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Racial/ethnic differences in serum sex steroid hormone concentrations in US adolescent males.
Cancer Causes Control 2013; 24(4):817-26CC

Abstract

OBJECTIVE

Contrary to the hypothesis that the racial/ethnic disparity in prostate cancer has a hormonal basis, we did not observe a difference in serum testosterone concentration between non-Hispanic black and white men in the Third National Health and Nutrition Examination Survey (NHANES III), although non-Hispanic black men had a higher estradiol level. Unexpectedly, Mexican-American men had the highest testosterone level. Next, we evaluated whether the same patterns are observed during adolescence, the time of prostate maturation.

METHODS

We measured serum testosterone, estradiol, and sex hormone-binding globulin (SHBG) by immunoassay in 134 males aged 12-19 in NHANES III. Mean concentrations were compared by race/ethnicity adjusting for age, Tanner stage, percent body fat, waist, physical activity, tobacco smoke, and the other hormones.

RESULTS

After multivariable adjustment, in the 12-15-year-old males, testosterone concentration was lower in non-Hispanic blacks than whites (p = 0.043), SHBG concentration did not significantly differ between the two groups. Mexican-Americans had the highest testosterone (versus non-Hispanic black: p = 0.002) and lowest SHBG (versus non-Hispanic white: p = 0.010; versus non-Hispanic black: p = 0.047) concentrations. Estradiol concentration was lower in non-Hispanic blacks (p = 0.11) and Mexican-Americans (p = 0.033) compared with non-Hispanic whites. After multivariable adjustment, in the 16-19-year-old males, testosterone, estradiol, and SHBG concentrations did not differ between non-Hispanic blacks and whites. Mexican-Americans had the highest testosterone concentration (versus non-Hispanic white: p = 0.08), but did not differ from the other groups on estradiol and SHBG concentrations. In both age groups, these patterns were generally present, but less pronounced after adjusting for age and Tanner stage only.

CONCLUSION

In adolescent males, non-Hispanic blacks did not have a higher testosterone concentration than non-Hispanic whites, and Mexican-Americans had the highest testosterone concentration, patterns similar to adult males.

Authors+Show Affiliations

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. david.s.lopez@uth.tmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23354421

Citation

Lopez, David S., et al. "Racial/ethnic Differences in Serum Sex Steroid Hormone Concentrations in US Adolescent Males." Cancer Causes & Control : CCC, vol. 24, no. 4, 2013, pp. 817-26.
Lopez DS, Peskoe SB, Joshu CE, et al. Racial/ethnic differences in serum sex steroid hormone concentrations in US adolescent males. Cancer Causes Control. 2013;24(4):817-26.
Lopez, D. S., Peskoe, S. B., Joshu, C. E., Dobs, A., Feinleib, M., Kanarek, N., ... Platz, E. A. (2013). Racial/ethnic differences in serum sex steroid hormone concentrations in US adolescent males. Cancer Causes & Control : CCC, 24(4), pp. 817-26. doi:10.1007/s10552-013-0154-8.
Lopez DS, et al. Racial/ethnic Differences in Serum Sex Steroid Hormone Concentrations in US Adolescent Males. Cancer Causes Control. 2013;24(4):817-26. PubMed PMID: 23354421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Racial/ethnic differences in serum sex steroid hormone concentrations in US adolescent males. AU - Lopez,David S, AU - Peskoe,Sarah B, AU - Joshu,Corinne E, AU - Dobs,Adrian, AU - Feinleib,Manning, AU - Kanarek,Norma, AU - Nelson,William G, AU - Selvin,Elizabeth, AU - Rohrmann,Sabine, AU - Platz,Elizabeth A, Y1 - 2013/01/25/ PY - 2012/06/22/received PY - 2013/01/15/accepted PY - 2013/1/29/entrez PY - 2013/1/29/pubmed PY - 2013/9/13/medline SP - 817 EP - 26 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 24 IS - 4 N2 - OBJECTIVE: Contrary to the hypothesis that the racial/ethnic disparity in prostate cancer has a hormonal basis, we did not observe a difference in serum testosterone concentration between non-Hispanic black and white men in the Third National Health and Nutrition Examination Survey (NHANES III), although non-Hispanic black men had a higher estradiol level. Unexpectedly, Mexican-American men had the highest testosterone level. Next, we evaluated whether the same patterns are observed during adolescence, the time of prostate maturation. METHODS: We measured serum testosterone, estradiol, and sex hormone-binding globulin (SHBG) by immunoassay in 134 males aged 12-19 in NHANES III. Mean concentrations were compared by race/ethnicity adjusting for age, Tanner stage, percent body fat, waist, physical activity, tobacco smoke, and the other hormones. RESULTS: After multivariable adjustment, in the 12-15-year-old males, testosterone concentration was lower in non-Hispanic blacks than whites (p = 0.043), SHBG concentration did not significantly differ between the two groups. Mexican-Americans had the highest testosterone (versus non-Hispanic black: p = 0.002) and lowest SHBG (versus non-Hispanic white: p = 0.010; versus non-Hispanic black: p = 0.047) concentrations. Estradiol concentration was lower in non-Hispanic blacks (p = 0.11) and Mexican-Americans (p = 0.033) compared with non-Hispanic whites. After multivariable adjustment, in the 16-19-year-old males, testosterone, estradiol, and SHBG concentrations did not differ between non-Hispanic blacks and whites. Mexican-Americans had the highest testosterone concentration (versus non-Hispanic white: p = 0.08), but did not differ from the other groups on estradiol and SHBG concentrations. In both age groups, these patterns were generally present, but less pronounced after adjusting for age and Tanner stage only. CONCLUSION: In adolescent males, non-Hispanic blacks did not have a higher testosterone concentration than non-Hispanic whites, and Mexican-Americans had the highest testosterone concentration, patterns similar to adult males. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/23354421/Racial/ethnic_differences_in_serum_sex_steroid_hormone_concentrations_in_US_adolescent_males_ L2 - https://doi.org/10.1007/s10552-013-0154-8 DB - PRIME DP - Unbound Medicine ER -