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Large scale screening of commonly used Iranian traditional medicinal plants against urease activity.
Daru 2012; 20(1):72DARU

Abstract

BACKGROUND AND PURPOSE OF THE STUDY

H. pylori infection is an important etiologic impetus usually leading to gastric disease and urease enzyme is the most crucial role is to protect the bacteria in the acidic environment of the stomach. Then urease inhibitors would increase sensitivity of the bacteria in acidic medium.

METHODS

137 Iranian traditional medicinal plants were examined against Jack bean urease activity by Berthelot reaction. Each herb was extracted using 50% aqueous methanol. The more effective extracts were further tested and their IC50 values were determined.

RESULTS

37 plants out of the 137 crude extracts revealed strong urease inhibitory activity (more than 70% inhibition against urease activity at 10 mg/ml concentration). Nine of the whole studied plants crude extracts were found as the most effective with IC50 values less than 500 μg/ml including; Rheum ribes, Sambucus ebulus, Pistachia lentiscus, Myrtus communis, Areca catechu, Citrus aurantifolia, Myristica fragrans, Cinnamomum zeylanicum and Nicotiana tabacum.

CONCLUSIONS

The most potent urease inhibitory was observed for Sambucus ebulus and Rheum ribes extracts with IC50 values of 57 and 92 μg/ml, respectively.

Authors+Show Affiliations

School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran. dr.yousefi@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23351780

Citation

Nabati, Farzaneh, et al. "Large Scale Screening of Commonly Used Iranian Traditional Medicinal Plants Against Urease Activity." Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences, vol. 20, no. 1, 2012, p. 72.
Nabati F, Mojab F, Habibi-Rezaei M, et al. Large scale screening of commonly used Iranian traditional medicinal plants against urease activity. Daru. 2012;20(1):72.
Nabati, F., Mojab, F., Habibi-Rezaei, M., Bagherzadeh, K., Amanlou, M., & Yousefi, B. (2012). Large scale screening of commonly used Iranian traditional medicinal plants against urease activity. Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 20(1), p. 72. doi:10.1186/2008-2231-20-72.
Nabati F, et al. Large Scale Screening of Commonly Used Iranian Traditional Medicinal Plants Against Urease Activity. Daru. 2012 Oct 31;20(1):72. PubMed PMID: 23351780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Large scale screening of commonly used Iranian traditional medicinal plants against urease activity. AU - Nabati,Farzaneh, AU - Mojab,Faraz, AU - Habibi-Rezaei,Mehran, AU - Bagherzadeh,Kowsar, AU - Amanlou,Massoud, AU - Yousefi,Behnam, Y1 - 2012/10/31/ PY - 2012/07/17/received PY - 2012/07/17/accepted PY - 2013/1/29/entrez PY - 2013/1/29/pubmed PY - 2013/1/29/medline SP - 72 EP - 72 JF - Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences JO - Daru VL - 20 IS - 1 N2 - BACKGROUND AND PURPOSE OF THE STUDY: H. pylori infection is an important etiologic impetus usually leading to gastric disease and urease enzyme is the most crucial role is to protect the bacteria in the acidic environment of the stomach. Then urease inhibitors would increase sensitivity of the bacteria in acidic medium. METHODS: 137 Iranian traditional medicinal plants were examined against Jack bean urease activity by Berthelot reaction. Each herb was extracted using 50% aqueous methanol. The more effective extracts were further tested and their IC50 values were determined. RESULTS: 37 plants out of the 137 crude extracts revealed strong urease inhibitory activity (more than 70% inhibition against urease activity at 10 mg/ml concentration). Nine of the whole studied plants crude extracts were found as the most effective with IC50 values less than 500 μg/ml including; Rheum ribes, Sambucus ebulus, Pistachia lentiscus, Myrtus communis, Areca catechu, Citrus aurantifolia, Myristica fragrans, Cinnamomum zeylanicum and Nicotiana tabacum. CONCLUSIONS: The most potent urease inhibitory was observed for Sambucus ebulus and Rheum ribes extracts with IC50 values of 57 and 92 μg/ml, respectively. SN - 1560-8115 UR - https://www.unboundmedicine.com/medline/citation/23351780/Large_scale_screening_of_commonly_used_Iranian_traditional_medicinal_plants_against_urease_activity_ L2 - https://darujps.biomedcentral.com/articles/10.1186/2008-2231-20-72 DB - PRIME DP - Unbound Medicine ER -