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Preparation of sustained-release dosage form of Venlafaxine HCl using liquisolid technique.
Pharm Dev Technol. 2014 Feb; 19(1):103-15.PD

Abstract

CONTEXT

The aim of this study is to control the dissolution rate of Venlafaxine HCl.

OBJECTIVE

To prepare sustained release tablets of Venlafaxine HCl.

MATERIAL AND METHODS

Different liquisolid formulations, liquid vehicles, drug concentration in the liquid medication and different ratios of carrier to coating material (R) were prepared. The prepared powders were characterized for possible interactions between drug and excipients using differential scanning calorimetry, X-ray, Fourier transform infrared analysis and scanning electron microscopy. Powder flowability was also evaluated, then they are compressed at different compression forces, and the compressed tablets were evaluated for their mechanical properties and dissolution profile.

RESULTS

Release results show that sustained release behavior can be obtained from liquisolid formulation containing Tween 80 as liquid vehicle.

DISCUSSION

Many factors affect the retardation effect of Venlafaxine HCl such as the type of liquid vehicle, drug concentration in the liquid medication and R. The mechanism of the in vitro release profiles was found to be mainly controlled by diffusion and polymer relaxation.

CONCLUSION

Sustained release formulation of Venlafaxine HCl was attained using the liquisolid technique.

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Publisher Full Text

Authors+Show Affiliations

Khanfar M
Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology , Irbid , Jordan.
Sheikh Salem M
No affiliation info available
Kaddour F
No affiliation info available

MeSH

Antidepressive Agents, Second-GenerationCyclohexanolsDelayed-Action PreparationsExcipientsPolysorbatesPowdersSolubilityVenlafaxine Hydrochloride

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23347382

Citation

Khanfar, M, et al. "Preparation of Sustained-release Dosage Form of Venlafaxine HCl Using Liquisolid Technique." Pharmaceutical Development and Technology, vol. 19, no. 1, 2014, pp. 103-15.
Khanfar M, Sheikh Salem M, Kaddour F. Preparation of sustained-release dosage form of Venlafaxine HCl using liquisolid technique. Pharm Dev Technol. 2014;19(1):103-15.
Khanfar, M., Sheikh Salem, M., & Kaddour, F. (2014). Preparation of sustained-release dosage form of Venlafaxine HCl using liquisolid technique. Pharmaceutical Development and Technology, 19(1), 103-15. https://doi.org/10.3109/10837450.2012.757785
Khanfar M, Sheikh Salem M, Kaddour F. Preparation of Sustained-release Dosage Form of Venlafaxine HCl Using Liquisolid Technique. Pharm Dev Technol. 2014;19(1):103-15. PubMed PMID: 23347382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation of sustained-release dosage form of Venlafaxine HCl using liquisolid technique. AU - Khanfar,M, AU - Sheikh Salem,M, AU - Kaddour,Faiza, Y1 - 2013/01/24/ PY - 2013/1/26/entrez PY - 2013/1/26/pubmed PY - 2014/7/16/medline SP - 103 EP - 15 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 19 IS - 1 N2 - CONTEXT: The aim of this study is to control the dissolution rate of Venlafaxine HCl. OBJECTIVE: To prepare sustained release tablets of Venlafaxine HCl. MATERIAL AND METHODS: Different liquisolid formulations, liquid vehicles, drug concentration in the liquid medication and different ratios of carrier to coating material (R) were prepared. The prepared powders were characterized for possible interactions between drug and excipients using differential scanning calorimetry, X-ray, Fourier transform infrared analysis and scanning electron microscopy. Powder flowability was also evaluated, then they are compressed at different compression forces, and the compressed tablets were evaluated for their mechanical properties and dissolution profile. RESULTS: Release results show that sustained release behavior can be obtained from liquisolid formulation containing Tween 80 as liquid vehicle. DISCUSSION: Many factors affect the retardation effect of Venlafaxine HCl such as the type of liquid vehicle, drug concentration in the liquid medication and R. The mechanism of the in vitro release profiles was found to be mainly controlled by diffusion and polymer relaxation. CONCLUSION: Sustained release formulation of Venlafaxine HCl was attained using the liquisolid technique. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/23347382/Preparation_of_sustained_release_dosage_form_of_Venlafaxine_HCl_using_liquisolid_technique_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2012.757785 DB - PRIME DP - Unbound Medicine ER -