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Antidiabetic effect of taurine in cultured rat skeletal l6 myotubes.
Adv Exp Med Biol. 2013; 775:311-20.AE

Abstract

Taurine (2-aminoethanesulfonic acid), a sulfur-containing β-amino acid, is found in all animal cells at millimolar concentrations and has been reported to show various health promoting activities including antidiabetic properties. The beneficial effects of taurine in diabetes mellitus have been known. However, the exact mechanism of hypoglycemic action of taurine is not properly defined. In this study, we investigated antidiabetic effect of taurine in the cell culture system using rat skeletal muscle cells. In cultured rat skeletal L6 myotubes, we studied the effect of taurine (0-100 μM) on glucose uptake to plasma membrane from the aspects of AMP-activated protein kinase (AMPK) signaling. Taurine stimulated glucose uptake in a dose-dependent manner by activating AMPK signaling. From these results, it may suggest that taurine show antidiabetic effect by stimulating insulin-independent glucose uptake in rat skeletal muscle.

Authors+Show Affiliations

Department of Applied Biological Chemistry, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23392945

Citation

Cheong, Sun Hee, and Kyung Ja Chang. "Antidiabetic Effect of Taurine in Cultured Rat Skeletal L6 Myotubes." Advances in Experimental Medicine and Biology, vol. 775, 2013, pp. 311-20.
Cheong SH, Chang KJ. Antidiabetic effect of taurine in cultured rat skeletal l6 myotubes. Adv Exp Med Biol. 2013;775:311-20.
Cheong, S. H., & Chang, K. J. (2013). Antidiabetic effect of taurine in cultured rat skeletal l6 myotubes. Advances in Experimental Medicine and Biology, 775, 311-20. https://doi.org/10.1007/978-1-4614-6130-2_26
Cheong SH, Chang KJ. Antidiabetic Effect of Taurine in Cultured Rat Skeletal L6 Myotubes. Adv Exp Med Biol. 2013;775:311-20. PubMed PMID: 23392945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic effect of taurine in cultured rat skeletal l6 myotubes. AU - Cheong,Sun Hee, AU - Chang,Kyung Ja, PY - 2013/2/9/entrez PY - 2013/2/9/pubmed PY - 2013/6/13/medline SP - 311 EP - 20 JF - Advances in experimental medicine and biology JO - Adv. Exp. Med. Biol. VL - 775 N2 - Taurine (2-aminoethanesulfonic acid), a sulfur-containing β-amino acid, is found in all animal cells at millimolar concentrations and has been reported to show various health promoting activities including antidiabetic properties. The beneficial effects of taurine in diabetes mellitus have been known. However, the exact mechanism of hypoglycemic action of taurine is not properly defined. In this study, we investigated antidiabetic effect of taurine in the cell culture system using rat skeletal muscle cells. In cultured rat skeletal L6 myotubes, we studied the effect of taurine (0-100 μM) on glucose uptake to plasma membrane from the aspects of AMP-activated protein kinase (AMPK) signaling. Taurine stimulated glucose uptake in a dose-dependent manner by activating AMPK signaling. From these results, it may suggest that taurine show antidiabetic effect by stimulating insulin-independent glucose uptake in rat skeletal muscle. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/23392945/Antidiabetic_effect_of_taurine_in_cultured_rat_skeletal_l6_myotubes_ L2 - https://dx.doi.org/10.1007/978-1-4614-6130-2_26 DB - PRIME DP - Unbound Medicine ER -