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Androgens concentrations and second-to fourth-digit ratio (2D:4D) in girls with congenital adrenal hyperplasia (21-hydroxylase deficiency).
Neuro Endocrinol Lett. 2012; 33(8):787-91.NE

Abstract

OBJECTIVES

Excessive hyperandrogenism, though proper hydrocortisone supplementation is a frequent clinical problem in girls with congenital adrenal hyperplasia (CAH). This may result from autonomic regulation of androgen production established in prenatal life. It has been suggested that the length of the second finger relative to the length of the fourth finger (2D;4D ratio) is negatively related to prenatal testosterone concentration.

DESIGN AND SETTING

The retrospective study aimed to establish the relationship between the level of androgenization in utero determined using 2D:4D ratio and serum androgen concentrations in treated girls with CAH (21-OH deficiency) has been performed on 19 girls with CAH (21-OH deficiency) at the age of 3.7-19 years (mean 13.8 ± 4.07 years). All subjects were adequately treated with hydrocortisone (10-19 mg/m2; mean 13.81 ± 4.07 mg/m2). Anthropometric measurements of digits length were performed in all girls on X-rays obtained for bone age estimation. Apart from it, serum androgens concentrations (testosterone, androstenedione, s-DHEA) and 17-OH-progesterone (17-OHP) were assayed.

RESULTS

Mean androgens serum concentrations in examined group were: testosterone 150.21 ± 155.44 ng/ml; androstenedione 4.15 ± 5.32 ng/ml, s-DHEA 70.39 ± 85.52 µg/dl. Mean 2D:4D ratio was 0.96 ± 0.04. Analysis of correlation showed positive linear correlations between testosterone, s-DHEA and 2D:4D ratio (r=0.53, p=0.023 and r=0.53; p=0.019, respectively).

CONCLUSIONS

2D:4D ratio parameter may be a simple test in indentification of female CAH patients prone to excessive androgen secretion despite proper treatment. The autonomization of adrenal androgens production in foetal life may cause its elevated levels in female patients with CAH although treated adequately.

Authors+Show Affiliations

Department of Paediatrics, Medical University of Silesia, Katowice, Poland. smina@poczta.onet.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23391972

Citation

Oswiecimska, Joanna M., et al. "Androgens Concentrations and Second-to Fourth-digit Ratio (2D:4D) in Girls With Congenital Adrenal Hyperplasia (21-hydroxylase Deficiency)." Neuro Endocrinology Letters, vol. 33, no. 8, 2012, pp. 787-91.
Oswiecimska JM, Ksiazek A, Sygulla K, et al. Androgens concentrations and second-to fourth-digit ratio (2D:4D) in girls with congenital adrenal hyperplasia (21-hydroxylase deficiency). Neuro Endocrinol Lett. 2012;33(8):787-91.
Oswiecimska, J. M., Ksiazek, A., Sygulla, K., Pys-Spychala, M., Roczniak, G. R., Roczniak, W., Stojewska, M., & Ziora, K. (2012). Androgens concentrations and second-to fourth-digit ratio (2D:4D) in girls with congenital adrenal hyperplasia (21-hydroxylase deficiency). Neuro Endocrinology Letters, 33(8), 787-91.
Oswiecimska JM, et al. Androgens Concentrations and Second-to Fourth-digit Ratio (2D:4D) in Girls With Congenital Adrenal Hyperplasia (21-hydroxylase Deficiency). Neuro Endocrinol Lett. 2012;33(8):787-91. PubMed PMID: 23391972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Androgens concentrations and second-to fourth-digit ratio (2D:4D) in girls with congenital adrenal hyperplasia (21-hydroxylase deficiency). AU - Oswiecimska,Joanna M, AU - Ksiazek,Agnieszka, AU - Sygulla,Katarzyna, AU - Pys-Spychala,Magdalena, AU - Roczniak,Grzegorz R, AU - Roczniak,Wojciech, AU - Stojewska,Malgorzata, AU - Ziora,Katarzyna, PY - 2012/09/05/received PY - 2012/11/25/accepted PY - 2013/2/9/entrez PY - 2013/2/9/pubmed PY - 2013/4/12/medline SP - 787 EP - 91 JF - Neuro endocrinology letters JO - Neuro Endocrinol. Lett. VL - 33 IS - 8 N2 - OBJECTIVES: Excessive hyperandrogenism, though proper hydrocortisone supplementation is a frequent clinical problem in girls with congenital adrenal hyperplasia (CAH). This may result from autonomic regulation of androgen production established in prenatal life. It has been suggested that the length of the second finger relative to the length of the fourth finger (2D;4D ratio) is negatively related to prenatal testosterone concentration. DESIGN AND SETTING: The retrospective study aimed to establish the relationship between the level of androgenization in utero determined using 2D:4D ratio and serum androgen concentrations in treated girls with CAH (21-OH deficiency) has been performed on 19 girls with CAH (21-OH deficiency) at the age of 3.7-19 years (mean 13.8 ± 4.07 years). All subjects were adequately treated with hydrocortisone (10-19 mg/m2; mean 13.81 ± 4.07 mg/m2). Anthropometric measurements of digits length were performed in all girls on X-rays obtained for bone age estimation. Apart from it, serum androgens concentrations (testosterone, androstenedione, s-DHEA) and 17-OH-progesterone (17-OHP) were assayed. RESULTS: Mean androgens serum concentrations in examined group were: testosterone 150.21 ± 155.44 ng/ml; androstenedione 4.15 ± 5.32 ng/ml, s-DHEA 70.39 ± 85.52 µg/dl. Mean 2D:4D ratio was 0.96 ± 0.04. Analysis of correlation showed positive linear correlations between testosterone, s-DHEA and 2D:4D ratio (r=0.53, p=0.023 and r=0.53; p=0.019, respectively). CONCLUSIONS: 2D:4D ratio parameter may be a simple test in indentification of female CAH patients prone to excessive androgen secretion despite proper treatment. The autonomization of adrenal androgens production in foetal life may cause its elevated levels in female patients with CAH although treated adequately. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/23391972/Androgens_concentrations_and_second_to_fourth_digit_ratio__2D:4D__in_girls_with_congenital_adrenal_hyperplasia__21_hydroxylase_deficiency__ L2 - http://babysfirsttest.org/newborn-screening/conditions/congenital-adrenal-hyperplasia DB - PRIME DP - Unbound Medicine ER -