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Mucocutaneous manifestations and nail changes in patients with end-stage renal disease on hemodialysis.
Saudi J Kidney Dis Transpl 2013; 24(1):36-40SJ

Abstract

Mucocutaneous manifestations are common among patients on hemodialysis (HD). This study was undertaken to determine the prevalence of mucocutaneous manifestations in patients with end-stage renal disease (ESRD) who are on HD. In this cross-sectional, descriptive and analytic study conducted in 2009, 100 patients on HD at the Five Azar Hospital in Gorgan city were randomly selected. All the patients underwent detailed examination by a dermatologist to look for lesions in the skin, hair, nail and mucous membranes; if felt necessary, biopsy was obtained from the lesions. The findings were statistically analyzed using SPSS-13 software. For evaluation of normality of distribution, Kolmogorov-Smirnov was used, for quantitative variables Mann-Whitney and T-test (abnormal distribution) were used and for qualitative variables, Chi-2 and Fisher were used. In this study, P-value less than 0.05 was considered significant. Fifty-one males and 49 females were enrolled. The mean age was 49 ± 12 years. Diabetes was the most common cause of ESRD. In 95% of the patients, at least one mucocutaneous manifestation was present. Xerosis (78.3%) was the most common lesion, followed by pruritus (39.1%), lentigo (34.8%), skin discoloration (32.6%), leukonychia (32%) and thinning of the nail bed (24%). Xerosis, scaling, lentigo, folliculitis, idiopathic guttate hypopigmentation, leukonychia and half and half nail were associated with age. A significant relationship was seen between duration on dialysis and skin discoloration and leukonychia. Clubbing had a significant association with calcium-phosphorus product (Ca × P). There was a significant association between serum ferritin level and pruritus and tinea versicolor lesions. Our study shows that mucocutaneous manifestations are common among patients with ESRD. Identification of these manifestations and their association with causative factors are useful for preventing the lesions.

Authors+Show Affiliations

Department of Nephrology, Golestan University of Medical Sciences, Gorgan, Iran. tajbakhsh@goums.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23354189

Citation

Tajbakhsh, Ramin, et al. "Mucocutaneous Manifestations and Nail Changes in Patients With End-stage Renal Disease On Hemodialysis." Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol. 24, no. 1, 2013, pp. 36-40.
Tajbakhsh R, Dehghan M, Azarhoosh R, et al. Mucocutaneous manifestations and nail changes in patients with end-stage renal disease on hemodialysis. Saudi J Kidney Dis Transpl. 2013;24(1):36-40.
Tajbakhsh, R., Dehghan, M., Azarhoosh, R., Haghighi, A. N., Sadani, S., Zadeh, S. S., ... Qorbani, M. (2013). Mucocutaneous manifestations and nail changes in patients with end-stage renal disease on hemodialysis. Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 24(1), pp. 36-40.
Tajbakhsh R, et al. Mucocutaneous Manifestations and Nail Changes in Patients With End-stage Renal Disease On Hemodialysis. Saudi J Kidney Dis Transpl. 2013;24(1):36-40. PubMed PMID: 23354189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mucocutaneous manifestations and nail changes in patients with end-stage renal disease on hemodialysis. AU - Tajbakhsh,Ramin, AU - Dehghan,Mohammad, AU - Azarhoosh,Ramin, AU - Haghighi,Ali Nobakht, AU - Sadani,Somayeh, AU - Zadeh,Soheila Samad, AU - Kabootari,Maryam, AU - Qorbani,Mostafa, PY - 2013/1/29/entrez PY - 2013/1/29/pubmed PY - 2013/3/6/medline SP - 36 EP - 40 JF - Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia JO - Saudi J Kidney Dis Transpl VL - 24 IS - 1 N2 - Mucocutaneous manifestations are common among patients on hemodialysis (HD). This study was undertaken to determine the prevalence of mucocutaneous manifestations in patients with end-stage renal disease (ESRD) who are on HD. In this cross-sectional, descriptive and analytic study conducted in 2009, 100 patients on HD at the Five Azar Hospital in Gorgan city were randomly selected. All the patients underwent detailed examination by a dermatologist to look for lesions in the skin, hair, nail and mucous membranes; if felt necessary, biopsy was obtained from the lesions. The findings were statistically analyzed using SPSS-13 software. For evaluation of normality of distribution, Kolmogorov-Smirnov was used, for quantitative variables Mann-Whitney and T-test (abnormal distribution) were used and for qualitative variables, Chi-2 and Fisher were used. In this study, P-value less than 0.05 was considered significant. Fifty-one males and 49 females were enrolled. The mean age was 49 ± 12 years. Diabetes was the most common cause of ESRD. In 95% of the patients, at least one mucocutaneous manifestation was present. Xerosis (78.3%) was the most common lesion, followed by pruritus (39.1%), lentigo (34.8%), skin discoloration (32.6%), leukonychia (32%) and thinning of the nail bed (24%). Xerosis, scaling, lentigo, folliculitis, idiopathic guttate hypopigmentation, leukonychia and half and half nail were associated with age. A significant relationship was seen between duration on dialysis and skin discoloration and leukonychia. Clubbing had a significant association with calcium-phosphorus product (Ca × P). There was a significant association between serum ferritin level and pruritus and tinea versicolor lesions. Our study shows that mucocutaneous manifestations are common among patients with ESRD. Identification of these manifestations and their association with causative factors are useful for preventing the lesions. SN - 1319-2442 UR - https://www.unboundmedicine.com/medline/citation/23354189/Mucocutaneous_manifestations_and_nail_changes_in_patients_with_end_stage_renal_disease_on_hemodialysis_ L2 - http://www.sjkdt.org/article.asp?issn=1319-2442;year=2013;volume=24;issue=1;spage=36;epage=40;aulast=Tajbakhsh DB - PRIME DP - Unbound Medicine ER -