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A new cytotoxic quinolone alkaloid and a pentacyclic steroidal glycoside from the stem bark of Crataeva nurvala: study of anti-proliferative and apoptosis inducing property.
Eur J Med Chem. 2013 Feb; 60:490-6.EJ

Abstract

Chemical investigation of stem bark of Crataeva nurvala afforded 5,7-dimethoxy-3-phenyl-1-ethyl-1,4-dihydro-4-quinolone and a steroidal glycoside with unprecedented pentacyclic ring system named crataemine (1a) and crataenoside (2) respectively. The structures of the compounds were determined by spectroscopic analysis. A series of compounds with modification at position 1 of 1a (1a-1c) were prepared. All compounds were screened for cytotoxic activity against HeLa, PC-3 and MCF-7 cells. Only 1a and 2 showed potency against all three cells. Mechanism based study for activity of the compounds demonstrated that it could block the migration of more aggressive HeLa and PC-3 cells and prevent their colony formation ability as well. The compounds potentiated apoptosis in HeLa and PC-3 cells in a significant manner.

Authors+Show Affiliations

Amity Institute of Biotechnology, Amity University, Sector 125, Noida 201303, UP, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23354071

Citation

Sinha, Sadhna, et al. "A New Cytotoxic Quinolone Alkaloid and a Pentacyclic Steroidal Glycoside From the Stem Bark of Crataeva Nurvala: Study of Anti-proliferative and Apoptosis Inducing Property." European Journal of Medicinal Chemistry, vol. 60, 2013, pp. 490-6.
Sinha S, Mishra P, Amin H, et al. A new cytotoxic quinolone alkaloid and a pentacyclic steroidal glycoside from the stem bark of Crataeva nurvala: study of anti-proliferative and apoptosis inducing property. Eur J Med Chem. 2013;60:490-6.
Sinha, S., Mishra, P., Amin, H., Rah, B., Nayak, D., Goswami, A., Kumar, N., Vishwakarma, R., & Ghosal, S. (2013). A new cytotoxic quinolone alkaloid and a pentacyclic steroidal glycoside from the stem bark of Crataeva nurvala: study of anti-proliferative and apoptosis inducing property. European Journal of Medicinal Chemistry, 60, 490-6. https://doi.org/10.1016/j.ejmech.2012.12.017
Sinha S, et al. A New Cytotoxic Quinolone Alkaloid and a Pentacyclic Steroidal Glycoside From the Stem Bark of Crataeva Nurvala: Study of Anti-proliferative and Apoptosis Inducing Property. Eur J Med Chem. 2013;60:490-6. PubMed PMID: 23354071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new cytotoxic quinolone alkaloid and a pentacyclic steroidal glycoside from the stem bark of Crataeva nurvala: study of anti-proliferative and apoptosis inducing property. AU - Sinha,Sadhna, AU - Mishra,Priyanka, AU - Amin,Hina, AU - Rah,Bilal, AU - Nayak,Debasis, AU - Goswami,Anindya, AU - Kumar,Naresh, AU - Vishwakarma,Ram, AU - Ghosal,Sabari, Y1 - 2012/12/17/ PY - 2012/09/23/received PY - 2012/12/05/revised PY - 2012/12/08/accepted PY - 2013/1/29/entrez PY - 2013/1/29/pubmed PY - 2013/8/14/medline SP - 490 EP - 6 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 60 N2 - Chemical investigation of stem bark of Crataeva nurvala afforded 5,7-dimethoxy-3-phenyl-1-ethyl-1,4-dihydro-4-quinolone and a steroidal glycoside with unprecedented pentacyclic ring system named crataemine (1a) and crataenoside (2) respectively. The structures of the compounds were determined by spectroscopic analysis. A series of compounds with modification at position 1 of 1a (1a-1c) were prepared. All compounds were screened for cytotoxic activity against HeLa, PC-3 and MCF-7 cells. Only 1a and 2 showed potency against all three cells. Mechanism based study for activity of the compounds demonstrated that it could block the migration of more aggressive HeLa and PC-3 cells and prevent their colony formation ability as well. The compounds potentiated apoptosis in HeLa and PC-3 cells in a significant manner. SN - 1768-3254 UR - https://www.unboundmedicine.com/medline/citation/23354071/A_new_cytotoxic_quinolone_alkaloid_and_a_pentacyclic_steroidal_glycoside_from_the_stem_bark_of_Crataeva_nurvala:_study_of_anti_proliferative_and_apoptosis_inducing_property_ DB - PRIME DP - Unbound Medicine ER -