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New inhibitors of α-glucosidase in Salacia hainanensis Chun et How.
J Nat Med. 2013 Oct; 67(4):844-9.JN

Abstract

The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24,26-dihydroxy-25-methoxy-tirucall-9-en-3-one (1), 2β,3β,22α-trihydroxy-lup-20(29)-ene (2) and 3β-hydroxy-2-carbonyl-lupan-29-oic acid (3), along with six known triterpenoids (4-9). Their structures were established on the basis of spectral analysis, in particular according to the data obtained by two-dimensional-NMR and high-resolution mass spectra experiments. Some of them showed much stronger inhibitory activity towards α-glucosidase than the positive control (acarbose, IC₅₀ 10.2 μM).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Guo ZH
Vocational and Technical School, Shenyang Pharmaceutical University, No.11-1, Beiyi Western Road, Tiexi District, Shenyang, 110026, China.
Huang J
No affiliation info available
Wan GS
No affiliation info available
Huo XL
No affiliation info available
Gao HY
No affiliation info available

MeSH

Enzyme InhibitorsGlycoside Hydrolase InhibitorsPlant RootsSalaciaTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23361306

Citation

Guo, Zheng-hong, et al. "New Inhibitors of Α-glucosidase in Salacia Hainanensis Chun Et How." Journal of Natural Medicines, vol. 67, no. 4, 2013, pp. 844-9.
Guo ZH, Huang J, Wan GS, et al. New inhibitors of α-glucosidase in Salacia hainanensis Chun et How. J Nat Med. 2013;67(4):844-9.
Guo, Z. H., Huang, J., Wan, G. S., Huo, X. L., & Gao, H. Y. (2013). New inhibitors of α-glucosidase in Salacia hainanensis Chun et How. Journal of Natural Medicines, 67(4), 844-9. https://doi.org/10.1007/s11418-013-0744-5
Guo ZH, et al. New Inhibitors of Α-glucosidase in Salacia Hainanensis Chun Et How. J Nat Med. 2013;67(4):844-9. PubMed PMID: 23361306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New inhibitors of α-glucosidase in Salacia hainanensis Chun et How. AU - Guo,Zheng-hong, AU - Huang,Jian, AU - Wan,Guo-sheng, AU - Huo,Xiao-ling, AU - Gao,Hui-yuan, Y1 - 2013/01/30/ PY - 2012/12/02/received PY - 2013/01/06/accepted PY - 2013/1/31/entrez PY - 2013/1/31/pubmed PY - 2014/3/29/medline SP - 844 EP - 9 JF - Journal of natural medicines JO - J Nat Med VL - 67 IS - 4 N2 - The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24,26-dihydroxy-25-methoxy-tirucall-9-en-3-one (1), 2β,3β,22α-trihydroxy-lup-20(29)-ene (2) and 3β-hydroxy-2-carbonyl-lupan-29-oic acid (3), along with six known triterpenoids (4-9). Their structures were established on the basis of spectral analysis, in particular according to the data obtained by two-dimensional-NMR and high-resolution mass spectra experiments. Some of them showed much stronger inhibitory activity towards α-glucosidase than the positive control (acarbose, IC₅₀ 10.2 μM). SN - 1861-0293 UR - https://www.unboundmedicine.com/medline/citation/23361306/New_inhibitors_of_α_glucosidase_in_Salacia_hainanensis_Chun_et_How_ L2 - https://dx.doi.org/10.1007/s11418-013-0744-5 DB - PRIME DP - Unbound Medicine ER -