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Neuropsychiatric symptoms in Nigerian patients with Parkinson's disease.
Acta Neurol Scand. 2013 Jul; 128(1):9-16.AN

Abstract

BACKGROUND

Neuropsychiatric symptoms are common in Parkinson's disease and may precede onset of motor symptoms. They are also known to increase caregiver's burden.

OBJECTIVE

The aim of this study was to assess neuropsychiatric symptoms in a cohort of Nigerian patients with idiopathic Parkinson's disease and compare with systemic hypertension.

METHOD

Fifty patients with idiopathic Parkinson's disease were compared with fifty demographically matched controls with systemic hypertension. Diagnosis of Parkinson's disease was based on the United Kingdom Parkinson Disease Society (UKPDS) Brain Bank Clinical diagnostic Criteria. Diagnosis of hypertension was based on recorded blood pressure of ≥140/90 mmHg on two different occasions. The Neuropsychiatric Inventory (NPI) was applied to caregivers of both patients and controls.

RESULTS

There were significant differences in frequency of neuropsychiatric symptoms in patients and controls (P < 0.05). Significant differences were found in mean distress scores for some neuropsychiatric symptoms and the total mean distress score. In all cases, patients with Parkinson's disease had higher scores when compared with controls. Severity of motor symptoms, as measured by the UKPDS, correlated with total NPI severity scores (P = 0.000).

CONCLUSION

Neuropsychiatric symptoms occur more frequently in Parkinson's disease than matched controls, and the presence of these symptoms is associated with caregivers' distress. There is a need for early and adequate treatment for motor and behavioural symptoms of Parkinson's disease.

Authors+Show Affiliations

Department of Psychiatry, University College Hospital, Ibadan, Nigeria.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23368950

Citation

Ojagbemi, A A., et al. "Neuropsychiatric Symptoms in Nigerian Patients With Parkinson's Disease." Acta Neurologica Scandinavica, vol. 128, no. 1, 2013, pp. 9-16.
Ojagbemi AA, Akinyemi RO, Baiyewu O. Neuropsychiatric symptoms in Nigerian patients with Parkinson's disease. Acta Neurol Scand. 2013;128(1):9-16.
Ojagbemi, A. A., Akinyemi, R. O., & Baiyewu, O. (2013). Neuropsychiatric symptoms in Nigerian patients with Parkinson's disease. Acta Neurologica Scandinavica, 128(1), 9-16. https://doi.org/10.1111/ane.12062
Ojagbemi AA, Akinyemi RO, Baiyewu O. Neuropsychiatric Symptoms in Nigerian Patients With Parkinson's Disease. Acta Neurol Scand. 2013;128(1):9-16. PubMed PMID: 23368950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropsychiatric symptoms in Nigerian patients with Parkinson's disease. AU - Ojagbemi,A A, AU - Akinyemi,R O, AU - Baiyewu,O, Y1 - 2013/01/31/ PY - 2012/10/31/accepted PY - 2013/2/2/entrez PY - 2013/2/2/pubmed PY - 2013/11/1/medline SP - 9 EP - 16 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 128 IS - 1 N2 - BACKGROUND: Neuropsychiatric symptoms are common in Parkinson's disease and may precede onset of motor symptoms. They are also known to increase caregiver's burden. OBJECTIVE: The aim of this study was to assess neuropsychiatric symptoms in a cohort of Nigerian patients with idiopathic Parkinson's disease and compare with systemic hypertension. METHOD: Fifty patients with idiopathic Parkinson's disease were compared with fifty demographically matched controls with systemic hypertension. Diagnosis of Parkinson's disease was based on the United Kingdom Parkinson Disease Society (UKPDS) Brain Bank Clinical diagnostic Criteria. Diagnosis of hypertension was based on recorded blood pressure of ≥140/90 mmHg on two different occasions. The Neuropsychiatric Inventory (NPI) was applied to caregivers of both patients and controls. RESULTS: There were significant differences in frequency of neuropsychiatric symptoms in patients and controls (P < 0.05). Significant differences were found in mean distress scores for some neuropsychiatric symptoms and the total mean distress score. In all cases, patients with Parkinson's disease had higher scores when compared with controls. Severity of motor symptoms, as measured by the UKPDS, correlated with total NPI severity scores (P = 0.000). CONCLUSION: Neuropsychiatric symptoms occur more frequently in Parkinson's disease than matched controls, and the presence of these symptoms is associated with caregivers' distress. There is a need for early and adequate treatment for motor and behavioural symptoms of Parkinson's disease. SN - 1600-0404 UR - https://www.unboundmedicine.com/medline/citation/23368950/Neuropsychiatric_symptoms_in_Nigerian_patients_with_Parkinson's_disease_ L2 - https://doi.org/10.1111/ane.12062 DB - PRIME DP - Unbound Medicine ER -