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Association of open-angle glaucoma with perfusion pressure status in the Thessaloniki Eye Study.
Am J Ophthalmol 2013; 155(5):843-51AJ

Abstract

PURPOSE

To investigate the association of open-angle glaucoma (OAG), primary open-angle glaucoma (POAG), and pseudoexfoliative glaucoma (PEXG) with ocular perfusion pressure status (ocular perfusion pressure with or without antihypertensive treatment).

DESIGN

Cross-sectional, population-based study.

METHODS

A total of 2554 randomly selected, ≥ 60-year old subjects participated in the Thessaloniki Eye Study. Only clinic-visit participants (n = 2261), who had uniformly collected data, were included in the analyses. A logistic regression model was run for OAG in all clinic-visit participants; covariates included age, sex, diastolic ocular perfusion pressure, antihypertensive treatment, intraocular pressure (IOP), IOP-lowering treatment, pseudoexfoliation, and vascular factors identified as risk factors for glaucoma in a previous analysis. Similar logistic regression models were run separately for POAG and PEXG. In addition, logistic regression models were run for OAG, POAG, and PEXG in subjects with and without antihypertensive treatment. Also, logistic regression models were run to assess the role of systolic ocular perfusion pressure in OAG, POAG, and PEXG.

RESULTS

Among clinic-visits, 1212 subjects (53.7%) were using antihypertensive treatment. An association of borderline significance was found between low diastolic ocular perfusion pressure and POAG (OR = 0.84 per 10 mm Hg, 95% CI = 0.70-1.01, P = .059). The effect of antihypertensive treatment on POAG was not statistically significant (OR = 1.20, 95% CI = 0.75-1.91, P = .45). In subgroup analyses, diastolic ocular perfusion pressure was significantly associated with POAG in subjects using antihypertensive treatment (OR = 0.78 per 10 mm Hg, 95% CI = 0.62-0.97, P = .028). No association was found between diastolic ocular perfusion pressure and PEXG, regardless of the use of antihypertensive treatment. No associations were found between systolic ocular perfusion pressure and OAG, POAG, or PEXG, regardless of the use of antihypertensive treatment.

CONCLUSIONS

Low diastolic ocular perfusion pressure may be associated with increased risk for POAG. This association was confirmed in subjects treated for systemic hypertension in subgroup analysis. This may support the hypothesis that the concept of ocular perfusion pressure status may be more relevant to glaucoma pathogenesis than ocular perfusion pressure alone.

Authors+Show Affiliations

Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, American Hellenic Educational Progressive Association (AHEPA) Hospital, Thessaloniki, Greece. ftopouzis@otenet.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23394905

Citation

Topouzis, Fotis, et al. "Association of Open-angle Glaucoma With Perfusion Pressure Status in the Thessaloniki Eye Study." American Journal of Ophthalmology, vol. 155, no. 5, 2013, pp. 843-51.
Topouzis F, Wilson MR, Harris A, et al. Association of open-angle glaucoma with perfusion pressure status in the Thessaloniki Eye Study. Am J Ophthalmol. 2013;155(5):843-51.
Topouzis, F., Wilson, M. R., Harris, A., Founti, P., Yu, F., Anastasopoulos, E., ... Coleman, A. L. (2013). Association of open-angle glaucoma with perfusion pressure status in the Thessaloniki Eye Study. American Journal of Ophthalmology, 155(5), pp. 843-51. doi:10.1016/j.ajo.2012.12.007.
Topouzis F, et al. Association of Open-angle Glaucoma With Perfusion Pressure Status in the Thessaloniki Eye Study. Am J Ophthalmol. 2013;155(5):843-51. PubMed PMID: 23394905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of open-angle glaucoma with perfusion pressure status in the Thessaloniki Eye Study. AU - Topouzis,Fotis, AU - Wilson,M Roy, AU - Harris,Alon, AU - Founti,Panayiota, AU - Yu,Fei, AU - Anastasopoulos,Eleftherios, AU - Pappas,Theofanis, AU - Koskosas,Archimidis, AU - Salonikiou,Angeliki, AU - Coleman,Anne L, Y1 - 2013/02/06/ PY - 2011/11/01/received PY - 2012/11/30/revised PY - 2012/12/05/accepted PY - 2013/2/12/entrez PY - 2013/2/12/pubmed PY - 2013/6/5/medline SP - 843 EP - 51 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 155 IS - 5 N2 - PURPOSE: To investigate the association of open-angle glaucoma (OAG), primary open-angle glaucoma (POAG), and pseudoexfoliative glaucoma (PEXG) with ocular perfusion pressure status (ocular perfusion pressure with or without antihypertensive treatment). DESIGN: Cross-sectional, population-based study. METHODS: A total of 2554 randomly selected, ≥ 60-year old subjects participated in the Thessaloniki Eye Study. Only clinic-visit participants (n = 2261), who had uniformly collected data, were included in the analyses. A logistic regression model was run for OAG in all clinic-visit participants; covariates included age, sex, diastolic ocular perfusion pressure, antihypertensive treatment, intraocular pressure (IOP), IOP-lowering treatment, pseudoexfoliation, and vascular factors identified as risk factors for glaucoma in a previous analysis. Similar logistic regression models were run separately for POAG and PEXG. In addition, logistic regression models were run for OAG, POAG, and PEXG in subjects with and without antihypertensive treatment. Also, logistic regression models were run to assess the role of systolic ocular perfusion pressure in OAG, POAG, and PEXG. RESULTS: Among clinic-visits, 1212 subjects (53.7%) were using antihypertensive treatment. An association of borderline significance was found between low diastolic ocular perfusion pressure and POAG (OR = 0.84 per 10 mm Hg, 95% CI = 0.70-1.01, P = .059). The effect of antihypertensive treatment on POAG was not statistically significant (OR = 1.20, 95% CI = 0.75-1.91, P = .45). In subgroup analyses, diastolic ocular perfusion pressure was significantly associated with POAG in subjects using antihypertensive treatment (OR = 0.78 per 10 mm Hg, 95% CI = 0.62-0.97, P = .028). No association was found between diastolic ocular perfusion pressure and PEXG, regardless of the use of antihypertensive treatment. No associations were found between systolic ocular perfusion pressure and OAG, POAG, or PEXG, regardless of the use of antihypertensive treatment. CONCLUSIONS: Low diastolic ocular perfusion pressure may be associated with increased risk for POAG. This association was confirmed in subjects treated for systemic hypertension in subgroup analysis. This may support the hypothesis that the concept of ocular perfusion pressure status may be more relevant to glaucoma pathogenesis than ocular perfusion pressure alone. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/23394905/Association_of_open_angle_glaucoma_with_perfusion_pressure_status_in_the_Thessaloniki_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(12)00861-6 DB - PRIME DP - Unbound Medicine ER -