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Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ.
Mol Pharmacol. 2013 May; 83(5):907-18.MP

Abstract

The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is the fourth and most recently discovered member of the opioid receptor superfamily that also includes μ, δ, and κ opioid receptor subtypes (MOR, DOR, and KOR, respectively). The widespread anatomic distribution of the NOP receptor enables the modulation of several physiologic processes by its endogenous agonist, N/OFQ. Accordingly, the NOP receptor has gained a lot of attention as a potential target for the development of ligands with therapeutic use in several pathophysiological states. NOP receptor activation frequently results in effects opposing classic opioid receptor action; therefore, regulation of the NOP receptor and conditions affecting its modulatory tone are important to understand. Mounting evidence reveals a heterologous interaction of the NOP receptor with other G protein-coupled receptors, including MOR, DOR, and KOR, which may subsequently influence their function. Our focus in this review is to summarize and discuss the findings that delineate the cellular mechanisms of NOP receptor signaling and regulation and the regulation of other receptors by N/OFQ and the NOP receptor.

Authors+Show Affiliations

Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

23395957

Citation

Donica, Courtney L., et al. "Cellular Mechanisms of Nociceptin/orphanin FQ (N/OFQ) Peptide (NOP) Receptor Regulation and Heterologous Regulation By N/OFQ." Molecular Pharmacology, vol. 83, no. 5, 2013, pp. 907-18.
Donica CL, Awwad HO, Thakker DR, et al. Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ. Mol Pharmacol. 2013;83(5):907-18.
Donica, C. L., Awwad, H. O., Thakker, D. R., & Standifer, K. M. (2013). Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ. Molecular Pharmacology, 83(5), 907-18. https://doi.org/10.1124/mol.112.084632
Donica CL, et al. Cellular Mechanisms of Nociceptin/orphanin FQ (N/OFQ) Peptide (NOP) Receptor Regulation and Heterologous Regulation By N/OFQ. Mol Pharmacol. 2013;83(5):907-18. PubMed PMID: 23395957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ. AU - Donica,Courtney L, AU - Awwad,Hibah O, AU - Thakker,Deepak R, AU - Standifer,Kelly M, Y1 - 2013/02/08/ PY - 2013/2/12/entrez PY - 2013/2/12/pubmed PY - 2013/9/12/medline SP - 907 EP - 18 JF - Molecular pharmacology JO - Mol. Pharmacol. VL - 83 IS - 5 N2 - The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is the fourth and most recently discovered member of the opioid receptor superfamily that also includes μ, δ, and κ opioid receptor subtypes (MOR, DOR, and KOR, respectively). The widespread anatomic distribution of the NOP receptor enables the modulation of several physiologic processes by its endogenous agonist, N/OFQ. Accordingly, the NOP receptor has gained a lot of attention as a potential target for the development of ligands with therapeutic use in several pathophysiological states. NOP receptor activation frequently results in effects opposing classic opioid receptor action; therefore, regulation of the NOP receptor and conditions affecting its modulatory tone are important to understand. Mounting evidence reveals a heterologous interaction of the NOP receptor with other G protein-coupled receptors, including MOR, DOR, and KOR, which may subsequently influence their function. Our focus in this review is to summarize and discuss the findings that delineate the cellular mechanisms of NOP receptor signaling and regulation and the regulation of other receptors by N/OFQ and the NOP receptor. SN - 1521-0111 UR - https://www.unboundmedicine.com/medline/citation/23395957/Cellular_mechanisms_of_nociceptin/orphanin_FQ__N/OFQ__peptide__NOP__receptor_regulation_and_heterologous_regulation_by_N/OFQ_ L2 - http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=23395957 DB - PRIME DP - Unbound Medicine ER -