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Does correction of metabolic acidosis slow chronic kidney disease progression?
Curr Opin Nephrol Hypertens. 2013 Mar; 22(2):193-7.CO

Abstract

PURPOSE OF REVIEW

Most patients with chronic kidney disease (CKD) have progressive decline in glomerular filtration rate (GFR), despite current treatment practices. Recent studies support that dietary acid reduction with oral sodium based alkali or base-inducing food types add kidney protection to that provided by current kidney-protective interventions. Related studies also support that correction of metabolic acidosis with dietary acid reduction slows CKD progression. We reviewed these recent studies that show improvement in CKD parameters and slower CKD progression in response to improvement of CKD-associated metabolic acidosis with these interventions.

RECENT FINDINGS

Animal as well as human models of CKD show that alkali treatment ameliorates indices of kidney injury and also might slow GFR decline in patients with or without metabolic acidosis. These benefits have been similar with oral sodium-based alkali and base-inducing fruits and vegetables, supporting dietary acid reduction as an effective adjunct to conventional kidney-protective interventions.

SUMMARY

Recent studies suggest that metabolic acidosis mediates nephropathy progression, and its treatment with the comparatively inexpensive and well tolerated intervention of dietary acid reduction holds promise to be an additional kidney-protective strategy in CKD management.

Authors+Show Affiliations

Texas A&M College of Medicine, Department of Internal Medicine, Temple, Texas, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23380803

Citation

Goraya, Nimrit, and Donald E. Wesson. "Does Correction of Metabolic Acidosis Slow Chronic Kidney Disease Progression?" Current Opinion in Nephrology and Hypertension, vol. 22, no. 2, 2013, pp. 193-7.
Goraya N, Wesson DE. Does correction of metabolic acidosis slow chronic kidney disease progression? Curr Opin Nephrol Hypertens. 2013;22(2):193-7.
Goraya, N., & Wesson, D. E. (2013). Does correction of metabolic acidosis slow chronic kidney disease progression? Current Opinion in Nephrology and Hypertension, 22(2), 193-7. https://doi.org/10.1097/MNH.0b013e32835dcbbe
Goraya N, Wesson DE. Does Correction of Metabolic Acidosis Slow Chronic Kidney Disease Progression. Curr Opin Nephrol Hypertens. 2013;22(2):193-7. PubMed PMID: 23380803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does correction of metabolic acidosis slow chronic kidney disease progression? AU - Goraya,Nimrit, AU - Wesson,Donald E, PY - 2013/2/6/entrez PY - 2013/2/6/pubmed PY - 2013/7/28/medline SP - 193 EP - 7 JF - Current opinion in nephrology and hypertension JO - Curr Opin Nephrol Hypertens VL - 22 IS - 2 N2 - PURPOSE OF REVIEW: Most patients with chronic kidney disease (CKD) have progressive decline in glomerular filtration rate (GFR), despite current treatment practices. Recent studies support that dietary acid reduction with oral sodium based alkali or base-inducing food types add kidney protection to that provided by current kidney-protective interventions. Related studies also support that correction of metabolic acidosis with dietary acid reduction slows CKD progression. We reviewed these recent studies that show improvement in CKD parameters and slower CKD progression in response to improvement of CKD-associated metabolic acidosis with these interventions. RECENT FINDINGS: Animal as well as human models of CKD show that alkali treatment ameliorates indices of kidney injury and also might slow GFR decline in patients with or without metabolic acidosis. These benefits have been similar with oral sodium-based alkali and base-inducing fruits and vegetables, supporting dietary acid reduction as an effective adjunct to conventional kidney-protective interventions. SUMMARY: Recent studies suggest that metabolic acidosis mediates nephropathy progression, and its treatment with the comparatively inexpensive and well tolerated intervention of dietary acid reduction holds promise to be an additional kidney-protective strategy in CKD management. SN - 1473-6543 UR - https://www.unboundmedicine.com/medline/citation/23380803/Does_correction_of_metabolic_acidosis_slow_chronic_kidney_disease_progression L2 - https://doi.org/10.1097/MNH.0b013e32835dcbbe DB - PRIME DP - Unbound Medicine ER -