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Monascus-fermented yellow pigments monascin and ankaflavin showed antiobesity effect via the suppression of differentiation and lipogenesis in obese rats fed a high-fat diet.
J Agric Food Chem. 2013 Feb 20; 61(7):1493-500.JA

Abstract

Monascus-fermented monascin and ankaflavin are found to strongly inhibit differentiation and lipogenesis and stimulate lipolysis effects in a 3T3-L1 preadipocyte model, but the in vivo regulation mechanism is unclear. This study uses obese rats caused by a high-fat diet to examine the effects of daily monascin and ankaflavin feeding (8 weeks) on antiobesity effects and modulation of differentiation, lipogenesis, and lipid absorption. The results show that monascin and ankaflavin had a significant antiobesity effect, which should result from the modulation of monascin and ankaflavin on the inhibition of differentiation by inhibiting CCAT/enhancer-binding protein β (C/EBPβ) expression (36.4% and 48.3%) and its downstream peroxisome proliferator-activated receptor γ (PPARγ) (55.6% and 64.5%) and CCAT/enhancer-binding protein α (C/EBPα) expressions (25.2% and 33.2%) and the inhibition of lipogenesis by increasing lipase activity (14.0% and 10.7%) and decreasing heparin releasable lipoprotein lipase (HR-LPL) activity (34.8% and 30.5%). Furthermore, monascin and ankaflavin are the first agents found to suppress Niemann-Pick C1 Like 1 (NPC1L1) protein expression (73.6% and 26.1%) associated with small intestine tissue lipid absorption. Importantly, monascin and ankaflavin are not like monacolin K, which increases creatine phosphokinase (CPK) activity, known as a rhabdomyolysis indicator.

Authors+Show Affiliations

Department of Life Science, National Taitung University, Taitung, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23360447

Citation

Lee, Chun-Lin, et al. "Monascus-fermented Yellow Pigments Monascin and Ankaflavin Showed Antiobesity Effect Via the Suppression of Differentiation and Lipogenesis in Obese Rats Fed a High-fat Diet." Journal of Agricultural and Food Chemistry, vol. 61, no. 7, 2013, pp. 1493-500.
Lee CL, Wen JY, Hsu YW, et al. Monascus-fermented yellow pigments monascin and ankaflavin showed antiobesity effect via the suppression of differentiation and lipogenesis in obese rats fed a high-fat diet. J Agric Food Chem. 2013;61(7):1493-500.
Lee, C. L., Wen, J. Y., Hsu, Y. W., & Pan, T. M. (2013). Monascus-fermented yellow pigments monascin and ankaflavin showed antiobesity effect via the suppression of differentiation and lipogenesis in obese rats fed a high-fat diet. Journal of Agricultural and Food Chemistry, 61(7), 1493-500. https://doi.org/10.1021/jf304015z
Lee CL, et al. Monascus-fermented Yellow Pigments Monascin and Ankaflavin Showed Antiobesity Effect Via the Suppression of Differentiation and Lipogenesis in Obese Rats Fed a High-fat Diet. J Agric Food Chem. 2013 Feb 20;61(7):1493-500. PubMed PMID: 23360447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monascus-fermented yellow pigments monascin and ankaflavin showed antiobesity effect via the suppression of differentiation and lipogenesis in obese rats fed a high-fat diet. AU - Lee,Chun-Lin, AU - Wen,Ja-Yan, AU - Hsu,Ya-Wen, AU - Pan,Tzu-Ming, Y1 - 2013/02/08/ PY - 2013/1/31/entrez PY - 2013/1/31/pubmed PY - 2014/1/24/medline SP - 1493 EP - 500 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 61 IS - 7 N2 - Monascus-fermented monascin and ankaflavin are found to strongly inhibit differentiation and lipogenesis and stimulate lipolysis effects in a 3T3-L1 preadipocyte model, but the in vivo regulation mechanism is unclear. This study uses obese rats caused by a high-fat diet to examine the effects of daily monascin and ankaflavin feeding (8 weeks) on antiobesity effects and modulation of differentiation, lipogenesis, and lipid absorption. The results show that monascin and ankaflavin had a significant antiobesity effect, which should result from the modulation of monascin and ankaflavin on the inhibition of differentiation by inhibiting CCAT/enhancer-binding protein β (C/EBPβ) expression (36.4% and 48.3%) and its downstream peroxisome proliferator-activated receptor γ (PPARγ) (55.6% and 64.5%) and CCAT/enhancer-binding protein α (C/EBPα) expressions (25.2% and 33.2%) and the inhibition of lipogenesis by increasing lipase activity (14.0% and 10.7%) and decreasing heparin releasable lipoprotein lipase (HR-LPL) activity (34.8% and 30.5%). Furthermore, monascin and ankaflavin are the first agents found to suppress Niemann-Pick C1 Like 1 (NPC1L1) protein expression (73.6% and 26.1%) associated with small intestine tissue lipid absorption. Importantly, monascin and ankaflavin are not like monacolin K, which increases creatine phosphokinase (CPK) activity, known as a rhabdomyolysis indicator. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/23360447/Monascus_fermented_yellow_pigments_monascin_and_ankaflavin_showed_antiobesity_effect_via_the_suppression_of_differentiation_and_lipogenesis_in_obese_rats_fed_a_high_fat_diet_ L2 - https://doi.org/10.1021/jf304015z DB - PRIME DP - Unbound Medicine ER -