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Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort.
Am J Clin Nutr. 2013 Mar; 97(3):517-23.AJ

Abstract

BACKGROUND

It has been extensively shown, mainly in US populations, that sugar-sweetened beverages (SSBs) are associated with increased risk of type 2 diabetes (T2D), but less is known about the effects of artificially sweetened beverages (ASBs).

OBJECTIVE

We evaluated the association between self-reported SSB, ASB, and 100% fruit juice consumption and T2D risk over 14 y of follow-up in the French prospective Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort.

DESIGN

A total of 66,118 women were followed from 1993, and 1369 incident cases of T2D were diagnosed during the follow-up. Cox regression models were used to estimate HRs and 95% CIs for T2D risk.

RESULTS

The average consumption of sweetened beverages in consumers was 328 and 568 mL/wk for SSBs and ASBs, respectively. Compared with nonconsumers, women in the highest quartiles of SSB and ASB consumers were at increased risk of T2D with HRs (95% CIs) of 1.34 (1.05, 1.71) and 2.21 (1.56, 3.14) for women who consumed >359 and >603 mL/wk of SSBs and ASBs, respectively. Strong positive trends in T2D risk were also observed across quartiles of consumption for both types of beverage (P = 0.0088 and P < 0.0001, respectively). In sensitivity analyses, associations were partly mediated by BMI, although there was still a strong significant independent effect. No association was observed for 100% fruit juice consumption.

CONCLUSIONS

Both SSB consumption and ASB consumption were associated with increased T2D risk. We cannot rule out that factors other than ASB consumption that we did not control for are responsible for the association with diabetes, and randomized trials are required to prove a causal link between ASB consumption and T2D.

Authors+Show Affiliations

Center for Research in Epidemiology and Population Health, Villejuif, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23364017

Citation

Fagherazzi, Guy, et al. "Consumption of Artificially and Sugar-sweetened Beverages and Incident Type 2 Diabetes in the Etude Epidemiologique Aupres Des Femmes De La Mutuelle Generale De l'Education Nationale-European Prospective Investigation Into Cancer and Nutrition Cohort." The American Journal of Clinical Nutrition, vol. 97, no. 3, 2013, pp. 517-23.
Fagherazzi G, Vilier A, Saes Sartorelli D, et al. Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr. 2013;97(3):517-23.
Fagherazzi, G., Vilier, A., Saes Sartorelli, D., Lajous, M., Balkau, B., & Clavel-Chapelon, F. (2013). Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort. The American Journal of Clinical Nutrition, 97(3), 517-23. https://doi.org/10.3945/ajcn.112.050997
Fagherazzi G, et al. Consumption of Artificially and Sugar-sweetened Beverages and Incident Type 2 Diabetes in the Etude Epidemiologique Aupres Des Femmes De La Mutuelle Generale De l'Education Nationale-European Prospective Investigation Into Cancer and Nutrition Cohort. Am J Clin Nutr. 2013;97(3):517-23. PubMed PMID: 23364017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort. AU - Fagherazzi,Guy, AU - Vilier,Alice, AU - Saes Sartorelli,Daniela, AU - Lajous,Martin, AU - Balkau,Beverley, AU - Clavel-Chapelon,Françoise, Y1 - 2013/01/30/ PY - 2013/2/1/entrez PY - 2013/2/1/pubmed PY - 2013/4/16/medline SP - 517 EP - 23 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 97 IS - 3 N2 - BACKGROUND: It has been extensively shown, mainly in US populations, that sugar-sweetened beverages (SSBs) are associated with increased risk of type 2 diabetes (T2D), but less is known about the effects of artificially sweetened beverages (ASBs). OBJECTIVE: We evaluated the association between self-reported SSB, ASB, and 100% fruit juice consumption and T2D risk over 14 y of follow-up in the French prospective Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort. DESIGN: A total of 66,118 women were followed from 1993, and 1369 incident cases of T2D were diagnosed during the follow-up. Cox regression models were used to estimate HRs and 95% CIs for T2D risk. RESULTS: The average consumption of sweetened beverages in consumers was 328 and 568 mL/wk for SSBs and ASBs, respectively. Compared with nonconsumers, women in the highest quartiles of SSB and ASB consumers were at increased risk of T2D with HRs (95% CIs) of 1.34 (1.05, 1.71) and 2.21 (1.56, 3.14) for women who consumed >359 and >603 mL/wk of SSBs and ASBs, respectively. Strong positive trends in T2D risk were also observed across quartiles of consumption for both types of beverage (P = 0.0088 and P < 0.0001, respectively). In sensitivity analyses, associations were partly mediated by BMI, although there was still a strong significant independent effect. No association was observed for 100% fruit juice consumption. CONCLUSIONS: Both SSB consumption and ASB consumption were associated with increased T2D risk. We cannot rule out that factors other than ASB consumption that we did not control for are responsible for the association with diabetes, and randomized trials are required to prove a causal link between ASB consumption and T2D. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/23364017/Consumption_of_artificially_and_sugar_sweetened_beverages_and_incident_type_2_diabetes_in_the_Etude_Epidemiologique_aupres_des_femmes_de_la_Mutuelle_Generale_de_l'Education_Nationale_European_Prospective_Investigation_into_Cancer_and_Nutrition_cohort_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.050997 DB - PRIME DP - Unbound Medicine ER -