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High-resolution CT scan findings in familial interstitial pneumonia do not conform to those of idiopathic interstitial pneumonia.
Chest. 2012 Dec; 142(6):1577-1583.Chest

Abstract

BACKGROUND

The aim of this study was to describe the high-resolution CT (HRCT) scan features that characterize familial interstitial pneumonia (FIP).

METHODS

FIP was defined by the presence of two or more cases of probable or definite idiopathic interstitial pneumonia (IIP) in individuals related within three degrees. The cases were collected consecutively from three centers. We identified 371 individuals with potential FIP from 289 families, including 340 individuals who had HRCT scans. Two chest radiologists independently reviewed the HRCT scans, scoring the extent and distribution of HRCT scan findings, and assessed the overall radiologic diagnosis.

RESULTS

HRCT scan abnormalities suggestive of IIP were present in 85% (289 of 340 subjects). The most frequent findings were reticular pattern (n = 238, 82%) and ground-glass opacity (GGO) associated with reticular abnormality (n = 231, 80%). Other changes included GGO in 116 (40%), honeycombing in 92 (32%), and micronodules in 65 (22%). In the 289 cases with evidence of IIP, the findings were diffusely distributed in the craniocaudal plane in 186 (64%), and the lower lung zones were predominantly involved in 89 (31%). In the axial plane, 194 (67%) had a subpleural distribution; 88 (30%) were diffuse. The imaging pattern was classified as definite or probable usual interstitial pneumonia (UIP) in only 62 subjects (22%) and definite or probable nonspecific interstitial pneumonia (NSIP) in 35 subjects (12%). In 160 subjects (55%), the imaging findings did not conform to previously described UIP or NSIP patterns.

CONCLUSIONS

Reticulation and a mixed GGO/reticular pattern are the most common HRCT scan findings in FIP. The parenchymal abnormalities are most often diffuse in the craniocaudal dimension and have a predominantly peripheral distribution in the axial dimension. Although a radiologic UIP pattern is not uncommon, most cases do not conform to typical UIP or NSIP patterns.

Authors+Show Affiliations

Division of Radiology, National Jewish Health and University of Colorado, Denver, CO.Division of Radiology, National Jewish Health and University of Colorado, Denver, CO.Department of Medicine, Duke University Medical Center, Durham, NC.Department of Medicine, National Jewish Health and University of Colorado, Denver, CO.Department of Medicine, National Jewish Health and University of Colorado, Denver, CO.Division of Pulmonary, Vanderbilt University School of Medicine, Nashville, TN.Department of Medicine, National Jewish Health and University of Colorado, Denver, CO.Department of Medicine, National Jewish Health and University of Colorado, Denver, CO.Division of Radiology, National Jewish Health and University of Colorado, Denver, CO. Electronic address: lynchd@njhealth.org.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23364926

Citation

Lee, Ho Yun, et al. "High-resolution CT Scan Findings in Familial Interstitial Pneumonia Do Not Conform to Those of Idiopathic Interstitial Pneumonia." Chest, vol. 142, no. 6, 2012, pp. 1577-1583.
Lee HY, Seo JB, Steele MP, et al. High-resolution CT scan findings in familial interstitial pneumonia do not conform to those of idiopathic interstitial pneumonia. Chest. 2012;142(6):1577-1583.
Lee, H. Y., Seo, J. B., Steele, M. P., Schwarz, M. I., Brown, K. K., Loyd, J. E., Talbert, J. L., Schwartz, D. A., & Lynch, D. A. (2012). High-resolution CT scan findings in familial interstitial pneumonia do not conform to those of idiopathic interstitial pneumonia. Chest, 142(6), 1577-1583. https://doi.org/10.1378/chest.11-2812
Lee HY, et al. High-resolution CT Scan Findings in Familial Interstitial Pneumonia Do Not Conform to Those of Idiopathic Interstitial Pneumonia. Chest. 2012;142(6):1577-1583. PubMed PMID: 23364926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-resolution CT scan findings in familial interstitial pneumonia do not conform to those of idiopathic interstitial pneumonia. AU - Lee,Ho Yun, AU - Seo,Joon Beom, AU - Steele,Mark P, AU - Schwarz,Marvin I, AU - Brown,Kevin K, AU - Loyd,James E, AU - Talbert,Janet L, AU - Schwartz,David A, AU - Lynch,David A, PY - 2013/2/1/entrez PY - 2013/2/1/pubmed PY - 2013/4/4/medline SP - 1577 EP - 1583 JF - Chest JO - Chest VL - 142 IS - 6 N2 - BACKGROUND: The aim of this study was to describe the high-resolution CT (HRCT) scan features that characterize familial interstitial pneumonia (FIP). METHODS: FIP was defined by the presence of two or more cases of probable or definite idiopathic interstitial pneumonia (IIP) in individuals related within three degrees. The cases were collected consecutively from three centers. We identified 371 individuals with potential FIP from 289 families, including 340 individuals who had HRCT scans. Two chest radiologists independently reviewed the HRCT scans, scoring the extent and distribution of HRCT scan findings, and assessed the overall radiologic diagnosis. RESULTS: HRCT scan abnormalities suggestive of IIP were present in 85% (289 of 340 subjects). The most frequent findings were reticular pattern (n = 238, 82%) and ground-glass opacity (GGO) associated with reticular abnormality (n = 231, 80%). Other changes included GGO in 116 (40%), honeycombing in 92 (32%), and micronodules in 65 (22%). In the 289 cases with evidence of IIP, the findings were diffusely distributed in the craniocaudal plane in 186 (64%), and the lower lung zones were predominantly involved in 89 (31%). In the axial plane, 194 (67%) had a subpleural distribution; 88 (30%) were diffuse. The imaging pattern was classified as definite or probable usual interstitial pneumonia (UIP) in only 62 subjects (22%) and definite or probable nonspecific interstitial pneumonia (NSIP) in 35 subjects (12%). In 160 subjects (55%), the imaging findings did not conform to previously described UIP or NSIP patterns. CONCLUSIONS: Reticulation and a mixed GGO/reticular pattern are the most common HRCT scan findings in FIP. The parenchymal abnormalities are most often diffuse in the craniocaudal dimension and have a predominantly peripheral distribution in the axial dimension. Although a radiologic UIP pattern is not uncommon, most cases do not conform to typical UIP or NSIP patterns. SN - 1931-3543 UR - https://www.unboundmedicine.com/medline/citation/23364926/High_resolution_CT_scan_findings_in_familial_interstitial_pneumonia_do_not_conform_to_those_of_idiopathic_interstitial_pneumonia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(12)60693-X DB - PRIME DP - Unbound Medicine ER -