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The influence of renal function on vitamin D metabolism in the very elderly.
J Nutr Health Aging. 2013 Feb; 17(2):107-11.JN

Abstract

OBJECTIVES

Hypovitaminosis D and chronic kidney disease (CKD) are highly prevalent in older adults. The factors correlating with 25-OH-vitamin D and PTH levels were analyzed in older adults with and without CKD.

DESIGN

We performed a cross-sectional analysis embedded within the BELFRAIL study.

SETTING

A population-based prospective cohort study of the very elderly in Belgium.

PARTICIPANTS

325 participants, all aged 80 or older.

MEASURMENTS

Time of year and LAPAQ score were used as proxies for sunshine exposure. Vitamin D3 supplementation, gender, institutionalisation, age, level of education, and serum calcium and phosphorus level were examined as possible confounders in the analyses.

RESULTS

There was no correlation between the presence of CKD and low 25-OH-vitamin D levels, but there was a significant (p<0.01) correlation between CKD and high PTH levels. Among the participants with a normal eGFR, the LAPACQ score, vitamin D supplementation, season, log PTH value and eGFR were correlated with log 25-OH-vitamin D levels. Among the participants with CKD, only vitamin D supplementation, log PTH levels and serum calcium levels were correlated with log 25-OH-vitamin D levels. Gender, log 25-OH-vitamin D values, serum calcium and phosphorus levels and eGFR were correlated with log PTH values in the patients with normal eGFR. Log 25-OH-vitamin D values, serum phosphorus levels, vitamin D supplementation (p=0.07), season (p=0.10) and eGFR were correlated with log PTH values in the patients with CKD.

CONCLUSION

Exposure to sunshine and an active lifestyle were correlated with higher 25-OH-vitamin D levels in older adults without CKD. The PTH level in patients with CKD may be influenced by the season.

Authors+Show Affiliations

Institute de recherché société et sante, Université Catholique de Louvain, Brussels, Belgium. gijs.vanpottelbergh@med.kuleuven.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23364486

Citation

Van Pottelbergh, G, et al. "The Influence of Renal Function On Vitamin D Metabolism in the Very Elderly." The Journal of Nutrition, Health & Aging, vol. 17, no. 2, 2013, pp. 107-11.
Van Pottelbergh G, Matheï C, Vaes B, et al. The influence of renal function on vitamin D metabolism in the very elderly. J Nutr Health Aging. 2013;17(2):107-11.
Van Pottelbergh, G., Matheï, C., Vaes, B., Adriaensen, W., Gruson, D., & Degryse, J. M. (2013). The influence of renal function on vitamin D metabolism in the very elderly. The Journal of Nutrition, Health & Aging, 17(2), 107-11. https://doi.org/10.1007/s12603-012-0094-0
Van Pottelbergh G, et al. The Influence of Renal Function On Vitamin D Metabolism in the Very Elderly. J Nutr Health Aging. 2013;17(2):107-11. PubMed PMID: 23364486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of renal function on vitamin D metabolism in the very elderly. AU - Van Pottelbergh,G, AU - Matheï,C, AU - Vaes,B, AU - Adriaensen,W, AU - Gruson,D, AU - Degryse,J M, PY - 2013/2/1/entrez PY - 2013/2/1/pubmed PY - 2013/7/16/medline SP - 107 EP - 11 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 17 IS - 2 N2 - OBJECTIVES: Hypovitaminosis D and chronic kidney disease (CKD) are highly prevalent in older adults. The factors correlating with 25-OH-vitamin D and PTH levels were analyzed in older adults with and without CKD. DESIGN: We performed a cross-sectional analysis embedded within the BELFRAIL study. SETTING: A population-based prospective cohort study of the very elderly in Belgium. PARTICIPANTS: 325 participants, all aged 80 or older. MEASURMENTS: Time of year and LAPAQ score were used as proxies for sunshine exposure. Vitamin D3 supplementation, gender, institutionalisation, age, level of education, and serum calcium and phosphorus level were examined as possible confounders in the analyses. RESULTS: There was no correlation between the presence of CKD and low 25-OH-vitamin D levels, but there was a significant (p<0.01) correlation between CKD and high PTH levels. Among the participants with a normal eGFR, the LAPACQ score, vitamin D supplementation, season, log PTH value and eGFR were correlated with log 25-OH-vitamin D levels. Among the participants with CKD, only vitamin D supplementation, log PTH levels and serum calcium levels were correlated with log 25-OH-vitamin D levels. Gender, log 25-OH-vitamin D values, serum calcium and phosphorus levels and eGFR were correlated with log PTH values in the patients with normal eGFR. Log 25-OH-vitamin D values, serum phosphorus levels, vitamin D supplementation (p=0.07), season (p=0.10) and eGFR were correlated with log PTH values in the patients with CKD. CONCLUSION: Exposure to sunshine and an active lifestyle were correlated with higher 25-OH-vitamin D levels in older adults without CKD. The PTH level in patients with CKD may be influenced by the season. SN - 1760-4788 UR - https://www.unboundmedicine.com/medline/citation/23364486/The_influence_of_renal_function_on_vitamin_D_metabolism_in_the_very_elderly_ L2 - https://doi.org/10.1007/s12603-012-0094-0 DB - PRIME DP - Unbound Medicine ER -