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[Bone health in patients with anorexia nervosa].
Clin Calcium 2013; 23(2):263-9CC

Abstract

Osteoporosis associated with anorexia nervosa (AN) is common, and tends to be severe, slow to recover from, and sometimes irreversible. The abnormal bone metabolism in severely emaciated AN patients involves both a reduction in bone formation and an increase in bone resorption. The annual change in lumbar bone mineral density (BMD) is significantly correlated with BMI at the entry. The critical BMI for a positive increase in BMD was 16.4±0.3 kg/m(2). Nutritional improvement with body weight gain is the most important goal of treatment for AN-related osteoporosis since it increases both serum levels of insulin-like growth factor-I, a potent osteogenic factor, and estradiol, a powerful bone resorption inhibitor. However, it is difficult for AN patients to accept weight gain. About 50% of AN patients are insufficient of vitamin D and 43% show an increase in plasma undercalboxylated osteocalcin, indicating a deficiency state of the vitamin K(2). Vitamin D(3) or vitamin K(2) (menatetrenone) can prevent further bone loss in severely emaciated AN patients. Recently, bone strength has been evaluated by both BMD and bone quality. Plasma levels of homocysteine, a marker of degradation of bone quality, have significantly positive correlation with their ages of AN patients. We must evaluate bone density as well as bone quality in AN patients.

Authors+Show Affiliations

Health Services Center, National Graduate Institute for Policy Studies, Japan.

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

23354095

Citation

Suzuki, Mari Hotta. "[Bone Health in Patients With Anorexia Nervosa]." Clinical Calcium, vol. 23, no. 2, 2013, pp. 263-9.
Suzuki MH. [Bone health in patients with anorexia nervosa]. Clin Calcium. 2013;23(2):263-9.
Suzuki, M. H. (2013). [Bone health in patients with anorexia nervosa]. Clinical Calcium, 23(2), pp. 263-9. doi:CliCa1302263269.
Suzuki MH. [Bone Health in Patients With Anorexia Nervosa]. Clin Calcium. 2013;23(2):263-9. PubMed PMID: 23354095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bone health in patients with anorexia nervosa]. A1 - Suzuki,Mari Hotta, PY - 2013/1/29/entrez PY - 2013/1/29/pubmed PY - 2013/9/26/medline SP - 263 EP - 9 JF - Clinical calcium JO - Clin Calcium VL - 23 IS - 2 N2 - Osteoporosis associated with anorexia nervosa (AN) is common, and tends to be severe, slow to recover from, and sometimes irreversible. The abnormal bone metabolism in severely emaciated AN patients involves both a reduction in bone formation and an increase in bone resorption. The annual change in lumbar bone mineral density (BMD) is significantly correlated with BMI at the entry. The critical BMI for a positive increase in BMD was 16.4±0.3 kg/m(2). Nutritional improvement with body weight gain is the most important goal of treatment for AN-related osteoporosis since it increases both serum levels of insulin-like growth factor-I, a potent osteogenic factor, and estradiol, a powerful bone resorption inhibitor. However, it is difficult for AN patients to accept weight gain. About 50% of AN patients are insufficient of vitamin D and 43% show an increase in plasma undercalboxylated osteocalcin, indicating a deficiency state of the vitamin K(2). Vitamin D(3) or vitamin K(2) (menatetrenone) can prevent further bone loss in severely emaciated AN patients. Recently, bone strength has been evaluated by both BMD and bone quality. Plasma levels of homocysteine, a marker of degradation of bone quality, have significantly positive correlation with their ages of AN patients. We must evaluate bone density as well as bone quality in AN patients. SN - 0917-5857 UR - https://www.unboundmedicine.com/medline/citation/23354095/[Bone_health_in_patients_with_anorexia_nervosa]_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -