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Dietary fructose in nonalcoholic fatty liver disease.
Hepatology 2013; 57(6):2525-31Hep

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in adults and children. A number of genetic and environmental factors are known to predispose individuals to NAFLD. Certain dietary sugars, particularly fructose, are suspected to contribute to the development of NAFLD and its progression. The increasing quantity of fructose in the diet comes from sugar additives (most commonly sucrose and high fructose corn syrup) in beverages and processed foods. Substantial links have been demonstrated between increased fructose consumption and obesity, dyslipidemia, and insulin resistance. Growing evidence suggests that fructose contributes to the development and severity of NAFLD. In human studies, fructose is associated with increasing hepatic fat, inflammation, and possibly fibrosis. Whether fructose alone can cause NAFLD or if it serves only as a contributor when consumed excessively in the setting of insulin resistance, positive energy balance, and sedentary lifestyle is unknown. Sufficient evidence exists to support clinical recommendations that fructose intake be limited through decreasing foods and drinks high in added (fructose-containing) sugars.

Authors+Show Affiliations

Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23390127

Citation

Vos, Miriam B., and Joel E. Lavine. "Dietary Fructose in Nonalcoholic Fatty Liver Disease." Hepatology (Baltimore, Md.), vol. 57, no. 6, 2013, pp. 2525-31.
Vos MB, Lavine JE. Dietary fructose in nonalcoholic fatty liver disease. Hepatology. 2013;57(6):2525-31.
Vos, M. B., & Lavine, J. E. (2013). Dietary fructose in nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.), 57(6), pp. 2525-31. doi:10.1002/hep.26299.
Vos MB, Lavine JE. Dietary Fructose in Nonalcoholic Fatty Liver Disease. Hepatology. 2013;57(6):2525-31. PubMed PMID: 23390127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fructose in nonalcoholic fatty liver disease. AU - Vos,Miriam B, AU - Lavine,Joel E, Y1 - 2013/05/01/ PY - 2012/10/12/received PY - 2013/01/03/revised PY - 2013/01/15/accepted PY - 2013/2/8/entrez PY - 2013/2/8/pubmed PY - 2013/8/21/medline SP - 2525 EP - 31 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 57 IS - 6 N2 - Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in adults and children. A number of genetic and environmental factors are known to predispose individuals to NAFLD. Certain dietary sugars, particularly fructose, are suspected to contribute to the development of NAFLD and its progression. The increasing quantity of fructose in the diet comes from sugar additives (most commonly sucrose and high fructose corn syrup) in beverages and processed foods. Substantial links have been demonstrated between increased fructose consumption and obesity, dyslipidemia, and insulin resistance. Growing evidence suggests that fructose contributes to the development and severity of NAFLD. In human studies, fructose is associated with increasing hepatic fat, inflammation, and possibly fibrosis. Whether fructose alone can cause NAFLD or if it serves only as a contributor when consumed excessively in the setting of insulin resistance, positive energy balance, and sedentary lifestyle is unknown. Sufficient evidence exists to support clinical recommendations that fructose intake be limited through decreasing foods and drinks high in added (fructose-containing) sugars. SN - 1527-3350 UR - https://www.unboundmedicine.com/medline/citation/23390127/Dietary_fructose_in_nonalcoholic_fatty_liver_disease_ L2 - https://doi.org/10.1002/hep.26299 DB - PRIME DP - Unbound Medicine ER -