TY - JOUR T1 - A new cytotoxic quinolone alkaloid and a pentacyclic steroidal glycoside from the stem bark of Crataeva nurvala: study of anti-proliferative and apoptosis inducing property. AU - Sinha,Sadhna, AU - Mishra,Priyanka, AU - Amin,Hina, AU - Rah,Bilal, AU - Nayak,Debasis, AU - Goswami,Anindya, AU - Kumar,Naresh, AU - Vishwakarma,Ram, AU - Ghosal,Sabari, Y1 - 2012/12/17/ PY - 2012/09/23/received PY - 2012/12/05/revised PY - 2012/12/08/accepted PY - 2013/1/29/entrez PY - 2013/1/29/pubmed PY - 2013/8/14/medline SP - 490 EP - 6 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 60 N2 - Chemical investigation of stem bark of Crataeva nurvala afforded 5,7-dimethoxy-3-phenyl-1-ethyl-1,4-dihydro-4-quinolone and a steroidal glycoside with unprecedented pentacyclic ring system named crataemine (1a) and crataenoside (2) respectively. The structures of the compounds were determined by spectroscopic analysis. A series of compounds with modification at position 1 of 1a (1a-1c) were prepared. All compounds were screened for cytotoxic activity against HeLa, PC-3 and MCF-7 cells. Only 1a and 2 showed potency against all three cells. Mechanism based study for activity of the compounds demonstrated that it could block the migration of more aggressive HeLa and PC-3 cells and prevent their colony formation ability as well. The compounds potentiated apoptosis in HeLa and PC-3 cells in a significant manner. SN - 1768-3254 UR - https://www.unboundmedicine.com/medline/citation/23354071/A_new_cytotoxic_quinolone_alkaloid_and_a_pentacyclic_steroidal_glycoside_from_the_stem_bark_of_Crataeva_nurvala:_study_of_anti_proliferative_and_apoptosis_inducing_property_ DB - PRIME DP - Unbound Medicine ER -