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Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes.
Diabetes Care 2013; 36(5):1361-7DC

Abstract

OBJECTIVE

To study the association between vitamin D status and the risk of incident impaired fasting glucose (IFG) and diabetes in a population-based cohort of diabetes-free subjects.

RESEARCH DESIGN AND METHODS

In a historical prospective cohort study of subjects from the Clalit Health Services database, which includes information on nearly 4 million people, diabetes-free subjects aged 40-70 years with serum 25-hydroxycholecalciferol (25-OHD) measurements available were followed for 2 years to assess the development of IFG and diabetes in five 25-OHD subgroups: ≥25, 25.1-37.5, 37.6-50, 50.1-75, and >75 nmol/L.

RESULTS

The baseline cohort included 117,960 adults: 83,526 normoglycemic subjects and 34,434 subjects with IFG. During follow-up, 8,629 subjects (10.3% of the normoglycemic group) developed IFG, and 2,162 subjects (1.8% of the total cohort) progressed to diabetes. A multivariable model adjusted for age, sex, population group, immigrant status, BMI, season of vitamin D measurement, LDL and HDL cholesterol, triglycerides, estimated glomerular filtration rate, history of hypertension or cardiovascular disease, Charlson comorbidity index, smoking, and socioeconomic status revealed an inverse association between 25-OHD and the risk of progression to IFG and diabetes. The odds of transitioning from normoglycemia to IFG, from normoglycemia to diabetes, and from IFG to diabetes in subjects with a 25-OHD level ≤25 nmol/L were greater than those of subjects with a 25-OHD level >75 nmol/L [odds ratio 1.13 (95% CI 1.03-1.24), 1.77 (1.11-2.83), and 1.43 (1.16-1.76), respectively].

CONCLUSIONS

Vitamin D deficiency appears to be an independent risk factor for the development of IFG and diabetes.

Authors+Show Affiliations

Clalit Health Services, Jerusalem, Israel. tsuranat@netvision.net.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23393216

Citation

Tsur, Anat, et al. "Decreased Serum Concentrations of 25-hydroxycholecalciferol Are Associated With Increased Risk of Progression to Impaired Fasting Glucose and Diabetes." Diabetes Care, vol. 36, no. 5, 2013, pp. 1361-7.
Tsur A, Feldman BS, Feldhammer I, et al. Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes. Diabetes Care. 2013;36(5):1361-7.
Tsur, A., Feldman, B. S., Feldhammer, I., Hoshen, M. B., Leibowitz, G., & Balicer, R. D. (2013). Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes. Diabetes Care, 36(5), pp. 1361-7. doi:10.2337/dc12-1050.
Tsur A, et al. Decreased Serum Concentrations of 25-hydroxycholecalciferol Are Associated With Increased Risk of Progression to Impaired Fasting Glucose and Diabetes. Diabetes Care. 2013;36(5):1361-7. PubMed PMID: 23393216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes. AU - Tsur,Anat, AU - Feldman,Becca S, AU - Feldhammer,Ilan, AU - Hoshen,Moshe B, AU - Leibowitz,Gil, AU - Balicer,Ran D, Y1 - 2013/02/07/ PY - 2013/2/9/entrez PY - 2013/2/9/pubmed PY - 2013/12/16/medline SP - 1361 EP - 7 JF - Diabetes care JO - Diabetes Care VL - 36 IS - 5 N2 - OBJECTIVE: To study the association between vitamin D status and the risk of incident impaired fasting glucose (IFG) and diabetes in a population-based cohort of diabetes-free subjects. RESEARCH DESIGN AND METHODS: In a historical prospective cohort study of subjects from the Clalit Health Services database, which includes information on nearly 4 million people, diabetes-free subjects aged 40-70 years with serum 25-hydroxycholecalciferol (25-OHD) measurements available were followed for 2 years to assess the development of IFG and diabetes in five 25-OHD subgroups: ≥25, 25.1-37.5, 37.6-50, 50.1-75, and >75 nmol/L. RESULTS: The baseline cohort included 117,960 adults: 83,526 normoglycemic subjects and 34,434 subjects with IFG. During follow-up, 8,629 subjects (10.3% of the normoglycemic group) developed IFG, and 2,162 subjects (1.8% of the total cohort) progressed to diabetes. A multivariable model adjusted for age, sex, population group, immigrant status, BMI, season of vitamin D measurement, LDL and HDL cholesterol, triglycerides, estimated glomerular filtration rate, history of hypertension or cardiovascular disease, Charlson comorbidity index, smoking, and socioeconomic status revealed an inverse association between 25-OHD and the risk of progression to IFG and diabetes. The odds of transitioning from normoglycemia to IFG, from normoglycemia to diabetes, and from IFG to diabetes in subjects with a 25-OHD level ≤25 nmol/L were greater than those of subjects with a 25-OHD level >75 nmol/L [odds ratio 1.13 (95% CI 1.03-1.24), 1.77 (1.11-2.83), and 1.43 (1.16-1.76), respectively]. CONCLUSIONS: Vitamin D deficiency appears to be an independent risk factor for the development of IFG and diabetes. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/23393216/Decreased_serum_concentrations_of_25_hydroxycholecalciferol_are_associated_with_increased_risk_of_progression_to_impaired_fasting_glucose_and_diabetes_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=23393216 DB - PRIME DP - Unbound Medicine ER -