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Disturbed sleep in Parkinson's disease: anatomical and pathological correlates.
Neuropathol Appl Neurobiol. 2013 Oct; 39(6):644-53.NA

Abstract

AIMS

Abnormal sleep is a common feature of Parkinson's disease (PD) and prodromal disorders of sleep are frequent (e.g. restless legs syndrome and rapid eye movement sleep behaviour disorder). However, the exact pathological basis of disturbed sleep remains as yet undefined.

METHODS

To investigate this further, 32 PD cases were stratified into three groups: (1) PD with disturbed sleep, PD(S); (2) PD with dementia (PDD) and disturbed sleep, PDD(S); and (3) PD without disturbed sleep, PD(nS). The extent of α-synuclein (αSyn) and Alzheimer disease (AD)-type pathology [amyloid β peptide (Aβ) and tau] was assessed in 15 regions of the PD brain.

RESULTS

The results demonstrate a significant association between disturbed sleep in PD and αSyn pathology in specific brainstem [locus coeruleus (P = 0.006) and raphe nuclei (P = 0.02)], hypothalamic [paramammillary nuclei (P = 0.04) and posterior nucleus (P = 0.02)], subcortical/limbic [amygdala (P = 0.03), thalamus (P = 0.01)] and cortical [entorhinal cortex (P = 0.01)] regions. A statistically significant increase of tau pathology was observed in the amygdala (P = 0.03), CA2 sector of the hippocampus (P = 0.01) and entorhinal cortex (P = 0.04) in PD cases with disturbed sleep.

CONCLUSIONS

Pathological changes in these structures, residing in the brain circuitry relating to sleep physiology, strongly predict the presence of sleep disturbances in PD.

Authors+Show Affiliations

Neuropathology Unit, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23363035

Citation

Kalaitzakis, M E., et al. "Disturbed Sleep in Parkinson's Disease: Anatomical and Pathological Correlates." Neuropathology and Applied Neurobiology, vol. 39, no. 6, 2013, pp. 644-53.
Kalaitzakis ME, Gentleman SM, Pearce RK. Disturbed sleep in Parkinson's disease: anatomical and pathological correlates. Neuropathol Appl Neurobiol. 2013;39(6):644-53.
Kalaitzakis, M. E., Gentleman, S. M., & Pearce, R. K. (2013). Disturbed sleep in Parkinson's disease: anatomical and pathological correlates. Neuropathology and Applied Neurobiology, 39(6), 644-53. https://doi.org/10.1111/nan.12024
Kalaitzakis ME, Gentleman SM, Pearce RK. Disturbed Sleep in Parkinson's Disease: Anatomical and Pathological Correlates. Neuropathol Appl Neurobiol. 2013;39(6):644-53. PubMed PMID: 23363035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disturbed sleep in Parkinson's disease: anatomical and pathological correlates. AU - Kalaitzakis,M E, AU - Gentleman,S M, AU - Pearce,R K B, PY - 2012/04/02/received PY - 2013/01/23/accepted PY - 2013/2/1/entrez PY - 2013/2/1/pubmed PY - 2014/4/11/medline KW - Lewy body disease KW - Parkinson's disease KW - dementia KW - neuropathology KW - sleep SP - 644 EP - 53 JF - Neuropathology and applied neurobiology JO - Neuropathol Appl Neurobiol VL - 39 IS - 6 N2 - AIMS: Abnormal sleep is a common feature of Parkinson's disease (PD) and prodromal disorders of sleep are frequent (e.g. restless legs syndrome and rapid eye movement sleep behaviour disorder). However, the exact pathological basis of disturbed sleep remains as yet undefined. METHODS: To investigate this further, 32 PD cases were stratified into three groups: (1) PD with disturbed sleep, PD(S); (2) PD with dementia (PDD) and disturbed sleep, PDD(S); and (3) PD without disturbed sleep, PD(nS). The extent of α-synuclein (αSyn) and Alzheimer disease (AD)-type pathology [amyloid β peptide (Aβ) and tau] was assessed in 15 regions of the PD brain. RESULTS: The results demonstrate a significant association between disturbed sleep in PD and αSyn pathology in specific brainstem [locus coeruleus (P = 0.006) and raphe nuclei (P = 0.02)], hypothalamic [paramammillary nuclei (P = 0.04) and posterior nucleus (P = 0.02)], subcortical/limbic [amygdala (P = 0.03), thalamus (P = 0.01)] and cortical [entorhinal cortex (P = 0.01)] regions. A statistically significant increase of tau pathology was observed in the amygdala (P = 0.03), CA2 sector of the hippocampus (P = 0.01) and entorhinal cortex (P = 0.04) in PD cases with disturbed sleep. CONCLUSIONS: Pathological changes in these structures, residing in the brain circuitry relating to sleep physiology, strongly predict the presence of sleep disturbances in PD. SN - 1365-2990 UR - https://www.unboundmedicine.com/medline/citation/23363035/Disturbed_sleep_in_Parkinson's_disease:_anatomical_and_pathological_correlates_ L2 - https://doi.org/10.1111/nan.12024 DB - PRIME DP - Unbound Medicine ER -