzyme-q10 on Doxorubicin-induced nephrotoxicity in rats. Adv Pharmacol Sci. 2012;2012:981461.
El-Sheikh, A. A., Morsy, M. A., Mahmoud, M. M., Rifaai, R. A., & Abdelrahman, A. M. (2012). Effect of coenzyme-q10 on Doxorubicin-induced nephrotoxicity in rats. Advances in Pharmacological Sciences, 2012, 981461. https://doi.org/10.1155/2012/981461
El-Sheikh AA, et al. Effect of Coenzyme-q10 On Doxorubicin-induced Nephrotoxicity in Rats. Adv Pharmacol Sci. 2012;2012:981461. PubMed PMID: 23346106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of coenzyme-q10 on Doxorubicin-induced nephrotoxicity in rats. AU - El-Sheikh,Azza A K, AU - Morsy,Mohamed A, AU - Mahmoud,Marwa M, AU - Rifaai,Rehab A, AU - Abdelrahman,Aly M, Y1 - 2012/12/17/ PY - 2012/08/12/received PY - 2012/11/09/revised PY - 2012/11/12/accepted PY - 2013/1/25/entrez PY - 2013/1/25/pubmed PY - 2013/1/25/medline SP - 981461 EP - 981461 JF - Advances in pharmacological sciences JO - Adv Pharmacol Sci VL - 2012 N2 - Nephrotoxicity is one of the limiting factors for using doxorubicin (Dox) as an anticancer chemotherapeutic. Here, we investigated possible protective effect of coenzyme-Q10 (CoQ10) on Dox-induced nephrotoxicity and the mechanisms involved. Two doses (10 and 100 mg/kg) of CoQ10 were administered orally to rats for 8 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of Dox (15 mg/kg) at day 4 of the experiment. Our results showed that the low dose of CoQ10 succeeded in reversing Dox-induced nephrotoxicity to control levels (e.g., levels of blood urea nitrogen and serum creatinine, concentrations of renal reduced glutathione (GSH) and malondialdehyde, catalase activity and caspase 3 expression, and renal histopathology). Alternatively, the high dose of CoQ10 showed no superior nephroprotection over the low dose, as there were no significant improvements in renal histopathology, catalase activity, or caspase 3 expression compared to the Dox-treated group. Interestingly, the high dose of CoQ10 alone significantly decreased renal GSH level as well as catalase activity and caused a mild induction of caspase 3 expression compared to control, probably due to a prooxidant effect at this dose of CoQ10. We conclude that CoQ10 protects from Dox-induced nephrotoxicity with a precaution to dosage adjustment. SN - 1687-6342 UR - https://www.unboundmedicine.com/medline/citation/23346106/Effect_of_coenzyme_q10_on_Doxorubicin_induced_nephrotoxicity_in_rats_ L2 - https://doi.org/10.1155/2012/981461 DB - PRIME DP - Unbound Medicine ER -
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