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Physical and mental quality of life in chronic pancreatitis: a case-control study from the North American Pancreatitis Study 2 cohort.
Pancreas 2013; 42(2):293-300P

Abstract

OBJECTIVES

The objective of this study was to define the quality of life (QOL) in patients with chronic pancreatitis (CP).

METHODS

We studied 443 well-phenotyped CP subjects and 611 control subjects prospectively enrolled from 20 US centers between 2000 and 2006 in the North American Pancreatitis Study 2. Responses to the SF-12 questionnaire were used to calculate the mental (MCS) and physical component summary scores (PCS) with norm-based scoring (normal ≥50). Quality of life in CP subjects was compared with control subjects after controlling for demographic factors, drinking history, smoking, and medical conditions. Quality of life in CP was also compared with known scores for several chronic conditions.

RESULTS

Both PCS (38 [SD, 11.5] vs 52 [SD, 9.4]) and MCS (44 [SD, 11.5] vs 51 [SD, 9.2]) were significantly lower in CP compared with control subjects (P < 0.001). On multivariable analyses, compared with control subjects, a profound decrease in physical QOL (PCS 12.02 points lower) and a clinically significant decrease in mental QOL (MCS 4.24 points lower) was seen due to CP. Quality of life in CP was similar to (heart, kidney, liver, lung disease) or worse than (nonskin cancers, diabetes mellitus, hypertension, rheumatoid arthritis) other chronic conditions.

CONCLUSIONS

The impact of CP on QOL appears substantial. The QOL in CP subjects appears to be worse or similar to the QOL of many other chronic conditions.

Authors+Show Affiliations

North Mississippi Medical Center, Tupelo, MS 38801, USA. samann@nmhs.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23357924

Citation

Amann, Stephen T., et al. "Physical and Mental Quality of Life in Chronic Pancreatitis: a Case-control Study From the North American Pancreatitis Study 2 Cohort." Pancreas, vol. 42, no. 2, 2013, pp. 293-300.
Amann ST, Yadav D, Barmada MM, et al. Physical and mental quality of life in chronic pancreatitis: a case-control study from the North American Pancreatitis Study 2 cohort. Pancreas. 2013;42(2):293-300.
Amann, S. T., Yadav, D., Barmada, M. M., O'Connell, M., Kennard, E. D., Anderson, M., ... Whitcomb, D. C. (2013). Physical and mental quality of life in chronic pancreatitis: a case-control study from the North American Pancreatitis Study 2 cohort. Pancreas, 42(2), pp. 293-300. doi:10.1097/MPA.0b013e31826532e7.
Amann ST, et al. Physical and Mental Quality of Life in Chronic Pancreatitis: a Case-control Study From the North American Pancreatitis Study 2 Cohort. Pancreas. 2013;42(2):293-300. PubMed PMID: 23357924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical and mental quality of life in chronic pancreatitis: a case-control study from the North American Pancreatitis Study 2 cohort. AU - Amann,Stephen T, AU - Yadav,Dhiraj, AU - Barmada,M Micheal, AU - O'Connell,Michael, AU - Kennard,Elizabeth D, AU - Anderson,Michelle, AU - Baillie,John, AU - Sherman,Stuart, AU - Romagnuolo,Joseph, AU - Hawes,Robert H, AU - Alkaade,Samer, AU - Brand,Randall E, AU - Lewis,Michele D, AU - Gardner,Timothy B, AU - Gelrud,Andres, AU - Money,Mary E, AU - Banks,Peter A, AU - Slivka,Adam, AU - Whitcomb,David C, PY - 2013/1/30/entrez PY - 2013/1/30/pubmed PY - 2013/7/23/medline SP - 293 EP - 300 JF - Pancreas JO - Pancreas VL - 42 IS - 2 N2 - OBJECTIVES: The objective of this study was to define the quality of life (QOL) in patients with chronic pancreatitis (CP). METHODS: We studied 443 well-phenotyped CP subjects and 611 control subjects prospectively enrolled from 20 US centers between 2000 and 2006 in the North American Pancreatitis Study 2. Responses to the SF-12 questionnaire were used to calculate the mental (MCS) and physical component summary scores (PCS) with norm-based scoring (normal ≥50). Quality of life in CP subjects was compared with control subjects after controlling for demographic factors, drinking history, smoking, and medical conditions. Quality of life in CP was also compared with known scores for several chronic conditions. RESULTS: Both PCS (38 [SD, 11.5] vs 52 [SD, 9.4]) and MCS (44 [SD, 11.5] vs 51 [SD, 9.2]) were significantly lower in CP compared with control subjects (P < 0.001). On multivariable analyses, compared with control subjects, a profound decrease in physical QOL (PCS 12.02 points lower) and a clinically significant decrease in mental QOL (MCS 4.24 points lower) was seen due to CP. Quality of life in CP was similar to (heart, kidney, liver, lung disease) or worse than (nonskin cancers, diabetes mellitus, hypertension, rheumatoid arthritis) other chronic conditions. CONCLUSIONS: The impact of CP on QOL appears substantial. The QOL in CP subjects appears to be worse or similar to the QOL of many other chronic conditions. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/23357924/Physical_and_mental_quality_of_life_in_chronic_pancreatitis:_a_case_control_study_from_the_North_American_Pancreatitis_Study_2_cohort_ L2 - http://Insights.ovid.com/pubmed?pmid=23357924 DB - PRIME DP - Unbound Medicine ER -