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Compressed orally disintegrating tablets: excipients evolution and formulation strategies.
Expert Opin Drug Deliv. 2013 May; 10(5):651-63.EO

Abstract

INTRODUCTION

Orally disintegrating tablets (ODTs) have emerged as one of the novel solid oral dosage forms with a potential to deliver a wide range of drug candidates to both paediatric and geriatric patient populations. Of the plethora of available technologies, compression of excipients offers a cost-effective and translatable methodology for the manufacture of ODTs.

AREAS COVERED

The review is a modest endeavour from the authors to assemble literature published over the last couple of decades on formulation development of compressed ODT. It describes the main ODT excipients used since the introduction of this dosage form in the 1990s and explores the switch from cellulose-based excipients towards sugar/polyols. Furthermore, it unfolds the key properties of ODT fillers, binders and disintegrants with an emphasis on their advantages and drawbacks. The review also provides a critical assessment of the various strategies employed for performance enhancement of compressed ODT with a focus on the underlying mechanisms for fast disintegration and acceptable mechanical strength.

EXPERT OPINION

Recent increase in the total number of compression-based technologies for ODT development promises to reduce the manufacturing cost of this dosage form in the future. However, some of the developed methods may affect the stability of tablets due to susceptibility to moisture, collapse of pores or the generation of less stable polymorphs which require rigorous testing prior to commercialization.

Authors+Show Affiliations

Aston University, Aston Pharmacy School , Aston Triangle, Birmingham B4 7ET , UK. a.u.r.mohammed@aston.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23387409

Citation

Al-khattawi, Ali, and Afzal R. Mohammed. "Compressed Orally Disintegrating Tablets: Excipients Evolution and Formulation Strategies." Expert Opinion On Drug Delivery, vol. 10, no. 5, 2013, pp. 651-63.
Al-khattawi A, Mohammed AR. Compressed orally disintegrating tablets: excipients evolution and formulation strategies. Expert Opin Drug Deliv. 2013;10(5):651-63.
Al-khattawi, A., & Mohammed, A. R. (2013). Compressed orally disintegrating tablets: excipients evolution and formulation strategies. Expert Opinion On Drug Delivery, 10(5), 651-63. https://doi.org/10.1517/17425247.2013.769955
Al-khattawi A, Mohammed AR. Compressed Orally Disintegrating Tablets: Excipients Evolution and Formulation Strategies. Expert Opin Drug Deliv. 2013;10(5):651-63. PubMed PMID: 23387409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compressed orally disintegrating tablets: excipients evolution and formulation strategies. AU - Al-khattawi,Ali, AU - Mohammed,Afzal R, Y1 - 2013/02/07/ PY - 2013/2/8/entrez PY - 2013/2/8/pubmed PY - 2013/7/5/medline SP - 651 EP - 63 JF - Expert opinion on drug delivery JO - Expert Opin Drug Deliv VL - 10 IS - 5 N2 - INTRODUCTION: Orally disintegrating tablets (ODTs) have emerged as one of the novel solid oral dosage forms with a potential to deliver a wide range of drug candidates to both paediatric and geriatric patient populations. Of the plethora of available technologies, compression of excipients offers a cost-effective and translatable methodology for the manufacture of ODTs. AREAS COVERED: The review is a modest endeavour from the authors to assemble literature published over the last couple of decades on formulation development of compressed ODT. It describes the main ODT excipients used since the introduction of this dosage form in the 1990s and explores the switch from cellulose-based excipients towards sugar/polyols. Furthermore, it unfolds the key properties of ODT fillers, binders and disintegrants with an emphasis on their advantages and drawbacks. The review also provides a critical assessment of the various strategies employed for performance enhancement of compressed ODT with a focus on the underlying mechanisms for fast disintegration and acceptable mechanical strength. EXPERT OPINION: Recent increase in the total number of compression-based technologies for ODT development promises to reduce the manufacturing cost of this dosage form in the future. However, some of the developed methods may affect the stability of tablets due to susceptibility to moisture, collapse of pores or the generation of less stable polymorphs which require rigorous testing prior to commercialization. SN - 1744-7593 UR - https://www.unboundmedicine.com/medline/citation/23387409/Compressed_orally_disintegrating_tablets:_excipients_evolution_and_formulation_strategies_ L2 - http://www.tandfonline.com/doi/full/10.1517/17425247.2013.769955 DB - PRIME DP - Unbound Medicine ER -