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The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review.

Abstract

BACKGROUND

Vitamin D deficiency is more prevalent among SLE patients than the general population. Over the past decade, many studies across the globe have been carried out to investigate the role of vitamin D in SLE from various clinical angles. Therefore, the aim of this systematic review is to summarise and evaluate the evidence from the published literature; focusing on the clinical significance of vitamin D in SLE.

METHODS

THE FOLLOWING DATABASES WERE SEARCHED: MEDLINE, Scopus, Web of Knowledge and CINAHL, using the terms "lupus", "systemic lupus erythematosus", "SLE and "vitamin D". We included only adult human studies published in the English language between 2000 and 2012.The reference lists of included studies were thoroughly reviewed in search for other relevant studies.

RESULTS

A total of 22 studies met the selection criteria. The majority of the studies were observational (95.5%) and cross sectional (90.9%). Out of the 15 studies which looked into the association between vitamin D and SLE disease activity, 10 studies (including the 3 largest studies in this series) revealed a statistically significant inverse relationship. For disease damage, on the other hand, 5 out of 6 studies failed to demonstrate any association with vitamin D levels. Cardiovascular risk factors such as insulin resistance, hypertension and hypercholesterolaemia were related to vitamin D deficiency, according to 3 of the studies.

CONCLUSION

There is convincing evidence to support the association between vitamin D levels and SLE disease activity. There is paucity of data in other clinical aspects to make firm conclusions.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia. sakthis5@hotmail.com

    Source

    PloS one 8:1 2013 pg e55275

    MeSH

    Cardiovascular Diseases
    Humans
    Lupus Erythematosus, Systemic
    MEDLINE
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    23383135

    Citation

    Sakthiswary, Rajalingham, and Azman Ali Raymond. "The Clinical Significance of Vitamin D in Systemic Lupus Erythematosus: a Systematic Review." PloS One, vol. 8, no. 1, 2013, pp. e55275.
    Sakthiswary R, Raymond AA. The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review. PLoS ONE. 2013;8(1):e55275.
    Sakthiswary, R., & Raymond, A. A. (2013). The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review. PloS One, 8(1), pp. e55275. doi:10.1371/journal.pone.0055275.
    Sakthiswary R, Raymond AA. The Clinical Significance of Vitamin D in Systemic Lupus Erythematosus: a Systematic Review. PLoS ONE. 2013;8(1):e55275. PubMed PMID: 23383135.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review. AU - Sakthiswary,Rajalingham, AU - Raymond,Azman Ali, Y1 - 2013/01/30/ PY - 2012/10/11/received PY - 2012/12/30/accepted PY - 2013/2/6/entrez PY - 2013/2/6/pubmed PY - 2013/7/23/medline SP - e55275 EP - e55275 JF - PloS one JO - PLoS ONE VL - 8 IS - 1 N2 - BACKGROUND: Vitamin D deficiency is more prevalent among SLE patients than the general population. Over the past decade, many studies across the globe have been carried out to investigate the role of vitamin D in SLE from various clinical angles. Therefore, the aim of this systematic review is to summarise and evaluate the evidence from the published literature; focusing on the clinical significance of vitamin D in SLE. METHODS: THE FOLLOWING DATABASES WERE SEARCHED: MEDLINE, Scopus, Web of Knowledge and CINAHL, using the terms "lupus", "systemic lupus erythematosus", "SLE and "vitamin D". We included only adult human studies published in the English language between 2000 and 2012.The reference lists of included studies were thoroughly reviewed in search for other relevant studies. RESULTS: A total of 22 studies met the selection criteria. The majority of the studies were observational (95.5%) and cross sectional (90.9%). Out of the 15 studies which looked into the association between vitamin D and SLE disease activity, 10 studies (including the 3 largest studies in this series) revealed a statistically significant inverse relationship. For disease damage, on the other hand, 5 out of 6 studies failed to demonstrate any association with vitamin D levels. Cardiovascular risk factors such as insulin resistance, hypertension and hypercholesterolaemia were related to vitamin D deficiency, according to 3 of the studies. CONCLUSION: There is convincing evidence to support the association between vitamin D levels and SLE disease activity. There is paucity of data in other clinical aspects to make firm conclusions. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23383135/full_citation L2 - http://dx.plos.org/10.1371/journal.pone.0055275 DB - PRIME DP - Unbound Medicine ER -