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Impact of impaired sleep on the development of PTSD symptoms in combat veterans: a prospective longitudinal cohort study.
Depress Anxiety. 2013 May; 30(5):469-74.DA

Abstract

BACKGROUND

A significant proportion of soldiers return from deployment with symptoms of fatigue, sleep difficulties, and posttraumatic complaints. Disrupted sleep has been proposed as a contributing factor for the development of posttraumatic stress disorder (PTSD). This study investigates the impact of impaired sleep and nightmares before deployment on the development of PTSD symptoms.

METHOD

We collected reports on insomnia symptoms and nightmares in 453 Dutch service members prior to military deployment to Afghanistan. PTSD symptoms were assessed at 6 months postdeployment. The predictive value of insomnia symptoms and nightmares on the development of PTSD symptoms was assessed with a logistic regression analyses, in which was controlled for predeployment mood and anxiety symptoms.

RESULTS

Self-reported predeployment nightmares predicted PTSD symptoms at 6 months (odds ratio 2.992, 95% confidence interval (CI) 1.096-8.551, P < .05), while predeployment insomnia complaints did not (odds ratio 0.976, 95% CI 0.862-1.155, P > .05).

CONCLUSION

In conclusion, this prospective longitudinal cohort study indicates that the existence of predeployment nightmares is associated with an increased risk for the development of PTSD symptoms. Nightmares may be related to hampered fear extinction memory consolidation, which has been associated with REM sleep.

Authors+Show Affiliations

Research Center Military Mental Health Care, Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23389990

Citation

van Liempt, Saskia, et al. "Impact of Impaired Sleep On the Development of PTSD Symptoms in Combat Veterans: a Prospective Longitudinal Cohort Study." Depression and Anxiety, vol. 30, no. 5, 2013, pp. 469-74.
van Liempt S, van Zuiden M, Westenberg H, et al. Impact of impaired sleep on the development of PTSD symptoms in combat veterans: a prospective longitudinal cohort study. Depress Anxiety. 2013;30(5):469-74.
van Liempt, S., van Zuiden, M., Westenberg, H., Super, A., & Vermetten, E. (2013). Impact of impaired sleep on the development of PTSD symptoms in combat veterans: a prospective longitudinal cohort study. Depression and Anxiety, 30(5), 469-74. https://doi.org/10.1002/da.22054
van Liempt S, et al. Impact of Impaired Sleep On the Development of PTSD Symptoms in Combat Veterans: a Prospective Longitudinal Cohort Study. Depress Anxiety. 2013;30(5):469-74. PubMed PMID: 23389990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of impaired sleep on the development of PTSD symptoms in combat veterans: a prospective longitudinal cohort study. AU - van Liempt,Saskia, AU - van Zuiden,Mirjam, AU - Westenberg,Herman, AU - Super,Arvika, AU - Vermetten,Eric, Y1 - 2013/02/06/ PY - 2012/03/19/received PY - 2012/11/18/revised PY - 2012/12/15/accepted PY - 2013/2/8/entrez PY - 2013/2/8/pubmed PY - 2013/12/27/medline SP - 469 EP - 74 JF - Depression and anxiety JO - Depress Anxiety VL - 30 IS - 5 N2 - BACKGROUND: A significant proportion of soldiers return from deployment with symptoms of fatigue, sleep difficulties, and posttraumatic complaints. Disrupted sleep has been proposed as a contributing factor for the development of posttraumatic stress disorder (PTSD). This study investigates the impact of impaired sleep and nightmares before deployment on the development of PTSD symptoms. METHOD: We collected reports on insomnia symptoms and nightmares in 453 Dutch service members prior to military deployment to Afghanistan. PTSD symptoms were assessed at 6 months postdeployment. The predictive value of insomnia symptoms and nightmares on the development of PTSD symptoms was assessed with a logistic regression analyses, in which was controlled for predeployment mood and anxiety symptoms. RESULTS: Self-reported predeployment nightmares predicted PTSD symptoms at 6 months (odds ratio 2.992, 95% confidence interval (CI) 1.096-8.551, P < .05), while predeployment insomnia complaints did not (odds ratio 0.976, 95% CI 0.862-1.155, P > .05). CONCLUSION: In conclusion, this prospective longitudinal cohort study indicates that the existence of predeployment nightmares is associated with an increased risk for the development of PTSD symptoms. Nightmares may be related to hampered fear extinction memory consolidation, which has been associated with REM sleep. SN - 1520-6394 UR - https://www.unboundmedicine.com/medline/citation/23389990/Impact_of_impaired_sleep_on_the_development_of_PTSD_symptoms_in_combat_veterans:_a_prospective_longitudinal_cohort_study_ L2 - https://doi.org/10.1002/da.22054 DB - PRIME DP - Unbound Medicine ER -