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High-resolution imaging of retinal nerve fiber bundles in glaucoma using adaptive optics scanning laser ophthalmoscopy.
Am J Ophthalmol. 2013 May; 155(5):870-81.AJ

Abstract

PURPOSE

To detect pathologic changes in retinal nerve fiber bundles in glaucomatous eyes seen on images obtained by adaptive optics (AO) scanning laser ophthalmoscopy (AO SLO).

DESIGN

Prospective cross-sectional study.

METHODS

Twenty-eight eyes of 28 patients with open-angle glaucoma and 21 normal eyes of 21 volunteer subjects underwent a full ophthalmologic examination, visual field testing using a Humphrey Field Analyzer, fundus photography, red-free SLO imaging, spectral-domain optical coherence tomography, and imaging with an original prototype AO SLO system.

RESULTS

The AO SLO images showed many hyperreflective bundles suggesting nerve fiber bundles. In glaucomatous eyes, the nerve fiber bundles were narrower than in normal eyes, and the nerve fiber layer thickness was correlated with the nerve fiber bundle widths on AO SLO (P < .001). In the nerve fiber layer defect area on fundus photography, the nerve fiber bundles on AO SLO were narrower compared with those in normal eyes (P < .001). At 60 degrees on the inferior temporal side of the optic disc, the nerve fiber bundle width was significantly lower, even in areas without nerve fiber layer defect, in eyes with glaucomatous eyes compared with normal eyes (P = .026). The mean deviations of each cluster in visual field testing were correlated with the corresponding nerve fiber bundle widths (P = .017).

CONCLUSIONS

AO SLO images showed reduced nerve fiber bundle widths both in clinically normal and abnormal areas of glaucomatous eyes, and these abnormalities were associated with visual field defects, suggesting that AO SLO may be useful for detecting early nerve fiber bundle abnormalities associated with loss of visual function.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23352341

Citation

Takayama, Kohei, et al. "High-resolution Imaging of Retinal Nerve Fiber Bundles in Glaucoma Using Adaptive Optics Scanning Laser Ophthalmoscopy." American Journal of Ophthalmology, vol. 155, no. 5, 2013, pp. 870-81.
Takayama K, Ooto S, Hangai M, et al. High-resolution imaging of retinal nerve fiber bundles in glaucoma using adaptive optics scanning laser ophthalmoscopy. Am J Ophthalmol. 2013;155(5):870-81.
Takayama, K., Ooto, S., Hangai, M., Ueda-Arakawa, N., Yoshida, S., Akagi, T., Ikeda, H. O., Nonaka, A., Hanebuchi, M., Inoue, T., & Yoshimura, N. (2013). High-resolution imaging of retinal nerve fiber bundles in glaucoma using adaptive optics scanning laser ophthalmoscopy. American Journal of Ophthalmology, 155(5), 870-81. https://doi.org/10.1016/j.ajo.2012.11.016
Takayama K, et al. High-resolution Imaging of Retinal Nerve Fiber Bundles in Glaucoma Using Adaptive Optics Scanning Laser Ophthalmoscopy. Am J Ophthalmol. 2013;155(5):870-81. PubMed PMID: 23352341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-resolution imaging of retinal nerve fiber bundles in glaucoma using adaptive optics scanning laser ophthalmoscopy. AU - Takayama,Kohei, AU - Ooto,Sotaro, AU - Hangai,Masanori, AU - Ueda-Arakawa,Naoko, AU - Yoshida,Sachiko, AU - Akagi,Tadamichi, AU - Ikeda,Hanako Ohashi, AU - Nonaka,Atsushi, AU - Hanebuchi,Masaaki, AU - Inoue,Takashi, AU - Yoshimura,Nagahisa, Y1 - 2013/01/23/ PY - 2012/07/08/received PY - 2012/11/08/revised PY - 2012/11/10/accepted PY - 2013/1/29/entrez PY - 2013/1/29/pubmed PY - 2013/6/5/medline SP - 870 EP - 81 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 155 IS - 5 N2 - PURPOSE: To detect pathologic changes in retinal nerve fiber bundles in glaucomatous eyes seen on images obtained by adaptive optics (AO) scanning laser ophthalmoscopy (AO SLO). DESIGN: Prospective cross-sectional study. METHODS: Twenty-eight eyes of 28 patients with open-angle glaucoma and 21 normal eyes of 21 volunteer subjects underwent a full ophthalmologic examination, visual field testing using a Humphrey Field Analyzer, fundus photography, red-free SLO imaging, spectral-domain optical coherence tomography, and imaging with an original prototype AO SLO system. RESULTS: The AO SLO images showed many hyperreflective bundles suggesting nerve fiber bundles. In glaucomatous eyes, the nerve fiber bundles were narrower than in normal eyes, and the nerve fiber layer thickness was correlated with the nerve fiber bundle widths on AO SLO (P < .001). In the nerve fiber layer defect area on fundus photography, the nerve fiber bundles on AO SLO were narrower compared with those in normal eyes (P < .001). At 60 degrees on the inferior temporal side of the optic disc, the nerve fiber bundle width was significantly lower, even in areas without nerve fiber layer defect, in eyes with glaucomatous eyes compared with normal eyes (P = .026). The mean deviations of each cluster in visual field testing were correlated with the corresponding nerve fiber bundle widths (P = .017). CONCLUSIONS: AO SLO images showed reduced nerve fiber bundle widths both in clinically normal and abnormal areas of glaucomatous eyes, and these abnormalities were associated with visual field defects, suggesting that AO SLO may be useful for detecting early nerve fiber bundle abnormalities associated with loss of visual function. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/23352341/High_resolution_imaging_of_retinal_nerve_fiber_bundles_in_glaucoma_using_adaptive_optics_scanning_laser_ophthalmoscopy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(12)00827-6 DB - PRIME DP - Unbound Medicine ER -