Tags

Type your tag names separated by a space and hit enter

A randomized controlled trial of mindfulness-based stress reduction for women with early-stage breast cancer receiving radiotherapy.
Integr Cancer Ther 2013; 12(5):404-13IC

Abstract

PURPOSE

To testthe relative effectiveness of a mindfulness-based stress reduction program (MBSR) compared with a nutrition education intervention (NEP) and usual care (UC) in women with newly diagnosed early-stage breast cancer (BrCA)undergoing radiotherapy.

METHODS

Datawere available from a randomized controlled trialof 172 women, 20 to 65 years old, with stage I or II BrCA. Data from women completing the 8-week MBSR program plus 3 additional sessions focuses on special needs associated with BrCA were compared to women receiving attention control NEP and UC. Follow-up was performed at 3 post-intervention points: 4 months, and 1 and 2 years. Standardized, validated self-administered questionnaires were used to assess psychosocial variables. Descriptive analyses compared women by randomization assignment. Regression analyses, incorporating both intention-to-treat and post hoc multivariable approaches, were used to control for potential confounding variables.

RESULTS

A subset of 120 women underwent radiotherapy; 77 completed treatment prior to the study, and 40 had radiotherapy during the MBSR intervention. Women who actively received radiotherapy (art) while participating in the MBSR intervention (MBSR-art) experienced a significant (P < .05) improvement in 16 psychosocial variables compared with the NEP-art, UC-art, or both at 4 months. These included health-related, BrCA-specific quality of life and psychosocial coping, which were the primary outcomes, and secondary measures, including meaningfulness, helplessness, cognitive avoidance, depression, paranoid ideation, hostility, anxiety, global severity, anxious preoccupation, and emotional control.

CONCLUSIONS

MBSR appears to facilitate psychosocial adjustment in BrCA patients receiving radiotherapy, suggesting applicability for MBSR as adjunctive therapy in oncological practice.

Authors+Show Affiliations

University of South Carolina, Columbia, SC 29208, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23362338

Citation

Henderson, Virginia P., et al. "A Randomized Controlled Trial of Mindfulness-based Stress Reduction for Women With Early-stage Breast Cancer Receiving Radiotherapy." Integrative Cancer Therapies, vol. 12, no. 5, 2013, pp. 404-13.
Henderson VP, Massion AO, Clemow L, et al. A randomized controlled trial of mindfulness-based stress reduction for women with early-stage breast cancer receiving radiotherapy. Integr Cancer Ther. 2013;12(5):404-13.
Henderson, V. P., Massion, A. O., Clemow, L., Hurley, T. G., Druker, S., & Hébert, J. R. (2013). A randomized controlled trial of mindfulness-based stress reduction for women with early-stage breast cancer receiving radiotherapy. Integrative Cancer Therapies, 12(5), pp. 404-13. doi:10.1177/1534735412473640.
Henderson VP, et al. A Randomized Controlled Trial of Mindfulness-based Stress Reduction for Women With Early-stage Breast Cancer Receiving Radiotherapy. Integr Cancer Ther. 2013;12(5):404-13. PubMed PMID: 23362338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized controlled trial of mindfulness-based stress reduction for women with early-stage breast cancer receiving radiotherapy. AU - Henderson,Virginia P, AU - Massion,Ann O, AU - Clemow,Lynn, AU - Hurley,Thomas G, AU - Druker,Susan, AU - Hébert,James R, Y1 - 2013/01/28/ PY - 2013/1/31/entrez PY - 2013/1/31/pubmed PY - 2014/4/1/medline KW - breast cancer KW - mindfulness-based stress reduction program KW - psychosocial intervention KW - quality of life KW - radiation therapy KW - radiotherapy SP - 404 EP - 13 JF - Integrative cancer therapies JO - Integr Cancer Ther VL - 12 IS - 5 N2 - PURPOSE: To testthe relative effectiveness of a mindfulness-based stress reduction program (MBSR) compared with a nutrition education intervention (NEP) and usual care (UC) in women with newly diagnosed early-stage breast cancer (BrCA)undergoing radiotherapy. METHODS: Datawere available from a randomized controlled trialof 172 women, 20 to 65 years old, with stage I or II BrCA. Data from women completing the 8-week MBSR program plus 3 additional sessions focuses on special needs associated with BrCA were compared to women receiving attention control NEP and UC. Follow-up was performed at 3 post-intervention points: 4 months, and 1 and 2 years. Standardized, validated self-administered questionnaires were used to assess psychosocial variables. Descriptive analyses compared women by randomization assignment. Regression analyses, incorporating both intention-to-treat and post hoc multivariable approaches, were used to control for potential confounding variables. RESULTS: A subset of 120 women underwent radiotherapy; 77 completed treatment prior to the study, and 40 had radiotherapy during the MBSR intervention. Women who actively received radiotherapy (art) while participating in the MBSR intervention (MBSR-art) experienced a significant (P < .05) improvement in 16 psychosocial variables compared with the NEP-art, UC-art, or both at 4 months. These included health-related, BrCA-specific quality of life and psychosocial coping, which were the primary outcomes, and secondary measures, including meaningfulness, helplessness, cognitive avoidance, depression, paranoid ideation, hostility, anxiety, global severity, anxious preoccupation, and emotional control. CONCLUSIONS: MBSR appears to facilitate psychosocial adjustment in BrCA patients receiving radiotherapy, suggesting applicability for MBSR as adjunctive therapy in oncological practice. SN - 1552-695X UR - https://www.unboundmedicine.com/medline/citation/23362338/A_randomized_controlled_trial_of_mindfulness_based_stress_reduction_for_women_with_early_stage_breast_cancer_receiving_radiotherapy_ L2 - http://journals.sagepub.com/doi/full/10.1177/1534735412473640?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -