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Fruit and vegetable intake and risk of breast cancer by hormone receptor status.
J Natl Cancer Inst. 2013 Feb 06; 105(3):219-36.JNCI

Abstract

BACKGROUND

Estrogen receptor-negative (ER(-)) breast cancer has few known or modifiable risk factors. Because ER(-) tumors account for only 15% to 20% of breast cancers, large pooled analyses are necessary to evaluate precisely the suspected inverse association between fruit and vegetable intake and risk of ER(-) breast cancer.

METHODS

Among 993 466 women followed for 11 to 20 years in 20 cohort studies, we documented 19 869 estrogen receptor positive (ER(+)) and 4821 ER(-) breast cancers. We calculated study-specific multivariable relative risks (RRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression analyses and then combined them using a random-effects model. All statistical tests were two-sided.

RESULTS

Total fruit and vegetable intake was statistically significantly inversely associated with risk of ER(-) breast cancer but not with risk of breast cancer overall or of ER(+) tumors. The inverse association for ER(-) tumors was observed primarily for vegetable consumption. The pooled relative risks comparing the highest vs lowest quintile of total vegetable consumption were 0.82 (95% CI = 0.74 to 0.90) for ER(-) breast cancer and 1.04 (95% CI = 0.97 to 1.11) for ER(+) breast cancer (P (common-effects) by ER status < .001). Total fruit consumption was non-statistically significantly associated with risk of ER(-) breast cancer (pooled multivariable RR comparing the highest vs lowest quintile = 0.94, 95% CI = 0.85 to 1.04).

CONCLUSIONS

We observed no association between total fruit and vegetable intake and risk of overall breast cancer. However, vegetable consumption was inversely associated with risk of ER(-) breast cancer in our large pooled analyses.

Links

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Authors+Show Affiliations

Jung S
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Longwood Avenue, Boston, MA 02115, USA. pojun@channing.harvard.edu
Spiegelman D
No affiliation info available
Baglietto L
No affiliation info available
Bernstein L
No affiliation info available
Boggs DA
No affiliation info available
van den Brandt PA
No affiliation info available
Buring JE
No affiliation info available
Cerhan JR
No affiliation info available
Gaudet MM
No affiliation info available
Giles GG
No affiliation info available
Goodman G
No affiliation info available
Hakansson N
No affiliation info available
Hankinson SE
No affiliation info available
Helzlsouer K
No affiliation info available
Horn-Ross PL
No affiliation info available
Inoue M
No affiliation info available
Krogh V
No affiliation info available
Lof M
No affiliation info available
McCullough ML
No affiliation info available
Miller AB
No affiliation info available
Neuhouser ML
No affiliation info available
Palmer JR
No affiliation info available
Park Y
No affiliation info available
Robien K
No affiliation info available
Rohan TE
No affiliation info available
Scarmo S
No affiliation info available
Schairer C
No affiliation info available
Schouten LJ
No affiliation info available
Shikany JM
No affiliation info available
Sieri S
No affiliation info available
Tsugane S
No affiliation info available
Visvanathan K
No affiliation info available
Weiderpass E
No affiliation info available
Willett WC
No affiliation info available
Wolk A
No affiliation info available
Zeleniuch-Jacquotte A
No affiliation info available
Zhang SM
No affiliation info available
Zhang X
No affiliation info available
Ziegler RG
No affiliation info available
Smith-Warner SA
No affiliation info available

MeSH

AdultAgedBiomarkers, TumorBreast NeoplasmsClinical Trials as TopicFeeding BehaviorFemaleFruitHumansMiddle AgedMultivariate AnalysisProspective StudiesReceptors, EstrogenReceptors, ProgesteroneRiskSurveys and QuestionnairesVegetables

