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Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats.
Addict Biol. 2013 Sep; 18(5):786-99.AB

Abstract

Recreational use of the drug 4-methylmethcathinone (mephedrone; 4-MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption of 4-MMC and cautions for recreational users about its addictive potential have appeared on Internet forums, very little information about abuse liability for this drug is available. This study was conducted to determine if 4-MMC serves as a reinforcer in a traditional intravenous self-administration model. Groups of male Wistar and Sprague-Dawley rats were prepared with intravenous catheters and trained to self-administer 4-MMC in 1-hour sessions. Per-infusion doses of 0.5 and 1.0 mg/kg were consistently self-administered, resulting in greater than 80% discrimination for the drug-paired lever and mean intakes of about 2-3 mg/kg/hour. Dose-substitution studies after acquisition demonstrated that the number of responses and/or the total amount of drug self-administered varied as a function of dose. In addition, radiotelemetry devices were used to show that self-administered 4-MMC was capable of increasing locomotor activity (Wistar) and decreasing body temperature (Sprague-Dawley). Pharmacokinetic studies found that the T1/2 of 4-MMC was about 1 hour in vivo in rat plasma and 90 minutes using in vitro liver microsomal assays. This study provides evidence of stimulant-typical abuse liability for 4-MMC in the traditional pre-clinical self-administration model.

Authors+Show Affiliations

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

23363010

Citation

Aarde, Shawn M., et al. "Mephedrone (4-methylmethcathinone) Supports Intravenous Self-administration in Sprague-Dawley and Wistar Rats." Addiction Biology, vol. 18, no. 5, 2013, pp. 786-99.
Aarde SM, Angrish D, Barlow DJ, et al. Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats. Addict Biol. 2013;18(5):786-99.
Aarde, S. M., Angrish, D., Barlow, D. J., Wright, M. J., Vandewater, S. A., Creehan, K. M., Houseknecht, K. L., Dickerson, T. J., & Taffe, M. A. (2013). Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats. Addiction Biology, 18(5), 786-99. https://doi.org/10.1111/adb.12038
Aarde SM, et al. Mephedrone (4-methylmethcathinone) Supports Intravenous Self-administration in Sprague-Dawley and Wistar Rats. Addict Biol. 2013;18(5):786-99. PubMed PMID: 23363010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats. AU - Aarde,Shawn M, AU - Angrish,Deepshikha, AU - Barlow,Deborah J, AU - Wright,M Jerry,Jr AU - Vandewater,Sophia A, AU - Creehan,Kevin M, AU - Houseknecht,Karen L, AU - Dickerson,Tobin J, AU - Taffe,Michael A, Y1 - 2013/01/30/ PY - 2013/2/1/entrez PY - 2013/2/1/pubmed PY - 2014/3/13/medline KW - Cathinone KW - reinforcement KW - stimulant KW - thermoregulation SP - 786 EP - 99 JF - Addiction biology JO - Addict Biol VL - 18 IS - 5 N2 - Recreational use of the drug 4-methylmethcathinone (mephedrone; 4-MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption of 4-MMC and cautions for recreational users about its addictive potential have appeared on Internet forums, very little information about abuse liability for this drug is available. This study was conducted to determine if 4-MMC serves as a reinforcer in a traditional intravenous self-administration model. Groups of male Wistar and Sprague-Dawley rats were prepared with intravenous catheters and trained to self-administer 4-MMC in 1-hour sessions. Per-infusion doses of 0.5 and 1.0 mg/kg were consistently self-administered, resulting in greater than 80% discrimination for the drug-paired lever and mean intakes of about 2-3 mg/kg/hour. Dose-substitution studies after acquisition demonstrated that the number of responses and/or the total amount of drug self-administered varied as a function of dose. In addition, radiotelemetry devices were used to show that self-administered 4-MMC was capable of increasing locomotor activity (Wistar) and decreasing body temperature (Sprague-Dawley). Pharmacokinetic studies found that the T1/2 of 4-MMC was about 1 hour in vivo in rat plasma and 90 minutes using in vitro liver microsomal assays. This study provides evidence of stimulant-typical abuse liability for 4-MMC in the traditional pre-clinical self-administration model. SN - 1369-1600 UR - https://www.unboundmedicine.com/medline/citation/23363010/Mephedrone__4_methylmethcathinone__supports_intravenous_self_administration_in_Sprague_Dawley_and_Wistar_rats_ L2 - https://doi.org/10.1111/adb.12038 DB - PRIME DP - Unbound Medicine ER -