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Short-term and long-term mortality associated with ventricular arrhythmia in patients hospitalized with acute coronary syndrome: findings from the Gulf RACE registry-2.
Coron Artery Dis. 2013 Mar; 24(2):160-4.CA

Abstract

OBJECTIVES

Ventricular arrhythmia (VA) in the setting of acute coronary syndrome (ACS) carries an ominous prognosis; however, long-term prognosis associated with VA in ACS in the Middle East is unknown. Accordingly, we sought to assess the incidence, in-hospital outcomes, and 1-year mortality of in-hospital VA in patients with ACS.

METHODS AND RESULTS

The Second Gulf Registry of Acute Coronary Events (Gulf RACE-2) is a multinational observational study of patients with ACS, which enrolled 7930 patients. Of these, 333 (4.2%) developed VA during hospitalization. Patients with VA were significantly older (mean age 58.3 vs. 56.8 years), and had a significantly higher rate of prior stroke/transient ischemic attack (7.5 vs. 4.2%), smoking (36.6 vs. 35.6%), congestive heart failure (11.0 vs. 6.5%), and peripheral artery disease (6.5 vs. 1.7%), compared with patients without VA. They had significantly less diabetes mellitus (35.4 vs. 40.3%), hypertension (43.2 vs. 47.9%), percutaneous coronary intervention (6.1 vs. 9.4%), and dyslipidemia (22.4 vs. 38.2%). The adjusted odds ratios for in-hospital, 30-day, and 1-year mortality in VA complicating all ACS were 25.8, 11.1, and 7.3; ST-elevation myocardial infarctions were 18.3, 11.7, and 6.3; and unstable angina and non-ST elevation myocardial infarctions were 47.4, 10.3, and 18.7, respectively (all P<0.001).

CONCLUSION

In-hospital VA in patients with ACS with and without ST elevation was associated with significantly higher in-hospital, 30-day, and 1-year mortality. Noticeably higher long-term mortality among Middle Eastern patients with ACS having VA compared with other reports requires further study and warrants immediate attention.

Authors+Show Affiliations

Department of Cardiac Sciences, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. ahersi@ksu.edu.saNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23363987

Citation

Hersi, Ahmad, et al. "Short-term and Long-term Mortality Associated With Ventricular Arrhythmia in Patients Hospitalized With Acute Coronary Syndrome: Findings From the Gulf RACE Registry-2." Coronary Artery Disease, vol. 24, no. 2, 2013, pp. 160-4.
Hersi A, Alhabib KF, Alsheikh-Ali AA, et al. Short-term and long-term mortality associated with ventricular arrhythmia in patients hospitalized with acute coronary syndrome: findings from the Gulf RACE registry-2. Coron Artery Dis. 2013;24(2):160-4.
Hersi, A., Alhabib, K. F., Alsheikh-Ali, A. A., Sulaiman, K., Alfaleh, H. F., Alsaif, S., Al-Mahmeed, W., Asaad, N., Amin, H., Al-Motarreb, A., & Al Suwaidi, J. (2013). Short-term and long-term mortality associated with ventricular arrhythmia in patients hospitalized with acute coronary syndrome: findings from the Gulf RACE registry-2. Coronary Artery Disease, 24(2), 160-4. https://doi.org/10.1097/MCA.0b013e32835c49ed
Hersi A, et al. Short-term and Long-term Mortality Associated With Ventricular Arrhythmia in Patients Hospitalized With Acute Coronary Syndrome: Findings From the Gulf RACE Registry-2. Coron Artery Dis. 2013;24(2):160-4. PubMed PMID: 23363987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term and long-term mortality associated with ventricular arrhythmia in patients hospitalized with acute coronary syndrome: findings from the Gulf RACE registry-2. AU - Hersi,Ahmad, AU - Alhabib,Khalid F, AU - Alsheikh-Ali,Alawi A, AU - Sulaiman,Kadhim, AU - Alfaleh,Hussam F, AU - Alsaif,Shukri, AU - Al-Mahmeed,Wael, AU - Asaad,Nidal, AU - Amin,Haitham, AU - Al-Motarreb,Ahmed, AU - Al Suwaidi,Jassim, PY - 2013/2/1/entrez PY - 2013/2/1/pubmed PY - 2013/8/24/medline SP - 160 EP - 4 JF - Coronary artery disease JO - Coron. Artery Dis. VL - 24 IS - 2 N2 - OBJECTIVES: Ventricular arrhythmia (VA) in the setting of acute coronary syndrome (ACS) carries an ominous prognosis; however, long-term prognosis associated with VA in ACS in the Middle East is unknown. Accordingly, we sought to assess the incidence, in-hospital outcomes, and 1-year mortality of in-hospital VA in patients with ACS. METHODS AND RESULTS: The Second Gulf Registry of Acute Coronary Events (Gulf RACE-2) is a multinational observational study of patients with ACS, which enrolled 7930 patients. Of these, 333 (4.2%) developed VA during hospitalization. Patients with VA were significantly older (mean age 58.3 vs. 56.8 years), and had a significantly higher rate of prior stroke/transient ischemic attack (7.5 vs. 4.2%), smoking (36.6 vs. 35.6%), congestive heart failure (11.0 vs. 6.5%), and peripheral artery disease (6.5 vs. 1.7%), compared with patients without VA. They had significantly less diabetes mellitus (35.4 vs. 40.3%), hypertension (43.2 vs. 47.9%), percutaneous coronary intervention (6.1 vs. 9.4%), and dyslipidemia (22.4 vs. 38.2%). The adjusted odds ratios for in-hospital, 30-day, and 1-year mortality in VA complicating all ACS were 25.8, 11.1, and 7.3; ST-elevation myocardial infarctions were 18.3, 11.7, and 6.3; and unstable angina and non-ST elevation myocardial infarctions were 47.4, 10.3, and 18.7, respectively (all P<0.001). CONCLUSION: In-hospital VA in patients with ACS with and without ST elevation was associated with significantly higher in-hospital, 30-day, and 1-year mortality. Noticeably higher long-term mortality among Middle Eastern patients with ACS having VA compared with other reports requires further study and warrants immediate attention. SN - 1473-5830 UR - https://www.unboundmedicine.com/medline/citation/23363987/Short_term_and_long_term_mortality_associated_with_ventricular_arrhythmia_in_patients_hospitalized_with_acute_coronary_syndrome:_findings_from_the_Gulf_RACE_registry_2_ L2 - http://dx.doi.org/10.1097/MCA.0b013e32835c49ed DB - PRIME DP - Unbound Medicine ER -