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Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome.
J Natl Cancer Inst. 2013 Feb 20; 105(4):274-9.JNCI

Abstract

BACKGROUND

Lynch syndrome is an autosomal dominantly inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Previous studies have shown that MMR gene mutation carriers are at increased risk of colorectal, endometrial, and several other cancers following an initial diagnosis of colorectal cancer. We estimated cancer risks following an endometrial cancer diagnosis for women carrying MMR gene mutations.

METHODS

We obtained data from the Colon Cancer Family Registry for a cohort of 127 women who had a diagnosis of endometrial cancer and who carried a mutation in one of four MMR genes (30 carried a mutation in MLH1, 72 in MSH2, 22 in MSH6, and 3 in PMS2). We used the Kaplan-Meier method to estimate 10- and 20-year cumulative risks for each cancer. We estimated the age-, country-, and calendar period-specific standardized incidence ratios (SIRs) for each cancer, compared with the general population.

RESULTS

Following endometrial cancer, women carrying MMR gene mutations had the following 20-year risks of other cancer cancers: colorectal cancer (48%, 95% confidence interval [CI] = 35% to 62%); cancer of the kidney, renal pelvis, or ureter (11%, 95% CI = 3% to 20%); urinary bladder cancer (9%, 95% CI = 2% to 17%); and breast cancer (11%, 95% CI = 4% to 19%). Compared with the general population, these women were at statistically significantly elevated risks of colorectal cancer (SIR = 39.9, 95% CI = 27.2 to 58.3), cancer of the kidney, renal pelvis, or ureter (SIR = 28.3, 95% CI = 11.9 to 48.6), urinary bladder cancer (SIR = 24.3, 95% CI = 8.56 to 42.9), and breast cancer (SIR = 2.51, 95% CI = 1.17 to 4.14).

CONCLUSIONS

Women with Lynch syndrome who are diagnosed with endometrial cancer have increased risks of several cancers, including breast cancer.

Authors+Show Affiliations

Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, Level 3, 207 Bouverie St, University of Melbourne, VIC 3010 Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23385444

Citation

Win, Aung Ko, et al. "Risks of Colorectal and Other Cancers After Endometrial Cancer for Women With Lynch Syndrome." Journal of the National Cancer Institute, vol. 105, no. 4, 2013, pp. 274-9.
Win AK, Lindor NM, Winship I, et al. Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome. J Natl Cancer Inst. 2013;105(4):274-9.
Win, A. K., Lindor, N. M., Winship, I., Tucker, K. M., Buchanan, D. D., Young, J. P., Rosty, C., Leggett, B., Giles, G. G., Goldblatt, J., Macrae, F. A., Parry, S., Kalady, M. F., Baron, J. A., Ahnen, D. J., Marchand, L. L., Gallinger, S., Haile, R. W., Newcomb, P. A., ... Jenkins, M. A. (2013). Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome. Journal of the National Cancer Institute, 105(4), 274-9. https://doi.org/10.1093/jnci/djs525
Win AK, et al. Risks of Colorectal and Other Cancers After Endometrial Cancer for Women With Lynch Syndrome. J Natl Cancer Inst. 2013 Feb 20;105(4):274-9. PubMed PMID: 23385444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome. AU - Win,Aung Ko, AU - Lindor,Noralane M, AU - Winship,Ingrid, AU - Tucker,Katherine M, AU - Buchanan,Daniel D, AU - Young,Joanne P, AU - Rosty,Christophe, AU - Leggett,Barbara, AU - Giles,Graham G, AU - Goldblatt,Jack, AU - Macrae,Finlay A, AU - Parry,Susan, AU - Kalady,Matthew F, AU - Baron,John A, AU - Ahnen,Dennis J, AU - Marchand,Loic Le, AU - Gallinger,Steven, AU - Haile,Robert W, AU - Newcomb,Polly A, AU - Hopper,John L, AU - Jenkins,Mark A, Y1 - 2013/02/05/ PY - 2013/2/7/entrez PY - 2013/2/7/pubmed PY - 2013/4/6/medline SP - 274 EP - 9 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 105 IS - 4 N2 - BACKGROUND: Lynch syndrome is an autosomal dominantly inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Previous studies have shown that MMR gene mutation carriers are at increased risk of colorectal, endometrial, and several other cancers following an initial diagnosis of colorectal cancer. We estimated cancer risks following an endometrial cancer diagnosis for women carrying MMR gene mutations. METHODS: We obtained data from the Colon Cancer Family Registry for a cohort of 127 women who had a diagnosis of endometrial cancer and who carried a mutation in one of four MMR genes (30 carried a mutation in MLH1, 72 in MSH2, 22 in MSH6, and 3 in PMS2). We used the Kaplan-Meier method to estimate 10- and 20-year cumulative risks for each cancer. We estimated the age-, country-, and calendar period-specific standardized incidence ratios (SIRs) for each cancer, compared with the general population. RESULTS: Following endometrial cancer, women carrying MMR gene mutations had the following 20-year risks of other cancer cancers: colorectal cancer (48%, 95% confidence interval [CI] = 35% to 62%); cancer of the kidney, renal pelvis, or ureter (11%, 95% CI = 3% to 20%); urinary bladder cancer (9%, 95% CI = 2% to 17%); and breast cancer (11%, 95% CI = 4% to 19%). Compared with the general population, these women were at statistically significantly elevated risks of colorectal cancer (SIR = 39.9, 95% CI = 27.2 to 58.3), cancer of the kidney, renal pelvis, or ureter (SIR = 28.3, 95% CI = 11.9 to 48.6), urinary bladder cancer (SIR = 24.3, 95% CI = 8.56 to 42.9), and breast cancer (SIR = 2.51, 95% CI = 1.17 to 4.14). CONCLUSIONS: Women with Lynch syndrome who are diagnosed with endometrial cancer have increased risks of several cancers, including breast cancer. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/23385444/Risks_of_colorectal_and_other_cancers_after_endometrial_cancer_for_women_with_Lynch_syndrome_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djs525 DB - PRIME DP - Unbound Medicine ER -