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Effect of propofol versus sodium thiopental on electroconvulsive therapy in major depressive disorder: a randomized double-blind controlled clinical trial.
J ECT. 2013 Mar; 29(1):37-40.JE

Abstract

OBJECTIVES

To compare propofol and sodium thiopental as anesthetic agents for electroconvulsive therapy (ECT) in major depression with respect to clinical effect.

METHODS

Participants were composed of 96 patients with depression who were administered either propofol or sodium thiopental as an anesthetic agent for bilateral ECT. The Hamilton Depression Rating Scale was administered at baseline and after 6 treatments. Algorithm-based charge dosing was used.

RESULTS

There was a statistically significant difference between the groups regarding postintervention Hamilton Depression Rating Scale score. The preintervention mean (SD) scores in the propofol group and the sodium thiopental group were 37.3 (2.2) and 36.7 (1.2), respectively. The postintervention mean (SD) scores in the propofol group and the sodium thiopental group were 10.7 (1.8) and 13.4 (3.3), respectively. No correlation was found between clinical response and age, weight, and body mass index. There was no association between the groups' seizure time and duration of recovery.

CONCLUSIONS

In conclusion, propofol may improve major depressive disorder more than sodium thiopental in patients who are receiving ECT.

Authors+Show Affiliations

Department of Anesthesiology and Reanimation, Gülhane Military Medical Academy, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23377746

Citation

Purtuloğlu, Tark, et al. "Effect of Propofol Versus Sodium Thiopental On Electroconvulsive Therapy in Major Depressive Disorder: a Randomized Double-blind Controlled Clinical Trial." The Journal of ECT, vol. 29, no. 1, 2013, pp. 37-40.
Purtuloğlu T, Özdemir B, Erdem M, et al. Effect of propofol versus sodium thiopental on electroconvulsive therapy in major depressive disorder: a randomized double-blind controlled clinical trial. J ECT. 2013;29(1):37-40.
Purtuloğlu, T., Özdemir, B., Erdem, M., Deniz, S., Balkç, A., Ünlü, G., & Öznur, T. (2013). Effect of propofol versus sodium thiopental on electroconvulsive therapy in major depressive disorder: a randomized double-blind controlled clinical trial. The Journal of ECT, 29(1), 37-40. https://doi.org/10.1097/YCT.0b013e318271200b
Purtuloğlu T, et al. Effect of Propofol Versus Sodium Thiopental On Electroconvulsive Therapy in Major Depressive Disorder: a Randomized Double-blind Controlled Clinical Trial. J ECT. 2013;29(1):37-40. PubMed PMID: 23377746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of propofol versus sodium thiopental on electroconvulsive therapy in major depressive disorder: a randomized double-blind controlled clinical trial. AU - Purtuloğlu,Tark, AU - Özdemir,Barbaros, AU - Erdem,Murat, AU - Deniz,Süleyman, AU - Balkç,Adem, AU - Ünlü,Gazi, AU - Öznur,Taner, PY - 2013/2/5/entrez PY - 2013/2/5/pubmed PY - 2013/8/7/medline SP - 37 EP - 40 JF - The journal of ECT JO - J ECT VL - 29 IS - 1 N2 - OBJECTIVES: To compare propofol and sodium thiopental as anesthetic agents for electroconvulsive therapy (ECT) in major depression with respect to clinical effect. METHODS: Participants were composed of 96 patients with depression who were administered either propofol or sodium thiopental as an anesthetic agent for bilateral ECT. The Hamilton Depression Rating Scale was administered at baseline and after 6 treatments. Algorithm-based charge dosing was used. RESULTS: There was a statistically significant difference between the groups regarding postintervention Hamilton Depression Rating Scale score. The preintervention mean (SD) scores in the propofol group and the sodium thiopental group were 37.3 (2.2) and 36.7 (1.2), respectively. The postintervention mean (SD) scores in the propofol group and the sodium thiopental group were 10.7 (1.8) and 13.4 (3.3), respectively. No correlation was found between clinical response and age, weight, and body mass index. There was no association between the groups' seizure time and duration of recovery. CONCLUSIONS: In conclusion, propofol may improve major depressive disorder more than sodium thiopental in patients who are receiving ECT. SN - 1533-4112 UR - https://www.unboundmedicine.com/medline/citation/23377746/Effect_of_propofol_versus_sodium_thiopental_on_electroconvulsive_therapy_in_major_depressive_disorder:_a_randomized_double_blind_controlled_clinical_trial_ L2 - https://doi.org/10.1097/YCT.0b013e318271200b DB - PRIME DP - Unbound Medicine ER -