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Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18(AV-45) positron emission tomography.
Am J Geriatr Psychiatry 2013; 21(3):272-8AJ

Abstract

OBJECTIVE

To examine the association between regional brain uptake of a novel amyloid positron emission tomography (PET) tracer florbetapir F 18 ([(18)F]-AV-45) and cognitive performance in a pilot study.

DESIGN

Cross-sectional comparison of [(18)F]-AV-45 in AD patients versus controls.

SETTING

Three specialty memory clinics.

PARTICIPANTS

Eleven participants with probable Alzheimer disease (AD) by NINDS/ADRDA criteria and 15 healthy comparison (HC) participants.

MEASUREMENTS

Participants underwent PET imaging following a 370 MBq (10 mCi) intravenous administration of [(18)F]-AV-45. Regional/cerebellar standardized uptake value ratios (SUVRs) were calculated. Cognition was assessed using Mini-Mental State Examination, Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Wechsler Logical Memory IA (immediate recall) test (LMIA), and verbal category fluency.

RESULTS

Greater [(18)F]-AV-45 SUVR was associated with poorer performance on all cognitive tests. In the HC group, occipital, parietal, precuneus, temporal, and cortical average SUVR was associated with greater ADAS-Cog, and greater anterior cingulate SUVR was associated with lower LMIA. Two HC participants had [(18)F]-AV-45 cortical/cerebellar SUVR greater than 1.5, one of whom had deficits in episodic recall and on follow-up met criteria for amnestic mild cognitive impairment.

CONCLUSION

[(18)F]-AV-45 SUVR in several brain regions was associated with worse global cognitive performance particularly in HC, suggesting its potential as a marker of preclinical AD.

Authors+Show Affiliations

Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA. prosenb9@jhmi.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23395194

Citation

Rosenberg, Paul B., et al. "Cognition and Amyloid Load in Alzheimer Disease Imaged With Florbetapir F 18(AV-45) Positron Emission Tomography." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 21, no. 3, 2013, pp. 272-8.
Rosenberg PB, Wong DF, Edell SL, et al. Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18(AV-45) positron emission tomography. Am J Geriatr Psychiatry. 2013;21(3):272-8.
Rosenberg, P. B., Wong, D. F., Edell, S. L., Ross, J. S., Joshi, A. D., Brašić, J. R., ... Lyketsos, C. G. (2013). Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18(AV-45) positron emission tomography. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 21(3), pp. 272-8. doi:10.1016/j.jagp.2012.11.016.
Rosenberg PB, et al. Cognition and Amyloid Load in Alzheimer Disease Imaged With Florbetapir F 18(AV-45) Positron Emission Tomography. Am J Geriatr Psychiatry. 2013;21(3):272-8. PubMed PMID: 23395194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18(AV-45) positron emission tomography. AU - Rosenberg,Paul B, AU - Wong,D F, AU - Edell,S L, AU - Ross,J S, AU - Joshi,A D, AU - Brašić,J R, AU - Zhou,Y, AU - Raymont,V, AU - Kumar,A, AU - Ravert,H T, AU - Dannals,R F, AU - Pontecorvo,M J, AU - Skovronsky,D M, AU - Lyketsos,C G, PY - 2010/06/28/received PY - 2010/12/25/revised PY - 2011/03/29/accepted PY - 2013/2/12/entrez PY - 2013/2/12/pubmed PY - 2014/9/6/medline SP - 272 EP - 8 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 21 IS - 3 N2 - OBJECTIVE: To examine the association between regional brain uptake of a novel amyloid positron emission tomography (PET) tracer florbetapir F 18 ([(18)F]-AV-45) and cognitive performance in a pilot study. DESIGN: Cross-sectional comparison of [(18)F]-AV-45 in AD patients versus controls. SETTING: Three specialty memory clinics. PARTICIPANTS: Eleven participants with probable Alzheimer disease (AD) by NINDS/ADRDA criteria and 15 healthy comparison (HC) participants. MEASUREMENTS: Participants underwent PET imaging following a 370 MBq (10 mCi) intravenous administration of [(18)F]-AV-45. Regional/cerebellar standardized uptake value ratios (SUVRs) were calculated. Cognition was assessed using Mini-Mental State Examination, Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Wechsler Logical Memory IA (immediate recall) test (LMIA), and verbal category fluency. RESULTS: Greater [(18)F]-AV-45 SUVR was associated with poorer performance on all cognitive tests. In the HC group, occipital, parietal, precuneus, temporal, and cortical average SUVR was associated with greater ADAS-Cog, and greater anterior cingulate SUVR was associated with lower LMIA. Two HC participants had [(18)F]-AV-45 cortical/cerebellar SUVR greater than 1.5, one of whom had deficits in episodic recall and on follow-up met criteria for amnestic mild cognitive impairment. CONCLUSION: [(18)F]-AV-45 SUVR in several brain regions was associated with worse global cognitive performance particularly in HC, suggesting its potential as a marker of preclinical AD. SN - 1545-7214 UR - https://www.unboundmedicine.com/medline/citation/23395194/Cognition_and_amyloid_load_in_Alzheimer_disease_imaged_with_florbetapir_F_18_AV_45__positron_emission_tomography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1064-7481(12)00078-4 DB - PRIME DP - Unbound Medicine ER -