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Indolent course of cutaneous gamma-delta T-cell lymphoma.
J Cutan Pathol 2013; 40(10):896-902JC

Abstract

Cutaneous gamma-delta T-cell lymphoma (γδTCL) is a rare malignancy that typically displays an aggressive clinical course. We present an unusual case of a 57-year-old woman with a 3-year history of lower extremity nodules. Histopathologic, immunophenotypic and molecular genetic studies revealed a clonal, predominantly pannicular gamma-delta T-cell infiltrate, leading to a diagnosis of cutaneous γδTCL. The clinical course was characterized by rapid improvement within months of starting systemic corticosteroids, with relapse in ulcerations but no new lesions more than 3 years after onset of disease. Our case and seven previously reported patients with indolent and relatively localized cutaneous γδTCL provide evidence that not all cases of this entity carry a poor prognosis. This indolent subset adds complexity to treatment of cutaneous γδTCL.

Authors+Show Affiliations

College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23379625

Citation

Endly, Dawnielle C., et al. "Indolent Course of Cutaneous Gamma-delta T-cell Lymphoma." Journal of Cutaneous Pathology, vol. 40, no. 10, 2013, pp. 896-902.
Endly DC, Weenig RH, Peters MS, et al. Indolent course of cutaneous gamma-delta T-cell lymphoma. J Cutan Pathol. 2013;40(10):896-902.
Endly, D. C., Weenig, R. H., Peters, M. S., Viswanatha, D. S., & Comfere, N. I. (2013). Indolent course of cutaneous gamma-delta T-cell lymphoma. Journal of Cutaneous Pathology, 40(10), pp. 896-902. doi:10.1111/cup.12091.
Endly DC, et al. Indolent Course of Cutaneous Gamma-delta T-cell Lymphoma. J Cutan Pathol. 2013;40(10):896-902. PubMed PMID: 23379625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indolent course of cutaneous gamma-delta T-cell lymphoma. AU - Endly,Dawnielle C, AU - Weenig,Roger H, AU - Peters,Margot S, AU - Viswanatha,David S, AU - Comfere,Nneka I, Y1 - 2013/02/04/ PY - 2012/09/10/received PY - 2012/12/03/revised PY - 2012/12/16/accepted PY - 2013/2/6/entrez PY - 2013/2/6/pubmed PY - 2014/4/26/medline KW - connective tissue disease panniculitis KW - gamma-delta T-cell lymphoma KW - panniculitic lymphoma SP - 896 EP - 902 JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. VL - 40 IS - 10 N2 - Cutaneous gamma-delta T-cell lymphoma (γδTCL) is a rare malignancy that typically displays an aggressive clinical course. We present an unusual case of a 57-year-old woman with a 3-year history of lower extremity nodules. Histopathologic, immunophenotypic and molecular genetic studies revealed a clonal, predominantly pannicular gamma-delta T-cell infiltrate, leading to a diagnosis of cutaneous γδTCL. The clinical course was characterized by rapid improvement within months of starting systemic corticosteroids, with relapse in ulcerations but no new lesions more than 3 years after onset of disease. Our case and seven previously reported patients with indolent and relatively localized cutaneous γδTCL provide evidence that not all cases of this entity carry a poor prognosis. This indolent subset adds complexity to treatment of cutaneous γδTCL. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/23379625/Indolent_course_of_cutaneous_gamma_delta_T_cell_lymphoma_ L2 - https://doi.org/10.1111/cup.12091 DB - PRIME DP - Unbound Medicine ER -