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Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours.
Histopathology. 2013 Mar; 62(4):657-61.H

Abstract

AIMS

To determine the prevalence of MED12 mutations in smooth muscle tumours of different organs.

METHODS AND RESULTS

A total of 142 smooth muscle tumours of the uterus, gastrointestinal tract, retroperitoneum and soft tissue were analysed for MED12 mutations using Sanger sequencing. Among the uterine tumours that were examined, MED12 mutations were identified in 36 of 45 conventional leiomyomas (80%), two of six cellular leiomyomas (33%), one of four bizarre leiomyomas (25%), none of four lipoleiomyomas (0%), and two of 12 leiomyosarcomas (17%). The two MED12-mutated leiomyosarcomas were associated with benign leiomyomatous components that also harboured MED12 mutations identical to those in the respective leiomyosarcomatous components. None of the extrauterine smooth muscle tumours, including the leiomyomas, leiomyosarcomas, and angioleiomyomas, had MED12 mutations.

CONCLUSIONS

Among uterine smooth muscle tumours, MED12 mutations are frequently present in conventional leiomyomas, but are significantly less common in histological variants of leiomyoma and leiomyosarcoma. In contrast to uterine lesions, none of the extrauterine smooth muscle tumours had MED12 mutations.

Authors+Show Affiliations

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23347103

Citation

Matsubara, Akiko, et al. "Prevalence of MED12 Mutations in Uterine and Extrauterine Smooth Muscle Tumours." Histopathology, vol. 62, no. 4, 2013, pp. 657-61.
Matsubara A, Sekine S, Yoshida M, et al. Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours. Histopathology. 2013;62(4):657-61.
Matsubara, A., Sekine, S., Yoshida, M., Yoshida, A., Taniguchi, H., Kushima, R., Tsuda, H., & Kanai, Y. (2013). Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours. Histopathology, 62(4), 657-61. https://doi.org/10.1111/his.12039
Matsubara A, et al. Prevalence of MED12 Mutations in Uterine and Extrauterine Smooth Muscle Tumours. Histopathology. 2013;62(4):657-61. PubMed PMID: 23347103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours. AU - Matsubara,Akiko, AU - Sekine,Shigeki, AU - Yoshida,Masayuki, AU - Yoshida,Akihiko, AU - Taniguchi,Hirokazu, AU - Kushima,Ryoji, AU - Tsuda,Hitoshi, AU - Kanai,Yae, Y1 - 2013/01/24/ PY - 2012/07/31/received PY - 2012/10/03/accepted PY - 2013/1/26/entrez PY - 2013/1/26/pubmed PY - 2013/8/24/medline SP - 657 EP - 61 JF - Histopathology JO - Histopathology VL - 62 IS - 4 N2 - AIMS: To determine the prevalence of MED12 mutations in smooth muscle tumours of different organs. METHODS AND RESULTS: A total of 142 smooth muscle tumours of the uterus, gastrointestinal tract, retroperitoneum and soft tissue were analysed for MED12 mutations using Sanger sequencing. Among the uterine tumours that were examined, MED12 mutations were identified in 36 of 45 conventional leiomyomas (80%), two of six cellular leiomyomas (33%), one of four bizarre leiomyomas (25%), none of four lipoleiomyomas (0%), and two of 12 leiomyosarcomas (17%). The two MED12-mutated leiomyosarcomas were associated with benign leiomyomatous components that also harboured MED12 mutations identical to those in the respective leiomyosarcomatous components. None of the extrauterine smooth muscle tumours, including the leiomyomas, leiomyosarcomas, and angioleiomyomas, had MED12 mutations. CONCLUSIONS: Among uterine smooth muscle tumours, MED12 mutations are frequently present in conventional leiomyomas, but are significantly less common in histological variants of leiomyoma and leiomyosarcoma. In contrast to uterine lesions, none of the extrauterine smooth muscle tumours had MED12 mutations. SN - 1365-2559 UR - https://www.unboundmedicine.com/medline/citation/23347103/Prevalence_of_MED12_mutations_in_uterine_and_extrauterine_smooth_muscle_tumours_ L2 - https://doi.org/10.1111/his.12039 DB - PRIME DP - Unbound Medicine ER -