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23349252

Citation

Jung, Seungyoun, et al. "Fruit and Vegetable Intake and Risk of Breast Cancer By Hormone Receptor Status." Journal of the National Cancer Institute, vol. 105, no. 3, 2013, pp. 219-36.
Jung S, Spiegelman D, Baglietto L, et al. Fruit and vegetable intake and risk of breast cancer by hormone receptor status. J Natl Cancer Inst. 2013;105(3):219-36.
Jung, S., Spiegelman, D., Baglietto, L., Bernstein, L., Boggs, D. A., van den Brandt, P. A., Buring, J. E., Cerhan, J. R., Gaudet, M. M., Giles, G. G., Goodman, G., Hakansson, N., Hankinson, S. E., Helzlsouer, K., Horn-Ross, P. L., Inoue, M., Krogh, V., Lof, M., McCullough, M. L., ... Smith-Warner, S. A. (2013). Fruit and vegetable intake and risk of breast cancer by hormone receptor status. Journal of the National Cancer Institute, 105(3), 219-36. https://doi.org/10.1093/jnci/djs635
Jung S, et al. Fruit and Vegetable Intake and Risk of Breast Cancer By Hormone Receptor Status. J Natl Cancer Inst. 2013 Feb 6;105(3):219-36. PubMed PMID: 23349252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit and vegetable intake and risk of breast cancer by hormone receptor status. AU - Jung,Seungyoun, AU - Spiegelman,Donna, AU - Baglietto,Laura, AU - Bernstein,Leslie, AU - Boggs,Deborah A, AU - van den Brandt,Piet A, AU - Buring,Julie E, AU - Cerhan,James R, AU - Gaudet,Mia M, AU - Giles,Graham G, AU - Goodman,Gary, AU - Hakansson,Niclas, AU - Hankinson,Susan E, AU - Helzlsouer,Kathy, AU - Horn-Ross,Pamela L, AU - Inoue,Manami, AU - Krogh,Vittorio, AU - Lof,Marie, AU - McCullough,Marjorie L, AU - Miller,Anthony B, AU - Neuhouser,Marian L, AU - Palmer,Julie R, AU - Park,Yikyung, AU - Robien,Kim, AU - Rohan,Thomas E, AU - Scarmo,Stephanie, AU - Schairer,Catherine, AU - Schouten,Leo J, AU - Shikany,James M, AU - Sieri,Sabina, AU - Tsugane,Schoichiro, AU - Visvanathan,Kala, AU - Weiderpass,Elisabete, AU - Willett,Walter C, AU - Wolk,Alicja, AU - Zeleniuch-Jacquotte,Anne, AU - Zhang,Shumin M, AU - Zhang,Xuehong, AU - Ziegler,Regina G, AU - Smith-Warner,Stephanie A, Y1 - 2013/01/24/ PY - 2013/1/26/entrez PY - 2013/1/26/pubmed PY - 2013/4/2/medline SP - 219 EP - 36 JF - Journal of the National Cancer Institute JO - J Natl Cancer Inst VL - 105 IS - 3 N2 - BACKGROUND: Estrogen receptor-negative (ER(-)) breast cancer has few known or modifiable risk factors. Because ER(-) tumors account for only 15% to 20% of breast cancers, large pooled analyses are necessary to evaluate precisely the suspected inverse association between fruit and vegetable intake and risk of ER(-) breast cancer. METHODS: Among 993 466 women followed for 11 to 20 years in 20 cohort studies, we documented 19 869 estrogen receptor positive (ER(+)) and 4821 ER(-) breast cancers. We calculated study-specific multivariable relative risks (RRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression analyses and then combined them using a random-effects model. All statistical tests were two-sided. RESULTS: Total fruit and vegetable intake was statistically significantly inversely associated with risk of ER(-) breast cancer but not with risk of breast cancer overall or of ER(+) tumors. The inverse association for ER(-) tumors was observed primarily for vegetable consumption. The pooled relative risks comparing the highest vs lowest quintile of total vegetable consumption were 0.82 (95% CI = 0.74 to 0.90) for ER(-) breast cancer and 1.04 (95% CI = 0.97 to 1.11) for ER(+) breast cancer (P (common-effects) by ER status < .001). Total fruit consumption was non-statistically significantly associated with risk of ER(-) breast cancer (pooled multivariable RR comparing the highest vs lowest quintile = 0.94, 95% CI = 0.85 to 1.04). CONCLUSIONS: We observed no association between total fruit and vegetable intake and risk of overall breast cancer. However, vegetable consumption was inversely associated with risk of ER(-) breast cancer in our large pooled analyses. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/23349252/Fruit_and_vegetable_intake_and_risk_of_breast_cancer_by_hormone_receptor_status_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djs635 DB - PRIME DP - Unbound Medicine ER -