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Proteomic biomarkers of preterm birth risk in women with polycystic ovary syndrome (PCOS): a systematic review and biomarker database integration.
PLoS One 2013; 8(1):e53801Plos

Abstract

BACKGROUND

Preterm Birth (PTB) is a major cause of neonatal mortality and morbidity. Women with Polycystic Ovary Syndrome (PCOS) are at high risk of PTB. There is a need for research studies to investigate the mechanisms linking PCOS and PTB, to facilitate screening, and develop novel preventative strategies.

OBJECTIVE

To list all the proteomic biomarkers of PTB and integrate this list with the PCOS biomarker database to identify commonly expressed biomarkers of the two conditions.

SEARCH STRATEGY

A systematic review of PTB biomarkers and update of PCOS biomarker database. All eligible published studies on proteomic biomarkers for PTB and PCOS identified through various databases were evaluated.

SELECTION CRITERIA

For the identification of the relevant studies, the following search terms were used: "proteomics", "proteomic", "preterm birth", "preterm labour", "proteomic biomarker" and "polycystic ovary syndrome". This search was restricted to humans only

DATA COLLECTION AND ANALYSIS

A database on proteomic biomarkers for PTB was created while an already existing PCOS biomarker database was updated. The two databases were integrated and biomarkers that were co-expressed in both women with PCOS and PTB were identified and investigated.

RESULTS

A panel of six proteomic biomarkers was similarly differentially expressed in women with PTB and women with PCOS compared to their respective controls (normal age-matched women in the case of PCOS studies and women with term pregnancy in the case of PTB studies). These biomarkers include Pyruvate kinase M1/M2, Vimentin, Fructose bisphosphonate aldolase A, Heat shock protein beta-1, Peroxiredoxin-1 and Transferrin.

CONCLUSIONS

These proteomic biomarkers (Pyruvate kinase M1/M2, Vimentin, Fructose bisphosphonate aldolase A, Heat shock protein beta-1, Peroxiredoxin-1 and Transferrin) can be potentially used to better understand the pathophysiological mechanisms linking PCOS and PTB. This would help to identify subgroups of women with PCOS at risk of PTB and hence the potential of developing preventative strategies.

Authors+Show Affiliations

Division of Human Development, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom. ngalazis@gmail.com

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

23382852

Citation

Galazis, Nicolas, et al. "Proteomic Biomarkers of Preterm Birth Risk in Women With Polycystic Ovary Syndrome (PCOS): a Systematic Review and Biomarker Database Integration." PloS One, vol. 8, no. 1, 2013, pp. e53801.
Galazis N, Docheva N, Nicolaides KH, et al. Proteomic biomarkers of preterm birth risk in women with polycystic ovary syndrome (PCOS): a systematic review and biomarker database integration. PLoS ONE. 2013;8(1):e53801.
Galazis, N., Docheva, N., Nicolaides, K. H., & Atiomo, W. (2013). Proteomic biomarkers of preterm birth risk in women with polycystic ovary syndrome (PCOS): a systematic review and biomarker database integration. PloS One, 8(1), pp. e53801. doi:10.1371/journal.pone.0053801.
Galazis N, et al. Proteomic Biomarkers of Preterm Birth Risk in Women With Polycystic Ovary Syndrome (PCOS): a Systematic Review and Biomarker Database Integration. PLoS ONE. 2013;8(1):e53801. PubMed PMID: 23382852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proteomic biomarkers of preterm birth risk in women with polycystic ovary syndrome (PCOS): a systematic review and biomarker database integration. AU - Galazis,Nicolas, AU - Docheva,Nikolina, AU - Nicolaides,Kypros H, AU - Atiomo,William, Y1 - 2013/01/29/ PY - 2012/05/17/received PY - 2012/12/05/accepted PY - 2013/2/6/entrez PY - 2013/2/6/pubmed PY - 2013/9/5/medline SP - e53801 EP - e53801 JF - PloS one JO - PLoS ONE VL - 8 IS - 1 N2 - BACKGROUND: Preterm Birth (PTB) is a major cause of neonatal mortality and morbidity. Women with Polycystic Ovary Syndrome (PCOS) are at high risk of PTB. There is a need for research studies to investigate the mechanisms linking PCOS and PTB, to facilitate screening, and develop novel preventative strategies. OBJECTIVE: To list all the proteomic biomarkers of PTB and integrate this list with the PCOS biomarker database to identify commonly expressed biomarkers of the two conditions. SEARCH STRATEGY: A systematic review of PTB biomarkers and update of PCOS biomarker database. All eligible published studies on proteomic biomarkers for PTB and PCOS identified through various databases were evaluated. SELECTION CRITERIA: For the identification of the relevant studies, the following search terms were used: "proteomics", "proteomic", "preterm birth", "preterm labour", "proteomic biomarker" and "polycystic ovary syndrome". This search was restricted to humans only DATA COLLECTION AND ANALYSIS: A database on proteomic biomarkers for PTB was created while an already existing PCOS biomarker database was updated. The two databases were integrated and biomarkers that were co-expressed in both women with PCOS and PTB were identified and investigated. RESULTS: A panel of six proteomic biomarkers was similarly differentially expressed in women with PTB and women with PCOS compared to their respective controls (normal age-matched women in the case of PCOS studies and women with term pregnancy in the case of PTB studies). These biomarkers include Pyruvate kinase M1/M2, Vimentin, Fructose bisphosphonate aldolase A, Heat shock protein beta-1, Peroxiredoxin-1 and Transferrin. CONCLUSIONS: These proteomic biomarkers (Pyruvate kinase M1/M2, Vimentin, Fructose bisphosphonate aldolase A, Heat shock protein beta-1, Peroxiredoxin-1 and Transferrin) can be potentially used to better understand the pathophysiological mechanisms linking PCOS and PTB. This would help to identify subgroups of women with PCOS at risk of PTB and hence the potential of developing preventative strategies. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23382852/Proteomic_biomarkers_of_preterm_birth_risk_in_women_with_polycystic_ovary_syndrome__PCOS_:_a_systematic_review_and_biomarker_database_integration_ L2 - http://dx.plos.org/10.1371/journal.pone.0053801 DB - PRIME DP - Unbound Medicine ER -