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Serum prolactin concentration at presentation of non-functioning pituitary macroadenomas.
J Endocrinol Invest. 2013 Jul-Aug; 36(7):508-14.JE

Abstract

OBJECTIVE

Serum PRL levels at presentation may be useful in distinguishing between disconnection hyperprolactinemia in non-secretory pituitary adenomas and prolactinomas in order to guide appropriate therapy; however, there is a debate regarding the discriminatory PRL thresholds. We aimed to examine PRL concentrations at presentation in a cohort of histologically proven non-functioning pituitary adenomas (NFPA).

DESIGN AND METHODS

Retrospective case note analysis was performed. Clinical, biochemical, histopathological and radiological data were recorded and analyzed. Complete data were available for 250 subjects with NFPA.

RESULTS

Of the study population, 44.8% were hyperprolactinemic at presentation, 55.3% of whom were female. Of those with hyperprolactinemia, 73.2% had PRL<1000 mIU/l on presentation, 24.1% had PRL between 1000 and 1999 mIU/l. Only 2.7% (no.=3 females, 1.2% whole cohort) had PRL>2000 mIU/l (94.3 ng/ml), 2 of whom were pregnant. No male subject and no subjects with an intrasellar macroadenoma had serum PRL>1000 mIU/l (47.2 ng/ml). Overall, serum PRL was not higher among 43 subjects taking medications known to raise PRL.

CONCLUSIONS

Our data support recent evidence that the serum PRL concentration is rarely >1000 mIU/l in males, or >2000 mIU/l in females, with non-functioning macroadenomas and that, once other contributing factors to the hyperprolactinemia have been excluded, a trial of dopamine agonist therapy for such lesions is indicated.

Authors+Show Affiliations

Division of Neuro-endocrinology, Beaumont Hospital and the RCSI Medical School, Beaumont Road, Dublin 9, Ireland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23385474

Citation

Behan, L A., et al. "Serum Prolactin Concentration at Presentation of Non-functioning Pituitary Macroadenomas." Journal of Endocrinological Investigation, vol. 36, no. 7, 2013, pp. 508-14.
Behan LA, O'Sullivan EP, Glynn N, et al. Serum prolactin concentration at presentation of non-functioning pituitary macroadenomas. J Endocrinol Invest. 2013;36(7):508-14.
Behan, L. A., O'Sullivan, E. P., Glynn, N., Woods, C., Crowley, R. K., Tun, T. K., Smith, D., Thompson, C. J., & Agha, A. (2013). Serum prolactin concentration at presentation of non-functioning pituitary macroadenomas. Journal of Endocrinological Investigation, 36(7), 508-14. https://doi.org/10.3275/8815
Behan LA, et al. Serum Prolactin Concentration at Presentation of Non-functioning Pituitary Macroadenomas. J Endocrinol Invest. 2013 Jul-Aug;36(7):508-14. PubMed PMID: 23385474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum prolactin concentration at presentation of non-functioning pituitary macroadenomas. AU - Behan,L A, AU - O'Sullivan,E P, AU - Glynn,N, AU - Woods,C, AU - Crowley,R K, AU - Tun,T K, AU - Smith,D, AU - Thompson,C J, AU - Agha,A, Y1 - 2013/02/04/ PY - 2013/2/7/entrez PY - 2013/2/7/pubmed PY - 2014/3/19/medline SP - 508 EP - 14 JF - Journal of endocrinological investigation JO - J Endocrinol Invest VL - 36 IS - 7 N2 - OBJECTIVE: Serum PRL levels at presentation may be useful in distinguishing between disconnection hyperprolactinemia in non-secretory pituitary adenomas and prolactinomas in order to guide appropriate therapy; however, there is a debate regarding the discriminatory PRL thresholds. We aimed to examine PRL concentrations at presentation in a cohort of histologically proven non-functioning pituitary adenomas (NFPA). DESIGN AND METHODS: Retrospective case note analysis was performed. Clinical, biochemical, histopathological and radiological data were recorded and analyzed. Complete data were available for 250 subjects with NFPA. RESULTS: Of the study population, 44.8% were hyperprolactinemic at presentation, 55.3% of whom were female. Of those with hyperprolactinemia, 73.2% had PRL<1000 mIU/l on presentation, 24.1% had PRL between 1000 and 1999 mIU/l. Only 2.7% (no.=3 females, 1.2% whole cohort) had PRL>2000 mIU/l (94.3 ng/ml), 2 of whom were pregnant. No male subject and no subjects with an intrasellar macroadenoma had serum PRL>1000 mIU/l (47.2 ng/ml). Overall, serum PRL was not higher among 43 subjects taking medications known to raise PRL. CONCLUSIONS: Our data support recent evidence that the serum PRL concentration is rarely >1000 mIU/l in males, or >2000 mIU/l in females, with non-functioning macroadenomas and that, once other contributing factors to the hyperprolactinemia have been excluded, a trial of dopamine agonist therapy for such lesions is indicated. SN - 1720-8386 UR - https://www.unboundmedicine.com/medline/citation/23385474/Serum_prolactin_concentration_at_presentation_of_non_functioning_pituitary_macroadenomas_ L2 - https://link.springer.com/article/10.3275/8815 DB - PRIME DP - Unbound Medicine ER -