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A case-control study of diet and benign proliferative epithelial disorders of the breast.
Cancer Res. 1990 Jun 01; 50(11):3176-81.CR

Abstract

Benign proliferative epithelial disorders (BPED) of the breast are conditions which, although not proven precursors of breast cancer, are strongly associated with increased risk of this disease. In a case-control study conducted in Adelaide, South Australia, we investigated the association between dietary factors and risk of BPED. The study involved 383 cases of biopsy-confirmed BPED, 192 controls whose biopsy did not show epithelial proliferation, and 383 unbiopsied community controls matched to cases on age and area of residence. When cases were compared with community controls, there was little variation in the risk of BPED across levels of daily intake of energy, protein, and fat, but there was some suggestion of inverse associations with daily intake of retinol, beta-carotene, and fiber; in contrast, with biopsy controls as the comparison group, risk of BPED increased with increasing energy and fat intake but varied little with retinol, beta-carotene, and fiber intake. The results of this study provide additional evidence against roles for dietary energy and fat intake in the etiology of breast cancer. However, further studies of diet and BPED should be conducted in populations surveyed cross-sectionally for breast changes, in an attempt to limit or avoid the selection and misclassification biases to which studies of putative precursor lesions are susceptible.

Authors+Show Affiliations

National Cancer Institute of Canada Epidemiology Unit, University of Toronto, Ontario.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2334913

Citation

Rohan, T E., et al. "A Case-control Study of Diet and Benign Proliferative Epithelial Disorders of the Breast." Cancer Research, vol. 50, no. 11, 1990, pp. 3176-81.
Rohan TE, Cook MG, Potter JD, et al. A case-control study of diet and benign proliferative epithelial disorders of the breast. Cancer Res. 1990;50(11):3176-81.
Rohan, T. E., Cook, M. G., Potter, J. D., & McMichael, A. J. (1990). A case-control study of diet and benign proliferative epithelial disorders of the breast. Cancer Research, 50(11), 3176-81.
Rohan TE, et al. A Case-control Study of Diet and Benign Proliferative Epithelial Disorders of the Breast. Cancer Res. 1990 Jun 1;50(11):3176-81. PubMed PMID: 2334913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case-control study of diet and benign proliferative epithelial disorders of the breast. AU - Rohan,T E, AU - Cook,M G, AU - Potter,J D, AU - McMichael,A J, PY - 1990/6/1/pubmed PY - 1990/6/1/medline PY - 1990/6/1/entrez SP - 3176 EP - 81 JF - Cancer research JO - Cancer Res VL - 50 IS - 11 N2 - Benign proliferative epithelial disorders (BPED) of the breast are conditions which, although not proven precursors of breast cancer, are strongly associated with increased risk of this disease. In a case-control study conducted in Adelaide, South Australia, we investigated the association between dietary factors and risk of BPED. The study involved 383 cases of biopsy-confirmed BPED, 192 controls whose biopsy did not show epithelial proliferation, and 383 unbiopsied community controls matched to cases on age and area of residence. When cases were compared with community controls, there was little variation in the risk of BPED across levels of daily intake of energy, protein, and fat, but there was some suggestion of inverse associations with daily intake of retinol, beta-carotene, and fiber; in contrast, with biopsy controls as the comparison group, risk of BPED increased with increasing energy and fat intake but varied little with retinol, beta-carotene, and fiber intake. The results of this study provide additional evidence against roles for dietary energy and fat intake in the etiology of breast cancer. However, further studies of diet and BPED should be conducted in populations surveyed cross-sectionally for breast changes, in an attempt to limit or avoid the selection and misclassification biases to which studies of putative precursor lesions are susceptible. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/2334913/A_case_control_study_of_diet_and_benign_proliferative_epithelial_disorders_of_the_breast_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=2334913 DB - PRIME DP - Unbound Medicine ER -