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Scrub typhus in patients reporting with acute febrile illness at a tertiary health care institution in Goa.
Indian J Med Res. 2012 Dec; 136(6):1020-4.IJ

Abstract

BACKGROUND & OBJECTIVES

Scrub typhus is one of the differential diagnoses of haemorrhagic fevers especially if associated with jaundice and/or renal failure. Goa State in the western region of India has been witnessing increased incidence of such fevers, therefore, the present study was undertaken to identify whether scrub typhus is the aetiological agent.

METHODS

Adult patients presenting with undiagnosed febrile illness between June 2009 to October 2010, were evaluated. Testing was done using a commercial ELISA kit for specific IgM antibodies against Orientia tsutsugamushi.

RESULTS

Of the 44 patients included in the study, 15 (34%) were found to be positive for IGM antibodies against O. tsutsugamushi. The cases were seen mainly in the months between July to November. The common symptoms noted were fever, myalgias, gastrointestinal complaints, followed by breathlessness, rash and jaundice. The pathognomonic features such as eschar and lymphadenopathy were seen only in two patients. Nearly two third of the patients had leukocytosis (67%) and low serum albumin (60%). The most common complication noticed was hepatitis (80%) followed by acute respiratory distress syndrome (ARDS) (60%), thrombocytopenia (40%) and acute renal failure (33%). Five patients died in the course of illness.

INTERPRETATION & CONCLUSIONS

Our results showed that scrub typhus should be considered in the differential diagnosis of acute febrile illness associated with gastrointestinal symptoms, rash, myalgia , including those with organ dysfunctions such as hepatorenal syndrome, coagulopathy or ARDS. Empirical treatment with doxycycline or macrolides may be given in cases with strong suspicion of scrub typhus.

Authors+Show Affiliations

Department of Medicine, Goa Medical College, Goa, India. kedarnarvenkar@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23391799

Citation

Narvencar, Kedareshwar P S., et al. "Scrub Typhus in Patients Reporting With Acute Febrile Illness at a Tertiary Health Care Institution in Goa." The Indian Journal of Medical Research, vol. 136, no. 6, 2012, pp. 1020-4.
Narvencar KP, Rodrigues S, Nevrekar RP, et al. Scrub typhus in patients reporting with acute febrile illness at a tertiary health care institution in Goa. Indian J Med Res. 2012;136(6):1020-4.
Narvencar, K. P., Rodrigues, S., Nevrekar, R. P., Dias, L., Dias, A., Vaz, M., & Gomes, E. (2012). Scrub typhus in patients reporting with acute febrile illness at a tertiary health care institution in Goa. The Indian Journal of Medical Research, 136(6), 1020-4.
Narvencar KP, et al. Scrub Typhus in Patients Reporting With Acute Febrile Illness at a Tertiary Health Care Institution in Goa. Indian J Med Res. 2012;136(6):1020-4. PubMed PMID: 23391799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scrub typhus in patients reporting with acute febrile illness at a tertiary health care institution in Goa. AU - Narvencar,Kedareshwar P S, AU - Rodrigues,Savio, AU - Nevrekar,Ramnath P, AU - Dias,Lydia, AU - Dias,Amit, AU - Vaz,Marina, AU - Gomes,E, PY - 2013/2/9/entrez PY - 2013/2/9/pubmed PY - 2013/12/16/medline SP - 1020 EP - 4 JF - The Indian journal of medical research JO - Indian J Med Res VL - 136 IS - 6 N2 - BACKGROUND & OBJECTIVES: Scrub typhus is one of the differential diagnoses of haemorrhagic fevers especially if associated with jaundice and/or renal failure. Goa State in the western region of India has been witnessing increased incidence of such fevers, therefore, the present study was undertaken to identify whether scrub typhus is the aetiological agent. METHODS: Adult patients presenting with undiagnosed febrile illness between June 2009 to October 2010, were evaluated. Testing was done using a commercial ELISA kit for specific IgM antibodies against Orientia tsutsugamushi. RESULTS: Of the 44 patients included in the study, 15 (34%) were found to be positive for IGM antibodies against O. tsutsugamushi. The cases were seen mainly in the months between July to November. The common symptoms noted were fever, myalgias, gastrointestinal complaints, followed by breathlessness, rash and jaundice. The pathognomonic features such as eschar and lymphadenopathy were seen only in two patients. Nearly two third of the patients had leukocytosis (67%) and low serum albumin (60%). The most common complication noticed was hepatitis (80%) followed by acute respiratory distress syndrome (ARDS) (60%), thrombocytopenia (40%) and acute renal failure (33%). Five patients died in the course of illness. INTERPRETATION & CONCLUSIONS: Our results showed that scrub typhus should be considered in the differential diagnosis of acute febrile illness associated with gastrointestinal symptoms, rash, myalgia , including those with organ dysfunctions such as hepatorenal syndrome, coagulopathy or ARDS. Empirical treatment with doxycycline or macrolides may be given in cases with strong suspicion of scrub typhus. SN - 0971-5916 UR - https://www.unboundmedicine.com/medline/citation/23391799/Scrub_typhus_in_patients_reporting_with_acute_febrile_illness_at_a_tertiary_health_care_institution_in_Goa_ L2 - http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2012;volume=136;issue=6;spage=1020;epage=1024;aulast=Narvencar DB - PRIME DP - Unbound Medicine ER -