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Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporter.
Psychopharmacology (Berl). 2013 Jun; 227(3):493-9.P

Abstract

RATIONALE

Psychoactive "bath salts" represent a relatively new drug of abuse combination that was placed in Schedule I in October 2011. Two common ingredients of bath salts include the cathinone analogs: mephedrone and methylenedioxypyrovalerone (MDPV). The mechanism of action of these synthetic cathinone analogs has not been well investigated.

MATERIALS AND METHODS

Because cathinone and methcathinone are known to act as releasing agents at the human dopamine transporter (hDAT), mephedrone and MDPV were investigated at hDAT expressed in Xenopus oocytes.

RESULTS

Whereas mephedrone was found to have the signature of a dopamine-releasing agent similar to methamphetamine or methcathinone, MDPV behaved as a cocaine-like reuptake inhibitor of dopamine.

CONCLUSIONS

Mephedrone and MDPV produce opposite electrophysiological signatures through hDAT expressed in oocytes. Implications are that the combination (as found in bath salts) might produce effects similar to a combination of methamphetamine and cocaine.

Authors+Show Affiliations

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23371489

Citation

Cameron, Krasnodara, et al. "Mephedrone and Methylenedioxypyrovalerone (MDPV), Major Constituents of "bath Salts," Produce Opposite Effects at the Human Dopamine Transporter." Psychopharmacology, vol. 227, no. 3, 2013, pp. 493-9.
Cameron K, Kolanos R, Vekariya R, et al. Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporter. Psychopharmacology (Berl). 2013;227(3):493-9.
Cameron, K., Kolanos, R., Vekariya, R., Verkariya, R., De Felice, L., & Glennon, R. A. (2013). Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporter. Psychopharmacology, 227(3), 493-9. https://doi.org/10.1007/s00213-013-2967-2
Cameron K, et al. Mephedrone and Methylenedioxypyrovalerone (MDPV), Major Constituents of "bath Salts," Produce Opposite Effects at the Human Dopamine Transporter. Psychopharmacology (Berl). 2013;227(3):493-9. PubMed PMID: 23371489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporter. AU - Cameron,Krasnodara, AU - Kolanos,Renata, AU - Vekariya,Rakesh, AU - Verkariya,Rakesh, AU - De Felice,Louis, AU - Glennon,Richard A, Y1 - 2013/01/31/ PY - 2012/06/06/received PY - 2013/01/04/accepted PY - 2013/2/2/entrez PY - 2013/2/2/pubmed PY - 2013/12/18/medline SP - 493 EP - 9 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 227 IS - 3 N2 - RATIONALE: Psychoactive "bath salts" represent a relatively new drug of abuse combination that was placed in Schedule I in October 2011. Two common ingredients of bath salts include the cathinone analogs: mephedrone and methylenedioxypyrovalerone (MDPV). The mechanism of action of these synthetic cathinone analogs has not been well investigated. MATERIALS AND METHODS: Because cathinone and methcathinone are known to act as releasing agents at the human dopamine transporter (hDAT), mephedrone and MDPV were investigated at hDAT expressed in Xenopus oocytes. RESULTS: Whereas mephedrone was found to have the signature of a dopamine-releasing agent similar to methamphetamine or methcathinone, MDPV behaved as a cocaine-like reuptake inhibitor of dopamine. CONCLUSIONS: Mephedrone and MDPV produce opposite electrophysiological signatures through hDAT expressed in oocytes. Implications are that the combination (as found in bath salts) might produce effects similar to a combination of methamphetamine and cocaine. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/23371489/Mephedrone_and_methylenedioxypyrovalerone__MDPV__major_constituents_of_"bath_salts"_produce_opposite_effects_at_the_human_dopamine_transporter_ L2 - https://dx.doi.org/10.1007/s00213-013-2967-2 DB - PRIME DP - Unbound Medicine ER -