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Necrotizing infundibular crystalline folliculitis manifesting as a perforating mucinosis: a case report.
Am J Dermatopathol. 2013 Oct; 35(7):757-60.AJ

Abstract

: Necrotizing infundibular crystalline folliculitis (NICF) is a rare entity manifesting as waxy folliculocentric papules comprised of filamentous birefringent crystalline deposits. We report a case of NICF in an 85-year-old man, presenting as gritty, cream-colored, and erythematous papules across the midline back. Biopsy demonstrated a pale plug comprised of copious mucin. The diagnostic crystals were initially overlooked because of softening of the paraffin block with 10% ammonia solution, which dissolved the crystals in the initial sections. X-ray microanalysis confirmed the organic nature of the crystals. This is the first report of NICF from North America. Our case highlights the presence of mucin in some cases of NICF and serves as a cautionary tale on the pitfalls of postprocessing artifacts in the histology laboratory.

Authors+Show Affiliations

*Department of Pathology and Laboratory Medicine, and †Division of Dermatology, University of Kansas Medical Center, Kansas City, KS ‡Department of Pathology, SUNY Upstate Medical University, Syracuse, NY.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23392135

Citation

Fraga, Garth R., et al. "Necrotizing Infundibular Crystalline Folliculitis Manifesting as a Perforating Mucinosis: a Case Report." The American Journal of Dermatopathology, vol. 35, no. 7, 2013, pp. 757-60.
Fraga GR, Gadzia JE, Abraham JL, et al. Necrotizing infundibular crystalline folliculitis manifesting as a perforating mucinosis: a case report. Am J Dermatopathol. 2013;35(7):757-60.
Fraga, G. R., Gadzia, J. E., Abraham, J. L., & Machan, M. (2013). Necrotizing infundibular crystalline folliculitis manifesting as a perforating mucinosis: a case report. The American Journal of Dermatopathology, 35(7), 757-60. https://doi.org/10.1097/DAD.0b013e31827eeb71
Fraga GR, et al. Necrotizing Infundibular Crystalline Folliculitis Manifesting as a Perforating Mucinosis: a Case Report. Am J Dermatopathol. 2013;35(7):757-60. PubMed PMID: 23392135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrotizing infundibular crystalline folliculitis manifesting as a perforating mucinosis: a case report. AU - Fraga,Garth R, AU - Gadzia,Joseph E, AU - Abraham,Jerrold L, AU - Machan,Mac, PY - 2013/2/9/entrez PY - 2013/2/9/pubmed PY - 2014/4/17/medline SP - 757 EP - 60 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 35 IS - 7 N2 - : Necrotizing infundibular crystalline folliculitis (NICF) is a rare entity manifesting as waxy folliculocentric papules comprised of filamentous birefringent crystalline deposits. We report a case of NICF in an 85-year-old man, presenting as gritty, cream-colored, and erythematous papules across the midline back. Biopsy demonstrated a pale plug comprised of copious mucin. The diagnostic crystals were initially overlooked because of softening of the paraffin block with 10% ammonia solution, which dissolved the crystals in the initial sections. X-ray microanalysis confirmed the organic nature of the crystals. This is the first report of NICF from North America. Our case highlights the presence of mucin in some cases of NICF and serves as a cautionary tale on the pitfalls of postprocessing artifacts in the histology laboratory. SN - 1533-0311 UR - https://www.unboundmedicine.com/medline/citation/23392135/Necrotizing_infundibular_crystalline_folliculitis_manifesting_as_a_perforating_mucinosis:_a_case_report_ L2 - https://doi.org/10.1097/DAD.0b013e31827eeb71 DB - PRIME DP - Unbound Medicine ER -