Citation
Cameron, Krasnodara, et al. "Mephedrone and Methylenedioxypyrovalerone (MDPV), Major Constituents of "bath Salts," Produce Opposite Effects at the Human Dopamine Transporter." Psychopharmacology, vol. 227, no. 3, 2013, pp. 493-9.
Cameron K, Kolanos R, Vekariya R, et al. Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporter. Psychopharmacology (Berl). 2013;227(3):493-9.
Cameron, K., Kolanos, R., Vekariya, R., Verkariya, R., De Felice, L., & Glennon, R. A. (2013). Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporter. Psychopharmacology, 227(3), 493-9. https://doi.org/10.1007/s00213-013-2967-2
Cameron K, et al. Mephedrone and Methylenedioxypyrovalerone (MDPV), Major Constituents of "bath Salts," Produce Opposite Effects at the Human Dopamine Transporter. Psychopharmacology (Berl). 2013;227(3):493-9. PubMed PMID: 23371489.
TY - JOUR
T1 - Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporter.
AU - Cameron,Krasnodara,
AU - Kolanos,Renata,
AU - Vekariya,Rakesh,
AU - Verkariya,Rakesh,
AU - De Felice,Louis,
AU - Glennon,Richard A,
Y1 - 2013/01/31/
PY - 2012/06/06/received
PY - 2013/01/04/accepted
PY - 2013/2/2/entrez
PY - 2013/2/2/pubmed
PY - 2013/12/18/medline
SP - 493
EP - 9
JF - Psychopharmacology
JO - Psychopharmacology (Berl)
VL - 227
IS - 3
N2 - RATIONALE: Psychoactive "bath salts" represent a relatively new drug of abuse combination that was placed in Schedule I in October 2011. Two common ingredients of bath salts include the cathinone analogs: mephedrone and methylenedioxypyrovalerone (MDPV). The mechanism of action of these synthetic cathinone analogs has not been well investigated. MATERIALS AND METHODS: Because cathinone and methcathinone are known to act as releasing agents at the human dopamine transporter (hDAT), mephedrone and MDPV were investigated at hDAT expressed in Xenopus oocytes. RESULTS: Whereas mephedrone was found to have the signature of a dopamine-releasing agent similar to methamphetamine or methcathinone, MDPV behaved as a cocaine-like reuptake inhibitor of dopamine. CONCLUSIONS: Mephedrone and MDPV produce opposite electrophysiological signatures through hDAT expressed in oocytes. Implications are that the combination (as found in bath salts) might produce effects similar to a combination of methamphetamine and cocaine.
SN - 1432-2072
UR - https://www.unboundmedicine.com/medline/citation/23371489/Mephedrone_and_methylenedioxypyrovalerone__MDPV__major_constituents_of_"bath_salts"_produce_opposite_effects_at_the_human_dopamine_transporter_
L2 - https://dx.doi.org/10.1007/s00213-013-2967-2
DB - PRIME
DP - Unbound Medicine
ER -