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Mediterranean dietary pattern and risk of breast cancer.

Abstract

BACKGROUND

A Mediterranean diet has a recognized beneficial effect on health and longevity, with a protective influence on several cancers. However, its association with breast cancer risk remains unclear.

OBJECTIVE

We aimed to investigate whether adherence to a Mediterranean dietary pattern influences breast cancer risk.

DESIGN

The Swedish Women's Lifestyle and Health cohort study includes 49,258 women aged 30 to 49 years at recruitment in 1991-1992. Consumption of foods and beverages was measured at enrollment using a food frequency questionnaire. A Mediterranean diet score was constructed based on the consumption of alcohol, vegetables, fruits, legumes, cereals, fish, the ratio of unsaturated to saturated fat, and dairy and meat products. Relative risks (RR) for breast cancer and specific tumor characteristics (invasiveness, histological type, estrogen/progesterone receptor status, malignancy grade and stage) associated with this score were estimated using Cox regression controlling for potential confounders.

RESULTS

1,278 incident breast cancers were diagnosed. Adherence to a Mediterranean dietary pattern was not statistically significantly associated with reduced risk of breast cancer overall, or with specific breast tumor characteristics. A RR (95% confidence interval) for breast cancer associated with a two-point increment in the Mediterranean diet score was 1.08 (1.00-1.15) in all women, and 1.10 (1.01-1.21) and 1.02 (0.91-1.15) in premenopausal and postmenopausal women, respectively. When alcohol was excluded from the Mediterranean diet score, results became not statistically significant.

CONCLUSIONS

Adherence to a Mediterranean dietary pattern did not decrease breast cancer risk in this cohort of relatively young women.

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  • Authors+Show Affiliations

    ,

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

    , , , ,

    Source

    PloS one 8:2 2013 pg e55374

    MeSH

    Adult
    Alcohol Drinking
    Body Mass Index
    Breast Neoplasms
    Cohort Studies
    Diet, Mediterranean
    Edible Grain
    Female
    Fruit
    Humans
    Life Style
    Middle Aged
    Postmenopause
    Premenopause
    Risk
    Smoking
    Surveys and Questionnaires
    Sweden
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23390532

    Citation

    Couto, Elisabeth, et al. "Mediterranean Dietary Pattern and Risk of Breast Cancer." PloS One, vol. 8, no. 2, 2013, pp. e55374.
    Couto E, Sandin S, Löf M, et al. Mediterranean dietary pattern and risk of breast cancer. PLoS ONE. 2013;8(2):e55374.
    Couto, E., Sandin, S., Löf, M., Ursin, G., Adami, H. O., & Weiderpass, E. (2013). Mediterranean dietary pattern and risk of breast cancer. PloS One, 8(2), pp. e55374. doi:10.1371/journal.pone.0055374.
    Couto E, et al. Mediterranean Dietary Pattern and Risk of Breast Cancer. PLoS ONE. 2013;8(2):e55374. PubMed PMID: 23390532.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Mediterranean dietary pattern and risk of breast cancer. AU - Couto,Elisabeth, AU - Sandin,Sven, AU - Löf,Marie, AU - Ursin,Giske, AU - Adami,Hans-Olov, AU - Weiderpass,Elisabete, Y1 - 2013/02/04/ PY - 2012/09/12/received PY - 2012/12/22/accepted PY - 2013/2/8/entrez PY - 2013/2/8/pubmed PY - 2013/7/20/medline SP - e55374 EP - e55374 JF - PloS one JO - PLoS ONE VL - 8 IS - 2 N2 - BACKGROUND: A Mediterranean diet has a recognized beneficial effect on health and longevity, with a protective influence on several cancers. However, its association with breast cancer risk remains unclear. OBJECTIVE: We aimed to investigate whether adherence to a Mediterranean dietary pattern influences breast cancer risk. DESIGN: The Swedish Women's Lifestyle and Health cohort study includes 49,258 women aged 30 to 49 years at recruitment in 1991-1992. Consumption of foods and beverages was measured at enrollment using a food frequency questionnaire. A Mediterranean diet score was constructed based on the consumption of alcohol, vegetables, fruits, legumes, cereals, fish, the ratio of unsaturated to saturated fat, and dairy and meat products. Relative risks (RR) for breast cancer and specific tumor characteristics (invasiveness, histological type, estrogen/progesterone receptor status, malignancy grade and stage) associated with this score were estimated using Cox regression controlling for potential confounders. RESULTS: 1,278 incident breast cancers were diagnosed. Adherence to a Mediterranean dietary pattern was not statistically significantly associated with reduced risk of breast cancer overall, or with specific breast tumor characteristics. A RR (95% confidence interval) for breast cancer associated with a two-point increment in the Mediterranean diet score was 1.08 (1.00-1.15) in all women, and 1.10 (1.01-1.21) and 1.02 (0.91-1.15) in premenopausal and postmenopausal women, respectively. When alcohol was excluded from the Mediterranean diet score, results became not statistically significant. CONCLUSIONS: Adherence to a Mediterranean dietary pattern did not decrease breast cancer risk in this cohort of relatively young women. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23390532/Mediterranean_dietary_pattern_and_risk_of_breast_cancer_ L2 - http://dx.plos.org/10.1371/journal.pone.0055374 DB - PRIME DP - Unbound Medicine ER -